ABSTRACT
Variation in pathogenetic pattern was suggested on the basis of an evaluation of biological and tumor-related factors carried out in 505 patients with primary cervical tumors, stage I-III. Clinical course and prognosis appeared to be in correlation with the variation.
Subject(s)
Uterine Cervical Neoplasms/pathology , Adult , Age Factors , Aged , Female , Humans , Middle Aged , Neoplasm Staging , PrognosisABSTRACT
Comparison was made of changes in such morphological characteristics of tumor as cell differentiation and mitotic activity in 142 patients with endometrial carcinoma in the course of treatment, using tamoxifen or oxyprogesterone capronate or both, and those of estrogen background (karyopicnotic, eosinophilic and maturity indices, numerical index of maturity and blood-estradiol level). Three levels of estrogen background-low, medium and high-were identified by assay of the colpocytological indices in postmenopausal patients with endometrial carcinoma. Levels of the colpocytological indices observed at high indices of estrogen background proved a reliable numerical criterion for evaluating the sensitivity of the patients to neoadjuvant hormone therapy. A significant correlation was established between high estrogen background, pathogenetic variant I and high differentiation of tumor cells. The high incidence of hormonal pathology in tumor tissue was registered when the colpocytological indices dropped by half after oxyprogesterone capronate treatment, and by third-after combined therapy (tamoxifen + oxyprogesterone capronate). In cases free from pronounced pathomorphism, said indices dropped by not more than 20%.
Subject(s)
Antineoplastic Agents, Hormonal/therapeutic use , Endometrial Neoplasms/chemistry , Endometrial Neoplasms/drug therapy , Estrogens/metabolism , 17 alpha-Hydroxyprogesterone Caproate , Aged , Chemotherapy, Adjuvant , Endometrial Neoplasms/pathology , Estrogen Antagonists/administration & dosage , Female , Gene Expression Regulation, Neoplastic , Humans , Hydroxyprogesterones/administration & dosage , Middle Aged , Postmenopause , Prognosis , Tamoxifen/administration & dosageABSTRACT
The study involved 1,256 cases of endometrial carcinoma. Minimal tumor (up to 2 cm in diameter, invasion- up to 0.5 cm) was diagnosed in 30%. This pattern showed a low potential for progression and metastasis spreading. Feasibility of identification of minimal cancer of the endometrium in the course of screening for hormone-dependent tumors of the reproductive system is discussed.
