[Comparative evaluation of cardiotropic effects of nicamag, panangin and asparkam]. / Sravnitel'naia otsenka kardiotropnogo vliianiia nikamara, panangina i asparkama.

Experiments on 75 dogs with experimental myocardial infarction were made to study and compare the therapeutic effect of nicamag (a mixture of potassium and magnesium nicotinates) in a dose of 10 mg/kg, panangin and asparkam (potassium and magnesium aspartates). Nicamag rapidly precipitated postinfarction arrhythmia and made the ECG completely return to normal in the majority of cases. A beneficial effect of the drug on carbohydrate, energy and electrolyte metabolism in the myocardium was discovered to underlie the above-described action. Nicamag abruptly lowered the titers of cardial antibodies, increased the fibrinalytic activity of the blood which is accounted for by the effect of the anion--nicotinic acid.

[Interhemispheric pharmacological asymmetry]. / O mezhpolusharnoi farmakologicheskoi asimmetrii.

Based on primary change of the biochemistry of left hemisphere cortical neurons induced by aminazine and sodium bromide the conclusion is made about the presence of interhemispheric pharmacological asymmetry (IPA). The known data on the primary effect of alcohol on the right hemisphere are confirmed by the presence of the IPA.

[Effect of the neuropeptide tuftsin and its derivatives on metabolism in various structures of the brain]. / Vliianie neiropeptida taftsina i ego proizvodnykh na obmen veshchestv v razlichnykh strukturakh golovnogo mozga.

A study was made of the effect of the neuropeptide tuftsin and its derivatives on some indicators of the metabolism in limbic structures and cortex of the brain in 200 rats. It was shown that tuftsin and its derivatives raise the content of nicotinamide coenzymes at the expense of the oxidized forms of NAD, activate cytochrome-c-oxidase and dehydrogenases largely in the limbic structures. Thus the peptides under study were found to increase the intensity of cell respiration and to enhance intracellular redox processes, i. e. to largely activate the vital activity of the cells of the brain emotiogenous structures.

[Electroencephalogram changes in animals with neurosis as a correlate of metabolic brain disorders]. / Izmeneniia élektroéntsefalogrammy zhivotnykh pri nevroze kak korrelat metabolicheskikh narushenii mozga.

Experiments were made to correlate changes in bioelectrical activity of the brain of different animals (rats, cats, monkeys) with neurosis and its treatment to the time course of the activity of ATPase, one of the most important enzymes of energy metabolism. It was demonstrated that the electroencephalogram (EEG) taken during neurosis is marked by an increase in the total energy of quick-wave components and reduction in the total energy of slow-wave ones in all the structures under study, by the deterioration of the rhythm change response. These changes corresponded with the inhibited activity of brain Na, K-ATPase, particularly of Mg-ATPase. The EEG returned to normal and ATPases were activated after nikogamol injections.

[Biochemical disturbances in the chronic use of alcohol and ways to correct them]. / Biokhimicheskie narusheniia pri khronicheskom potreblenii alkogolia i puti ikh korrektsii.

It is established in experiments on rats that variations in the activity of alcohol dehydrogenase, catalase, content of nicotinamide enzymes and lipid peroxides may be used as tests to study formation of liking for spirits. Pathways of lithium nicotinate normalizing effect on metabolic disturbances in tissues and the substance possible use as an anti-alcoholic agent are discussed.

[Effectiveness of lithium nicotinate in the treatment of experimental alcoholism]. / Effektivnost' nikotinata litiia v terapii éksperimental'nogo alkogolizma.

The data on the efficacy of lithium nicotinate in therapy of experimental alcoholism are provided. The drug is capable of retarding the formation of alcoholic motivation. During treatment of psychic or physical alcoholic dependence, an antidepressant effect of the drug could be also seen. Under experimental acute alcoholic poisoning the drug attenuates the symptoms of intoxication. Antialcoholic effect of lithium nicotinate correlates with the normalization of the background EEG readings, activity of alcohol dehydrogenase, catalase, with the elevated content of the oxidized forms of NAD, NADP and the decreased level of malonic dialdehyde. The possibility of using lithium nicotinate as an antialcoholic drug is discussed.

[Effect of tranquilizers on animal resistance to adequate stimulus exposure of the vestibular apparatus]. / Vliianie trankvilizatorov na ustoichivost' zhivotnykh k vodeistviiu adekvatnykh razdrazhitelei vestibuliarnogo apparata.

The effect of tranquilizers on the intensity of vestibulospinal reflexes and motor activity was studied in 900 centrifuged albino mice. Chemically heterogenous tranquilizers (meprobamate, elenium, nicolit) were applied in therapeutic doses. Actometric studies have shown that the tranquilizers possess group capacity for increasing animal resistance to the action of adequate stimuli to the vestibular apparatus. Meprobamate has exhibited the most pronounced protective effect.

[Mechanism of the anti-arrhythmia action of potassium and magnesium nicotinates]. / K mekhanizmu antiaritmicheskogo distviia nikotinatov kaliia i magniia.

It has been shown in rat experimental aconitinic arrhythmia and in dog postinfarction arrhythmia that combined potassium and magnesium nicotinates show a pronounced anti-arrhythmic effect. The studies on the drug distribution in the tissues indicate that the content of potassium, magnesium and total coenzymatic forms of nicotinic acid rises in the myocardium by the 12th hour from the commencement of the drug administration. Intracellular and exocellular content of potassium and sodium has been shown to return to normal.