ABSTRACT
In experimental myocardial infarction in dogs caused by 60-minute occlusion of the coronary artery with the subsequent 24-hour reperfusion, the administration of quercetin solution (50 mg/kg) was found to improve the contractile function of the left ventricular myocardium, to decrease the incidence of heart rate and conductivity disorders, to contribute to limitation of the ischemic damage area, to exert the protective effect on the ultrastructure of the coronary arteries that can promote the preservation of the vessels' integrity, the improvement of the coronary circulation and the prevention of intravascular thrombus formation.
Subject(s)
Coronary Disease/drug therapy , Heart/drug effects , Myocardial Reperfusion Injury/prevention & control , Quercetin/therapeutic use , Animals , Blood Pressure/drug effects , Blood Pressure/physiology , Cardiac Catheterization , Coronary Disease/physiopathology , Dogs , Drug Evaluation, Preclinical , Female , Heart/physiopathology , Male , Microscopy, Electron , Myocardial Infarction/drug therapy , Myocardial Infarction/physiopathology , Myocardial Reperfusion Injury/physiopathology , Myocardium/ultrastructure , Time FactorsABSTRACT
The possibility to use 0.1% quercetin solution for the treatment of inflammatory diseases of the parotid glands was studied. The effectiveness of treatment of 26 patients was estimated according to the data of clinical examination and cytologic study of the saliva. The results obtained evidence in favour of a high effectiveness of the preparation suggested.
Subject(s)
Parotitis/therapy , Quercetin/administration & dosage , Adult , Aged , Female , Humans , Male , Middle Aged , SolutionsABSTRACT
Wound-healing effect of quercetin granules was examined in 20 experimental animals and in 90 patients with suppurative-inflammatory diseases of the maxillofacial and cervical soft tissue. The results evidence anti-inflammatory and wound-healing effects of quercetin granules used as 20% gel.
