ABSTRACT
Sodium nucleinate increased essentially the insusceptibility of mice to pathogenic escherichia, strain O26, Pr. vulgaris, Ps. aeruginosa, Ser. marcescens, and produced a total stimulating effect on the nonspecific bacterial resistance; analogous stimulating activity was found in the homologous low polymeric RNA from the liver. Sodium nucleinate intensified the insusceptibility of the animals to the tick-born encephalitis and encephalomyelitis viruses, and increased the antibody-forming cells count. The side-effect of heat-inactivated vaccine from pathogenic escherichia was reduced in animals inoculated with sodium nucleinate preliminarily.
Subject(s)
Antibodies, Bacterial/biosynthesis , Antibodies, Viral/biosynthesis , Immunity, Innate/drug effects , RNA/immunology , Animals , Antibody-Producing Cells/immunology , Dose-Response Relationship, Immunologic , Encephalitis Virus, Western Equine/pathogenicity , Encephalitis Viruses, Tick-Borne/pathogenicity , Escherichia coli/pathogenicity , Immunization , Mice , Mice, Inbred CBA , Nucleic Acids/immunology , Proteus vulgaris/pathogenicity , Pseudomonas aeruginosa/pathogenicity , Serratia marcescens/pathogenicity , Time FactorsABSTRACT
The investigation of antiviral antibody titers to 8 different antigens: measles, influenza A2 and B, parainfluenza types 1, 2, 3, adenovirus and smallpox, of interferon in the blood serum, the interferon-synthesizing activity of the peripheral blood leukocytes in patients with autoimmune diseases in the period of the disease exacerbation revealed a number of immunological features. Thus, in all groups of patients antibody titers were high to measles, influenza, parainfluenza type 3 viruses, and titers of leukocyte interferon and interferon in the blood serum were 3-4-fold lower than in the control group.
