ABSTRACT
We described experience on implementation of HIV counseling and testing in routine practice of 36 family clinics in 4 regions. Overall from July 2012--till February 2014 (included), the services of counseling and testing were provided to 2 535 clients; 15 of them were found to be HIV-positive. According to data obtained, 40% who tested positive were provided with further services (registered at the AIDS centers, received CD4, prescribed ART). While implementing counseling and testing in GPs practice we found that there are some problems with most at risk groups identification; reporting documents are complicated and need much time to be filled, so there are many mistakes were found; also, there is no clear and effective mechanism of getting accurate and validate information by GPs about patients who were found to be HIV-positive from AIDs Centers, as for now family doctors get this information mainly from their patients.
Subject(s)
Counseling/statistics & numerical data , Family Practice/methods , General Practice/methods , HIV Infections/prevention & control , Practice Patterns, Physicians'/statistics & numerical data , HIV Infections/diagnosis , HIV Infections/epidemiology , HIV Seropositivity/diagnosis , HIV Seropositivity/epidemiology , Humans , UkraineABSTRACT
Copolymers of N-polyvinylpyrrolidone-acrylic acid (AB-1) and adamantane derivatives are known to possess marked antiviral activity in in vitro and in ovo models. Among the constructed preparations of AB-1 modified by adamantane derivatives some, especially AB-4 (modified by deitiforin), were found to show more extended antiviral activity and to inhibit markedly virus reproduction in susceptible permissive cell cultures and chicken embryos. In AB-4 treated cells and allantoic sacs, virus titers (influenza virus, herpes virus, and HIV) and virus antigen concentration were decreased. On the other hand, herpes virus-specific thymidine kinase and of DNA-polymerases isolated from Escherichia coli, Plectonema boryanum, and herpes virus type 1 infected murine brain tissue retained their activity after incubation with AB-4 or AB-2. The compounds investigated, in view of their effect on virus reproduction, are thought to be prospective as antiviral agents.
