ABSTRACT
AIM: To investigate overexpression of c-erbB2, expression of the p53 protein product and proliferation rates in benign breast lesions with specific reference to apocrine adenosis. METHODS: Twenty one cases of apocrine adenosis were stained with monoclonal antibodies to p185, the protein product of the c-erbB2 oncogene, the protein product of the p53 tumour suppressor gene and to the cell cycle related protein Ki67. Three cases were associated with concomitant ductal carcinoma in situ of large cell type and two were associated with invasive tubular or cribriform carcinoma. RESULTS: Twelve (57.1%) cases showed membrane staining for c-erbB2 oncoprotein of apocrine cells within sclerosing adenosis and six (28.6%) had occasional p53 protein positive cells. One case not associated with carcinoma showed extensive staining of apocrine metaplasia outside the area of apocrine adenosis. The proliferation rate, as measured by Ki67 staining, was increased in some of the lesions and all lesions showed at least some of the cells to be in the cell cycle. CONCLUSIONS: The expression of abnormal oncogene products and increased proliferation in some of these apocrine lesions questions the supposed degenerative nature of the atypia seen in such cases and suggests that there may be an association between these lesions and large cell ductal carcinoma in situ and hence invasive carcinoma.
Subject(s)
Biomarkers, Tumor/analysis , Fibrocystic Breast Disease/chemistry , Neoplasm Proteins/analysis , Nuclear Proteins/analysis , Receptor, ErbB-2/analysis , Tumor Suppressor Protein p53/analysis , Adult , Aged , Aged, 80 and over , Breast Neoplasms/pathology , Carcinoma, Ductal, Breast/genetics , Carcinoma, Ductal, Breast/pathology , Female , Fibrocystic Breast Disease/genetics , Fibrocystic Breast Disease/metabolism , Fibrocystic Breast Disease/pathology , Gene Expression Regulation, Neoplastic , Genes, erbB-2 , Humans , Ki-67 Antigen , Middle Aged , MitosisABSTRACT
Bazex syndrome is a rare cutaneous paraneoplastic phenomenon not previously reported in association with neuroendocrine tumours. We describe a patient who responded well to treatment with octreotide.
Subject(s)
Acrodermatitis/complications , Carcinoma, Neuroendocrine/complications , Liver Neoplasms/complications , Pancreatic Neoplasms/complications , Paraneoplastic Syndromes/complications , Acrodermatitis/drug therapy , Aged , Carcinoma, Neuroendocrine/secondary , Humans , Liver Neoplasms/secondary , Male , Octreotide/therapeutic use , Pancreatic Neoplasms/secondary , Paraneoplastic Syndromes/drug therapySubject(s)
Hemangioendothelioma/complications , Spinal Cord Compression/etiology , Adolescent , Humans , MaleSubject(s)
Adenocarcinoma/pathology , Apocrine Glands/pathology , Breast Neoplasms/pathology , Cicatrix/complications , Fibrocystic Breast Disease/pathology , Biopsy, Needle , Cytodiagnosis , Diagnostic Errors , Female , Fibrocystic Breast Disease/complications , Fibrocystic Breast Disease/metabolism , Humans , Immunoenzyme Techniques , Middle Aged , Predictive Value of TestsABSTRACT
A case of papillary tubular adenoma of the skin in a 31-year-old black man is reported. This lesion is also termed papillary eccrine adenoma, and it commonly occurs in the extremities.
