Cerebrovascular Perfusion among Older Adults with and Without Cardiovascular Disease.

BACKGROUND AND PURPOSE: Cardiovascular disease (CVD) encompasses a range of disorders that affect health and functioning in older adults. While cognitive declines have been linked to both cardiovascular and cerebral blood perfusion, protective neurovascular mechanisms raise the question whether cerebrovascular perfusion differs as a function of cardiovascular health status. The present study examined whether cerebrovascular perfusion significantly differs between healthy older adults with and without diagnosed CVD. The study also examined whether previously documented sex differences in cerebral perfusion would be replicated. METHODS: Twenty CVD patients without significant heart failure and 39 healthy controls were recruited to undergo a comprehensive assessment, including an interview, echocardiogram, and magnetic resonance imaging). Arterial spin labeling was used to quantify cerebral blood perfusion. RESULTS: Both groups exhibited mean left ventricular ejection fractions that fell within normal limits. In line with previous research, women exhibited significantly higher cerebral perfusion than men. There were no significant group differences in whole brain cerebrovascular perfusion, regional perfusion, or white matter perfusion by patient status after accounting for sex and age. CONCLUSIONS: These findings suggest that the effects of mild CVD on cerebrovascular perfusion are minimal. Future studies are needed to investigate the mechanisms involved in maintaining cerebrovascular perfusion in the context of altered peripheral perfusion and to determine whether this finding extends to more acute or severe CVD.

C3Logix assessment of neuropsychological performance in athletes and nonathletes.

Physical activity (PA) has been shown to enhance physical health, mental health, and cognitive functioning. Adult and older adult research shows that PA positively influences neuropsychological performance and protects against cognitive decline. This study investigated neuropsychological performance in uninjured athletes and nonathletes using an iPad-based neuropsychological battery called C3Logix. Since literature suggests that PA enhances cognitive functioning, athletes may perform better on neurocognitive measures than nonathletes due to athletes' assumed higher level of PA. We hypothesized that collegiate athletes would outperform nonathletes on all cognitive tasks. Ninety-five athletes and 92 nonathletes completed the neurocognitive assessments and results showed that athletes outperformed nonathletes on reaction time tasks, but not in other cognitive domains. The implications of this study included extending the work of previous research using C3Logix and added to our understanding of a possible difference in reaction time between healthy collegiate athletes and nonathletes.