[Comparison of efficacy of combined use of liquid cytology and immunohistochemical assay of p16ink4 and standard procedure and high risk evaluation by polymerase chain reaction of human papillomavirus infection in diagnosing cervical dysplasia and carcinoma].

Efficacy of liquid cytology, on the one hand, and those of standard one, appraisal of high risk of cancer by polymerase chain reaction (PCR) of human papillomavirus infection and immunohistochemical assay of p16ink4 high risk in cervical carcinoma diagnosis, on the other, was evaluated PCR of high risk of cancer (dysplasia-free) was detected in 73% (n = 73), CIN I-II--78%, CIN II-III--89%, CIN III and carcinoma--100%. p16ink4 was not detected in dysplasia-free cases and it was--(16%) in CIN I-II, (89%) CIN II-III, (90%) CIN III and (100%)--in carcinoma. Hence, unlike p16ink4 expression (p < or = 0.001), a correlation between the increase in the number of those infected with papillomavirus was not significantly higher than that of dysplasia grade (p < or = 0.05). It is suggested that combined use of liquid cytology and immunohistochemical assay of p16ink4 is more effective.

[The role of melatonin in regulation of gonadal function and its use in the treatment of pathological climax symptoms].

Pathological current of climacterium leads to significant decrease in quality of life of women. Hormone therapy has a number of contra-indications. With the purpose of optimization of treatment of patients with a climacteric syndrome search of new and more perfect approaches to therapy of climacteric frustration is necessary. Melatonin production in a human body decreases with the years and its production in old age makes only half from its level. Age decrease of melatonin synthesis leads to progressive decrease of woman fertility. In this connection the research of a level of melatonin in women with a climacteric syndrome depending on current of disease was carried out. The opportunity to use the Melaxen in treatment of symptoms of pathological climacterium both in the form of monotherapy, and in combination with replacement hormone therapy was estimated. The greatest efficiency of application of Melaxen in combination with hormone replacement therapy has been established.

[Analysis of the sequelae of induced abortion (based on the clinical data of the V.I. Lenin Kazan Institute for the Training of Physicians)]. / Analiz posledstvii iskusstvennogo aborta (po materialam klinik Kazanskogo instituta usovershenstovovaniia vrachei im. V.I. Lenina).

PIP: Of 4087 women (aged 16 to 44 years old; 218 primigravida) subjected to induced abortion during the last 3 years, 762 (18.6%) developed complications. The complications were divided into three groups: group 1 included 64 women who developed complication within the first 7 days after abortion, group 2 included 46 women who developed complications within 7-30 days after abortion, and group 3 included 652 women with late complications. Of 64 women in group 1, 7 had perforation of the uterus, 28 had hematometra, and 29 has incomplete abortion. All 46 women in group 2 has endometritis. Of 652 women in group 3, 4 has placental polyps, 232 has inflammation with associated secondary infertility (hysterosalpingography indicated tubal obstruction in 194 and peritubal adhesions in 38), and 416 had disorders of the menstrual function. In addition to general clinical examination, 50 women with inflammation and tubal infertility underwent immunological examination and allergy testing. Of 50 patients, 35 were found to have skin rush, hives, drug or food hypersensitivity. The patients with allergy manifestations had marked inhibition of cellular immunity seen as decrease in T-lymphocyte count and 2 items increase in null lymphocyte count (B-lymphocyte count did not differ from that in healthy controls). The patients with tubal infertility received combined treatment. Conservative treatment including hydrotherapy, anti-inflammatory agents and electric stimulation was effective 123 of 232 women.^ieng