ABSTRACT
The roles of 131Cs and 67Ga in the evaluation of solitary thyroid nodules were investigated. Radionuclide scans were performed with 67Ga and 131I in 27 patients and with 131Cs and 131I in 43 patients. Gallium-67 detected only two of eight malignant nonfunctioning nodules and 131Cs detected one of three such nodules. The contribution of 131Cs and 67Ga to the preoperative identification of malignant thyroid lesions is of doubtful value.
Subject(s)
Cesium Radioisotopes , Radionuclide Imaging , Thyroid Neoplasms/diagnosis , Adenocarcinoma/diagnosis , Adenoma/diagnosis , Humans , Iodine RadioisotopesABSTRACT
In 68 euthyroid patients undergoing 131I thyroid function tests the thyroidal, urinary and plasma protein-bound radioactivity has been serially measured for 14 days. The patients were subdivided in controls and 9 groups treated with potassium iodide, carbimazole, potassium perchlorate and TSH, singly or in combination. The aim was to devise a treatment scheme for accelerating the release of iodine from the thyroid and the elimination from the body in cases of accidental radioiodine poisoning if the patient is seen after the radioiodine has already been taken up by the gland. All treatment schedules were effective, but TSH injections gave the best results, especially if combined with carbimazole and potassium perchlorate. This combination is the treatment of choice under these circumstances.
Subject(s)
Carbimazole/therapeutic use , Decontamination , Iodine Radioisotopes , Potassium Iodide/therapeutic use , Thyroid Gland/metabolism , Thyrotropin/therapeutic use , Blood Proteins/metabolism , Body Burden , Half-Life , Humans , Iodine/blood , Iodine/metabolism , Iodine Radioisotopes/urine , Protein Binding , Thyroid Gland/drug effectsSubject(s)
Bacteriuria/diagnosis , Water , Administration, Oral , Diuresis , Escherichia coli/isolation & purification , Female , Furosemide/administration & dosage , Glomerular Filtration Rate , Humans , Injections, Intravenous , Klebsiella/isolation & purification , Male , Micrococcus/isolation & purification , Proteus/isolation & purification , Pseudomonas aeruginosa/isolation & purification , Staphylococcus/isolation & purification , Urinary Tract Infections/diagnosis , Urinary Tract Infections/microbiology , Urine/physiology , Water/administration & dosageSubject(s)
Goiter, Endemic/epidemiology , Growth , Nutritional Physiological Phenomena , Adolescent , Adult , Age Determination by Skeleton , Body Height , Body Weight , Child , Female , Goiter, Endemic/blood , Greece , Hand/diagnostic imaging , Health Surveys , Humans , Iodine/analysis , Lipids/blood , Male , Nutrition Surveys , Rural Population , Sex Factors , Skinfold Thickness , Water/analysis , Water SupplySubject(s)
Goiter, Endemic/etiology , Iodine , Adaptation, Psychological , Deficiency Diseases/complications , Female , Goiter, Endemic/epidemiology , Greece , Humans , Iodine/metabolism , Iodine Radioisotopes , Metabolic Clearance Rate , Thyroid Function Tests , Thyroid Hormones/metabolism , Triiodothyronine/metabolismSubject(s)
Goiter, Endemic/epidemiology , Adolescent , Age Factors , Calcium Carbonate/analysis , Diseases in Twins , Escherichia coli/isolation & purification , Female , Goiter, Endemic/genetics , Greece , Humans , Iodine/analysis , Magnesium/analysis , Male , Sex Factors , Soil/analysis , Water Pollution , Water SupplySubject(s)
Goiter, Endemic/blood , Thyrotropin/blood , Thyroxine/blood , Triiodothyronine/blood , Adolescent , Adult , Binding, Competitive , Boston , Female , Greece , Humans , Middle Aged , RadioimmunoassaySubject(s)
Thyroid Function Tests , Adolescent , Adult , Aged , Child , Humans , Hyperthyroidism/diagnosis , Hypothyroidism/diagnosis , Iodine Radioisotopes , Middle Aged , Thyroxine/bloodABSTRACT
Calcium absorption, as measured by whole-body retention of isotopic (47)calcium, was investigated in 10 controls and 10 patients with primary biliary cirrhosis before and after medium-chain triglyceride therapy. Absorption of calcium was impaired in eight patients with primary biliary cirrhosis, three of whom had normal serum bilirubin. Mean absorption was significantly less in patients with primary biliary cirrhosis than in controls. Impaired calcium absorption correlated well with increased faecal fat excretion and less well with the intensity of jaundice. Osteoporosis was diagnosed radiologically in seven patients with primary biliary cirrhosis, and calcium absorption was restored to normal in seven out of eight patients after medium-chain triglyceride therapy. Decrease of steatorrhoea, weight gain, and relief of bone pain have been noted in most patients with primary biliary cirrhosis after therapy. It is concluded that bone disease occurs early in primary biliary cirrhosis, and early medium-chain triglyceride therapy in these patients is suggested.