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1.
J Acoust Soc Am ; 142(4): 2332, 2017 10.
Article in English | MEDLINE | ID: mdl-29092578

ABSTRACT

The lattice Boltzmann method (LBM) is emerging as a powerful engineering tool for aeroacoustic computations. However, the LBM has been shown to present accuracy and stability issues in the medium-low Mach number range, which is of interest for aeroacoustic applications. Several solutions have been proposed but are often too computationally expensive, do not retain the simplicity and the advantages typical of the LBM, or are not described well enough to be usable by the community due to proprietary software policies. An original regularized collision operator is proposed, based on the expansion of Hermite polynomials, that greatly improves the accuracy and stability of the LBM without significantly altering its algorithm. The regularized LBM can be easily coupled with both non-reflective boundary conditions and a multi-level grid strategy, essential ingredients for aeroacoustic simulations. Excellent agreement was found between this approach and both experimental and numerical data on two different benchmarks: the laminar, unsteady flow past a 2D cylinder and the 3D turbulent jet. Finally, most of the aeroacoustic computations with LBM have been done with commercial software, while here the entire theoretical framework is implemented using an open source library (palabos).

2.
J Theor Biol ; 394: 68-76, 2016 Apr 07.
Article in English | MEDLINE | ID: mdl-26802480

ABSTRACT

We propose a new numerical model to describe thrombus formation in cerebral aneurysms. This model combines CFD simulations with a set of bio-mechanical processes identified as being the most important to describe the phenomena at a large space and time scales. The hypotheses of the model are based on in vitro experiments and clinical observations. We document that we can reproduce very well the shape and volume of patient specific thrombus segmented in giant aneurysms.


Subject(s)
Intracranial Aneurysm/complications , Intracranial Aneurysm/pathology , Models, Biological , Spatio-Temporal Analysis , Thrombosis/complications , Thrombosis/pathology , Computer Simulation , Hemorheology , Human Umbilical Vein Endothelial Cells/metabolism , Humans , Intracranial Aneurysm/physiopathology , RNA, Messenger/genetics , RNA, Messenger/metabolism , Stress, Mechanical , Thrombosis/physiopathology
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