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1.
Sci Rep ; 10(1): 3, 2020 01 08.
Article in English | MEDLINE | ID: mdl-31913294

ABSTRACT

Early fusion of the sagittal suture is a clinical condition called, sagittal craniosynostosis. Calvarial reconstruction is the most common treatment option for this condition with a range of techniques being developed by different groups. Computer simulations have a huge potential to predict the calvarial growth and optimise the management of this condition. However, these models need to be validated. The aim of this study was to develop a validated patient-specific finite element model of a sagittal craniosynostosis. Here, the finite element method was used to predict the calvarial morphology of a patient based on its preoperative morphology and the planned surgical techniques. A series of sensitivity tests and hypothetical models were carried out and developed to understand the effect of various input parameters on the result. Sensitivity tests highlighted that the models are sensitive to the choice of input parameter. The hypothetical models highlighted the potential of the approach in testing different reconstruction techniques. The patient-specific model highlighted that a comparable pattern of calvarial morphology to the follow up CT data could be obtained. This study forms the foundation for further studies to use the approach described here to optimise the management of sagittal craniosynostosis.


Subject(s)
Cranial Sutures/growth & development , Craniosynostoses/pathology , Skull/cytology , Child, Preschool , Computer Simulation , Craniosynostoses/diagnostic imaging , Craniosynostoses/surgery , Craniotomy , Finite Element Analysis , Humans , Image Processing, Computer-Assisted , Infant , Infant, Newborn , Longitudinal Studies , Retrospective Studies , Skull/diagnostic imaging , Tomography, X-Ray Computed/methods
2.
Mol Syndromol ; 10(1-2): 74-82, 2019 Feb.
Article in English | MEDLINE | ID: mdl-30976281

ABSTRACT

Craniosynostosis is a medical condition caused by the early fusion of the cranial joint. The finite element method (FEM) is a computational technique that can answer a variety of "what if" questions in relation to the biomechanics of this condition. The aim of this study was to review the current literature that has used FEM to investigate the biomechanics of any aspect of craniosynostosis, being its development or its reconstruction. This review highlights that a relatively small number of studies (n = 10) has used FEM to investigate the biomechanics of craniosynostosis. Current studies set a good foundation for the future to take advantage of this method and optimize reconstruction of various forms of craniosynostosis.

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