ABSTRACT
BACKGROUND/PURPOSE: When evaluating skin care products for human skin, quantitative test methods need to be simple, precise and reliable. Optical coherence tomography (OCT), provides high-resolution sectional images of translucent materials to a depth of a few millimeters, a technique usually applied to medical measurements in ophthalmology and dermatology. This study aimed to demonstrate the application of OCT as the main technique for monitoring changes in skin topography during tests of a wrinkle-reduction product in humans. METHODS: We used a commercial OCT apparatus to perform clinical examinations of skin roughness in treated and non-treated sites in the periorbital region of thirty human voluntaries who were using an anti-aging product commercially available: Natura Chronos® Flavonóides de Passiflora 45+ FPS15, from Natura Cosméticos, Brazil. Measurements were performed days 0, 7, 14 and 28 of treatment. Equipment and software allowed real-time recording of skin roughness parameters and wrinkle depths. RESULTS: The OCT measurements have allowed the monitoring of changes in skin roughness, which have shown reduction in treated sites around 10%. The obtained depth distributions also indicate reduction in the occurrence of wrinkles deeper than 170 µm. The verified results are consistent with those typically obtained after successful treatment with modern anti-aging products. CONCLUSION: By using the OCT technique, it was possible to quantify changes in skin roughness and in the distribution of depths of skin wrinkles, with adequate sensitivity. OCT imaging allows the direct visualization of the skin topography with resolution of micrometers, a reliable and interactive tool for clinical use. Therefore, for the first time, we demonstrated the use of OCT technique to verify the efficacy of cosmetic products in real time.
Subject(s)
Skin Aging/drug effects , Skin Aging/physiology , Skin Cream/administration & dosage , Skin/cytology , Skin/drug effects , Tomography, Optical Coherence/methods , Administration, Topical , Adult , Drug Monitoring/methods , Female , Humans , Middle Aged , Reproducibility of Results , Sensitivity and SpecificityABSTRACT
An Ar-ion laser was used to pump a Nd:YLF laser, in both σ and π polarizations, in a longitudinal scheme. In spite of the small absorption coefficient at the pump (~0.25 cm (-1)), a careful laser design can circumvent this problem, and efficiencies as high as those attained with semiconductor pumping schemes are reported. The laser fundamental parameters were experimentally determined. A double-pass net gain as high as 10(3) was measured, and an output power of 1 W was obtained with a pumping power of 6 W.
ABSTRACT
Measurements of the bifocal, thermally induced lenses of a cw Nd:YAG laser were obtained. We observed four different focal lengths that are polarization and direction dependent. The focal lengths were used to design stable resonators with large fundamental mode filling in the laser gain medium. The beam is totally polarized in the desired direction even without an intracavity Brewster window. We developed a general approach for the optimization of single-lamp, cw-pumped Nd:YAG lasers. Up to 22 W of cw output power in the vertically polarized TEM(00) mode and 15 W in the horizontal polarization are obtained for moderate lamp currents. Also, we demonstrate mode locking with 56-ps pulse duration at 33 A of lamp current and up to 13 W of average output power.
