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1.
Ocul Immunol Inflamm ; 30(4): 829-838, 2022 May 19.
Article in English | MEDLINE | ID: mdl-33264037

ABSTRACT

PURPOSE: To evaluate the wide-field fundus fluorescein angiography (WFA) characteristics of uveitis associated with juvenile idiopathic arthritis (JIA-uveitis). METHODS: Retrospective review of records. WFA with Spectralis (Heidelberg) of JIA-uveitis patients were analyzed using the scoring system by Angiography Scoring for Uveitis Nomenclature. RESULTS: Thirty-seven eyes of 20 patients were studied. A total score of at least 1 was noted in 27 eyes (72.97%). WFA features included optic disc hyperfluorescence (51.35%), macular leakage (27.03%), retinal vascular staining/leakage at posterior pole (27.03%) and peripheral retina (64.86%), capillary leakage at the posterior pole (37.84%), and peripheral retina (59.46%). A decision to change the management plan was made in 8 of 9 patients with bilateral quiet anterior chambers after WFA results. CONCLUSION: More than 70% of JIA-uveitis eyes showed some WFA-evidence of posterior segment inflammation, which changed the course of therapy for a major proportion of patients with no clinically active anterior chamber inflammation.


Subject(s)
Arthritis, Juvenile , Optic Disk , Uveitis , Arthritis, Juvenile/complications , Arthritis, Juvenile/diagnosis , Fluorescein Angiography/methods , Humans , Inflammation , Retrospective Studies , Uveitis/diagnosis , Uveitis/etiology
2.
Am J Ophthalmol Case Rep ; 21: 101014, 2021 Mar.
Article in English | MEDLINE | ID: mdl-33615036

ABSTRACT

PURPOSE: To find a remedy for serpiginous choroiditis refractory to oral prednisone and chlorambucil treatment. OBSERVATIONS: Eight eyes of four patients (all female) with advanced macular involvement secondary to serpiginous choroiditis were included in the study. The average age of the patients was 45.2 years. One eye of each patient was legally blind and the lesion was close to the fovea in the other eye. All four patients failed oral prednisone and chlorambucil therapy. However, case 1 responded to chlorambucil treatment after intravitreal dexamethasone implant implantation and discontinuation of oral prednisone. Case 2 responded to chlorambucil therapy when oral prednisone was stopped in combination with infliximab therapy. Due to long follow-up period of more than four years, these two cases are considered to be cured. Case 3 and case 4 were not able to achieve remission with chlorambucil and immunomodulatory therapy. They refused intravitreal steroid implant due to side effects profile. CONCLUSIONS AND IMPORTANCE: The stability of WBC counts within toxic levels close to normal or lower limits of normal (3000-4500 cells/µl) during treatment with chlorambucil is an essential factor for the success of this therapy. A combination of dexamethasone intravitreal implant with chlorambucil therapy can be an effective and promising regimen in inducing and maintaining remission in refractory serpiginous choroiditis patients who fail a combination of systemic corticosteroid and chlorambucil therapy.

3.
P R Health Sci J ; 39(1): 34-38, 2020 03.
Article in English | MEDLINE | ID: mdl-32383565

ABSTRACT

OBJECTIVE: To describe the characteristics upon presentation of a cohort of Hispanic patients living in Puerto Rico with ocular mucous membrane pemphigoid (MMP). METHODS: Retrospective chart review of subjects with ocular MMP at one academic institution and one private practice. Patients with clinical evidence of ocular MMP, along with a positive mucous membrane biopsy revealing linear antibody or C3 deposition in the basement membrane zone, or with a positive indirect immunofluorescence assay were included. Descriptive statistical analysis was performed. RESULTS: Eight patients with ocular mucous membrane pemphigoid were identified. The median age upon presentation was 60.5 years; however, 2 patients were in their 4th decade and one in the 5th decade of life. Females constituted 62.5% of the cohort. All patients presented with stage III ocular MMP in at least one eye and 50% had history of trichiasis. Seven out of eight patients (87.5%) had extraocular symptoms for a median duration of 36 months (range 2-144 months). The most common site of extraocular involvement was the oropharynx, present in 87.5% of patients. CONCLUSION: Our results suggest that in Puerto Rico ocular MMP most commonly presents in the seventh decade of life. The presence of symblepharon, trichiasis or oropharyngeal mucosal disease should prompt further evaluation and consideration for immunopathological tissue analysis and an IIF assay.


Subject(s)
Conjunctivitis/diagnosis , Mucous Membrane/pathology , Pemphigoid, Benign Mucous Membrane/diagnosis , Adult , Aged , Biopsy , Cohort Studies , Conjunctivitis/pathology , Female , Fluorescent Antibody Technique, Indirect , Humans , Male , Middle Aged , Pemphigoid, Benign Mucous Membrane/pathology , Puerto Rico , Retrospective Studies
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