ABSTRACT
In this study, a novel resonance light scattering (RLS) sensor was synthesized using polyacrylonitrile nanofibers decorated with magnetic carbon dots (MCDs@NFs) nanocomposite and applied for famotidine (FMD) determination. The MCDs@NFs nanocomposite was synthesized by combining electrospinning and a simple one-step hydrothermal method. Different methods were applied in order to characterize the MCDs@NFs nanocomposite such as: scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), Transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). Light scattering properties of the synthesized nanocomposite in the presence or absence of FMD have been selected as the detection signal considering the fact that FMD addition increases the RLS intensities of the system. Thus, the prepared nanocomposite was employed as a RLS sensor to detect FMD. A linear response was observed under the optimal conditions in range of 0.15-50.0µmolL-1 with detection limit of 0.04µmolL-1. The MCDs@NFs nanocomposite was effectively capable in determining FMD in real samples and the results were close to those results obtained by reversed-phase HPLC method (RP-HPLC).
Subject(s)
Acrylic Resins/chemistry , Biosensing Techniques/methods , Carbon/chemistry , Famotidine/analysis , Nanofibers/chemistry , Famotidine/blood , Famotidine/chemistry , Humans , Magnetics , Nanofibers/ultrastructure , Pharmaceutical Preparations/chemistry , Photoelectron Spectroscopy , Powders , Quantum Dots , Reproducibility of Results , Spectroscopy, Fourier Transform Infrared , Tablets , X-Ray DiffractionABSTRACT
In this paper a sensitive and selective electrochemical sensor for determination of rizatriptan benzoate (RZB) was proposed. A glassy carbon electrode was modified with nanocomposite of multiwalled carbon nanotubes (MWCNTs) and Fe3O4 nanoparticles (Fe3O4/MWCNTs/GCE). The results obtained clearly show that the combination of MWCNTs and Fe3O4 nanoparticles definitely improves the sensitivity of modified electrode to RZB determination. The morphology and electroanalytical performance of the fabricated sensor were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDS), square wave voltammetry (SWV) and cyclic voltammetry (CV). Also, the effect of experimental and instrumental parameters on the sensor response was evaluated. The square wave voltammetric response of the electrode to RZB was linear in the range 0.5-100.0 µmol L(-1) with a detection limit of 0.09 µmol L(-1) under the optimum conditions. The investigated method showed good stability, reproducibility and repeatability. The proposed sensor was successfully applied for real life samples of blood serum and RZB determination in pharmaceutical.
