ABSTRACT
The genotoxic effects of 4 organophosphorus pesticides, i.e., ekatin, fenitrothion, methylparathion and phorate, were assessed employing in vivo chromosomal aberration bioassay in bone marrow cells in rat. Methylparathion and phorate were found to be mutagenic while ekatin was weakly mutagenic. The frequency of chromosomal aberrations induced by fenitrothion did not differ significantly from that observed in negative control.
Subject(s)
Chromosome Aberrations , Insecticides/pharmacology , Organophosphorus Compounds , Animals , Bone Marrow/drug effects , Male , Mutagenicity Tests , Rats , Rats, Inbred StrainsABSTRACT
The genotoxic effects of 4 organophosphorous pesticides, i.e. ekatin, fenitrothion, methylparathion and phorate, were examined employing the micronucleus test in bone marrow cells of the rat. Methylparathion and phorate were found to be mutagenic, while ekatin was weakly mutagenic. The frequency of micronuclei induction by fenitrothion did not differ significantly from that noticed in negative control.
