ABSTRACT
Inguinal hernias present a significant healthcare burden globally, necessitating effective surgical management. This comprehensive review evaluates two primary surgical techniques for managing bilateral inguinal hernias: bilateral open inguinal hernia and Rives-Stoppa repair. This review aims to provide insights into optimal surgical approaches through a comparative analysis of these techniques, including examining advantages, disadvantages, outcomes, and factors influencing technique selection. Bilateral open inguinal hernia repair offers simplicity and familiarity, while Rives-Stoppa repair may provide advantages such as reduced recurrence rates and postoperative complications. The findings underscore the importance of considering patient-specific factors, surgeon expertise, and hospital resources when selecting the optimal approach. Further research is warranted to conduct long-term comparative studies and explore innovations in surgical techniques and materials, ultimately enhancing patient outcomes and advancing inguinal hernia repair practices.
ABSTRACT
Background Breast carcinoma has been the most prevalent cancer in women, with research-based evidence showing a significant rise in the incidence of cancer and related morbidity and mortality in the Indian subcontinent. The predictive value of plasmatic lactate dehydrogenase (LDH) levels has been studied in breast cancer. Numerous studies have connected high LDH values to a poor prognosis, increased risk of incidence, recurrence, and associated mortality in patients with breast carcinoma. This study aimed to assess the clinical profile of breast carcinoma and determine the correlation of serum lactate dehydrogenase levels with the stage of the disease and assessment of high-risk features using histopathology and immunohistochemistry. Methods A total of 75 patients with carcinoma breast were enrolled for this study and classified into two groups: upfront surgery and post-adjuvant therapy. Serum LDH levels were estimated a day before the surgery (baseline) and on postoperative days 1, 7, 14, and 30. The clinical tumor, node, metastasis (cTNM) staging was correlated with pathological tumor, node, metastasis TNM (pTNM) staging and immunohistochemistry findings. Results The clinical characteristics of breast cancer, serum LDH levels, and stage of the disease were collected and analyzed. A significant decreasing trend was noted in LDH values post-op days, and statistically significant higher LDH values were noted in the triple-negative group, positive lymph nodes, and positive lymphovascular invasion patients. Conclusion Regularly elevated levels or an unanticipated rise in serum LDH might indicate poor outcomes. Hence, this non-specific enzyme marker can be suggested to be used routinely to assess disease outcomes.
ABSTRACT
Malignant peripheral nerve sheath is a rare neoplasm seen in humans, with a very small percentage of occurrence in the cervical region. It is an aggressive form of sarcoma, usually arising from peripheral nerves. In this case study, we present a 61-year-old male who was reported to the hospital with a chief complaint of swelling on the right side of his neck. Magnetic resonance imaging (MRI) revealed a heterogeneous mass in the cervical region, which is reported as a schwannoma. The patient was posted for surgery for tumor excision. The patient was managed with analgesics, physical therapy, and wound care. The patient's symptoms were relieved, and he was discharged. In conclusion, combined surgical resection and adjuvant treatments like physical and medical therapy improved the functional outcome. However, this literature does not address radiation therapy.
ABSTRACT
The horseshoe kidney is the most frequent genitourinary fusion abnormality. The horseshoe kidney is a combination of the anatomical abnormalities of ectopia and malrotation. Along with other anomalies, it is linked to malrotations, fluctuating blood flow, high ureter insertion, a tendency to establish a ureteropelvic junction, and blockage in up to one-third of patients, and these are all symptoms of this condition. Kidney calculus and pelvic ureteric junction (PUJ) obstruction are one of horseshoe kidneys' most prevalent side effects and are seen in approximately one-third of the patients. In our case report, we discuss the treatment of a 61-year-old male patient who had been complaining of abdominal pain for the past few years, was found to have a horseshoe kidney, a history of recurrent renal calculi with a non-functioning right side portion, and recurrent urinary tract infections (UTI) treated with open surgery. The patient symptomatically alleviated his symptoms at the three-month follow-up after open surgery; there were no complaints of discomfort or abdominal fullness, and the patient resumed daily routines.
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic will be remembered as one of the defining events of the 21st century. The rapid global outbreak has had significant impacts on human society and is already responsible for millions of deaths. Understanding and tackling the impact of the virus has required a worldwide mobilisation and coordination of scientific research. The COVID-19 Data Portal (https://www.covid19dataportal.org/) was first released as part of the European COVID-19 Data Platform, on April 20th 2020 to facilitate rapid and open data sharing and analysis, to accelerate global SARS-CoV-2 and COVID-19 research. The COVID-19 Data Portal has fortnightly feature releases to continue to add new data types, search options, visualisations and improvements based on user feedback and research. The open datasets and intuitive suite of search, identification and download services, represent a truly FAIR (Findable, Accessible, Interoperable and Reusable) resource that enables researchers to easily identify and quickly obtain the key datasets needed for their COVID-19 research.
