Drug dependence as a split object: Trajectories of neuroscientification and behavioralization at the Max Planck Institute of Psychiatry.

Today, drug dependence is often understood as a "brain disease" and as an indication for behavioral therapy. In this article, I trace the historical development of the notions of drug dependence as a neuronal and behavioral problem in the local research context of the Max Planck Institute of Psychiatry in Munich, Germany. Focusing on the period from the 1950s to the 1980s, I argue that the neuroscientific and behaviorist understanding of "dependence" had two different trajectories that were yoked together under the same institution of self-proclaimed basic research: (a) the neuroscientific notion derived from an older toxicological approach to drug effects that was then accompanied by biochemical methods from the 1950s onwards, and neurochemical approaches from the 1960s and 1970s; and (b) the behaviorist notion had predecessors in psychotherapeutic approaches to addiction that emerged in the 1950s and took a psychodynamic orientation at the Institute. When the Institute positioned itself as a basic research establishment and developed a unified structure during the 1960s, these psychodynamic approaches were excluded for being "too applied." Soon afterward, behaviorist psychotherapeutic approaches to drug dependence emerged in the 1970s, emphasizing their foundation in basic research. Even though neuroscientific and behaviorist notions had some overlaps through the use of animal experimentation and by referring to basic research, researchers using the two approaches remained separate in their respective units during the time period under analysis. When conceptualizing the local scientific occupation with "drug dependence," I apply here the history of science concept of a "split object." Like the "boundary object," the split object is plastic enough to adapt to local conditions and robust enough to maintain its genuine identity. Compared with the boundary object, however, the split object does not invite scientific collaboration. It does, nonetheless, enable epistemic coexistence under a common institutional goal.

Contexts of care for people with differences of sex development: Diversity is still missing in the laboratory routine.

The 2006 Chicago consensus statement of management of disorders/difference of sex development (DSD) has achieved advantages in clinical care and diagnosis for patients and families affect by DSD. This article provides a brief overview of contexts of care for physicians, and points out specific challenges in clinical practice that have arisen from the transformations of the sex/gender system in recent years. We focus on the impact of diagnosis and laboratory measurements. Both laboratory measurements and hormonal therapies still depend on the binary system. One problem is the lack of reference intervals for the different forms of DSD, which means that diversity is often neglected. In the following, we will give a brief insight into this complex topic.

Is sex still binary?

In this perspective article we discuss the limitations of sex as a binary concept and how it is challenged by medical developments and a better understanding of gender diversity. Recent data indicate that sex is not a simple binary classification based solely on genitalia at birth or reproductive capacity but encompasses various biological characteristics such as chromosomes, hormones, and secondary sexual characteristics. The existence of individuals with differences in sex development (DSD) who do not fit typical male or female categories further demonstrates the complexity of sex. We argue that the belief that sex is strictly binary based on gametes is insufficient, as there are multiple levels of sex beyond reproductivity. We also explore the role of sex in sex determination, gene expression, brain development, and behavioural patterns and emphasize the importance of recognizing sex diversity in personalized medicine, as sex can influence disease presentation, drug response, and treatment effectiveness. Finally, we call for an inter- and transdisciplinary approach to study sex diversity and develop new categories and methodologies that go beyond a binary model.

[The Nest as Environment. A Historical Epistemology of the Nesting Instinct in Pregnancy]. / Das Nest als Umwelt. Eine historische Epistemologie des Nestbauinstinkts in der Schwangerschaft.

Today, many pregnancy guides mention a nesting instinct. According to this, pregnant women would be seized by an urge to create the right environment for their child, for example to buy baby equipment or clean the apartment. The concept of the nesting instinct forms a specific configuration of knowledge: While it is widespread in the popular field, it occupies a marginal position in the scientific field. In this paper, I will investigate the historical epistemology of this form of knowledge. In so doing, the following questions are addressed: How did the knowledge about a nesting instinct during pregnancy form? How was the nest as a specific natural-anthropogenic environment constructed? And to what extent do notions of gender and environment interact here? To answer these questions, the study takes the perspective of a history of knowledge in transit, in the longue durée from the nineteenth century to the present. The investigation reveals a gradual feminization of the concept of environment in the knowledge of the nesting instinct. Whereas in the nineteenth century it was often considered a male behavioral pattern and the nest was an analogy to the house, in the first decades of the twentieth century, the instinct transformed into a primarily female characteristic, with the nest representing the interior of the home. A decisive condition for this circulation of knowledge was that the nest became a 'metaphorical thing'. As such, the nest did not simply lead to naturalization, but denoted a natural-social in-between space that increasingly became the goal of female care work.

[From a method for family planning to a differentiating lifestyle drug: images of the pill and its consumer in gynaecological advertising since the 1960s in West Germany and France]. / Vom Mittel der Familienplanung zum differenzierenden Lifestyle-Präparat. Bilder der Pille und ihrer Konsumentin in gynäkologischen Werbeanzeigen seit den 1960er Jahren in der BRD und Frankreich.

Based upon flyers and advertisements for the contraceptive pill from 1961 until 2005, this paper discusses the ways in which the drug and its female users were represented in the marketing of two West European countries, France and the German Federal Republic. As my analysis suggests, national differences are only discernible in the marketing until the end of the 1970s. In West Germany, the pill was depicted from early on as a contraceptive, whereas, due to the restrictive legal situation, in France the pill was marketed as a multi-purpose drug. Nevertheless, the sources in both countries emphasized the safety of the drug. Likewise the representations of women changed from the notion of the married mother to a more diverse image, including young, modern and active women. From the early 1980s on, French and German materials conformed to one another. Now more classification systems were developed, emphasizing the differences between types of pills and types of women. Lifestyle, leisure and fun became increasingly central topics. Correspondingly, the female user was often portrayed in a sexualized way and represented as an active consumer with individual needs and wishes.