ABSTRACT
The different analogues of ebselen-unsubstituted benzisoselenazol-3(2H)-one (2a) 2-pyridylbenzisoselenazol-3(2H)-ones (2b-h) and 7-azabenzisoselenazol-3(2H)-ones (3a-j) were designed as new selenium-containing antiviral and antimicrobial agents and synthesized. Some of them were found in the antiviral assay in vitro to be strong inhibitors of cythopatic activity of herpes simplex virus type 1--HSV-1 (compounds 2a,b,f,h, 3a-j) and encephalomyocarditis virus--EMCV (compounds 2a,h, 3a-f,k,l). The compounds 2a,h and 3a-e,j were found to have an appreciable activity against Gram-positive bacteria (Staphylococcus aureus and Bacillus) in vitro, some of them inhibited growth of pathogenic yeasts (Candida albicans) (3a,b) and filamentous fungi (3a-e,f).
Subject(s)
Anti-Bacterial Agents/chemical synthesis , Antifungal Agents/chemical synthesis , Antiviral Agents/chemical synthesis , Azoles/chemical synthesis , Azoles/pharmacology , Organoselenium Compounds/chemical synthesis , Organoselenium Compounds/pharmacology , Anti-Bacterial Agents/pharmacology , Antifungal Agents/pharmacology , Antiviral Agents/pharmacology , Aza Compounds/chemical synthesis , Aza Compounds/pharmacology , Candida albicans/drug effects , Cell Line , Encephalomyocarditis virus/drug effects , Encephalomyocarditis virus/pathogenicity , Herpesvirus 1, Human/drug effects , Herpesvirus 1, Human/pathogenicity , Humans , Isoindoles , Microbial Sensitivity Tests , Vesicular stomatitis Indiana virus/drug effects , Vesicular stomatitis Indiana virus/pathogenicityABSTRACT
Carnitine deficiency in the serum was found in 5 infants with cystic fibrosis, impaired liver function and neurological symptoms. Clinical improvement and progressive normalization of the carnitine level in the serum, as well of the biochemical parameters of liver function were obtained after enteral pharmacotherapy and a carnitine-rich diet.
