ABSTRACT
The experiments carried out on the model of immobilization stress permit establishing the antiulcer effect of preventive introduction of sodium succinate solution, milk serum solution and solution of milk serum with sodium succinate. A decrease in the degree and number of ulcers and in the integrative indices characterizing the ulcer process after introduction of the studied drugs was accompanied by a fall of the intensity of lipid peroxidation processes.
Subject(s)
Anti-Ulcer Agents/therapeutic use , Stomach Ulcer/prevention & control , Stress, Psychological/complications , Succinates/therapeutic use , Animals , Drug Evaluation, Preclinical , Drug Therapy, Combination , Lipid Peroxidation/drug effects , Rats , Rats, Wistar , Restraint, Physical , Solutions , Stomach Ulcer/etiology , Stomach Ulcer/metabolism , Stress, Psychological/metabolism , Succinic AcidABSTRACT
Ultrastructural changes of myocardium cells, neurons of sensorimotor cerebral cortex, endothelium of blood microvessels were registered by transmissive electron microscopy in mice receiving rock balm preparations per os. Both stimulating and toxic effects were observed dependently on used concentrations. This necessitates dosage to be strictly observed.
Subject(s)
Heart/drug effects , Motor Cortex/drug effects , Myocardium/ultrastructure , Resins, Plant/pharmacology , Animals , Dose-Response Relationship, Drug , Heart Ventricles/drug effects , Heart Ventricles/ultrastructure , Humic Substances , Male , Mice , Microscopy, Electron , Minerals , Motor Cortex/ultrastructure , Resins, Plant/toxicity , Stimulation, ChemicalABSTRACT
The efficacy of a combined use of isoniazid together with polyzid prolonged tuberculostatic and tricarboxylic acid cycle metabolites was experimentally studied in guinea pigs. Mortality rates, pathomorphologic test data and the extent of tuberculous affection in the animals confirm a fairly high efficacy of prolonged polyzid in combination with succinate and malate as pathogenetic drugs.
Subject(s)
Antitubercular Agents/administration & dosage , Isoniazid/administration & dosage , Maleates/administration & dosage , Succinates/administration & dosage , Tuberculosis, Pulmonary/drug therapy , Animals , Delayed-Action Preparations , Drug Evaluation, Preclinical , Drug Therapy, Combination , Guinea Pigs , Male , Organic Chemicals , Succinic AcidSubject(s)
Isoniazid/therapeutic use , Animals , Delayed-Action Preparations , Drug Evaluation, Preclinical , Guinea Pigs , Isoniazid/pharmacokinetics , Isoniazid/toxicity , Lethal Dose 50 , Liver/pathology , Lung/pathology , Male , Tissue Distribution , Tuberculosis/drug therapy , Tuberculosis/mortality , Tuberculosis/pathologySubject(s)
Succinates/therapeutic use , Tuberculosis, Pulmonary/drug therapy , Clinical Trials as Topic , Female , Humans , Male , Succinic AcidSubject(s)
Antitubercular Agents , Tuberculosis/drug therapy , Antitubercular Agents/adverse effects , Drug Therapy, Combination , Ethionamide/adverse effects , Fatty Acids/metabolism , Humans , Isoniazid/adverse effects , Liver/metabolism , Malates/therapeutic use , Metabolic Diseases/chemically induced , Mitochondria/metabolism , Oxidative Phosphorylation , Rifampin/adverse effects , Succinates/therapeutic use , Succinic AcidSubject(s)
Achlorhydria/drug therapy , Gastric Acid/metabolism , Gastric Mucosa/metabolism , Succinates/pharmacology , Adolescent , Adult , Female , Humans , Male , Middle Aged , Succinic AcidABSTRACT
The paper deals with dynamics of tricarboxylic cycle metabolites in the liver after subcutaneous injection of succinate in a dose of 100 mg/kg to guinea pigs. Before the preparation administration the highest level was marked for succinate, malate and citrate. 3 h after the administration the succinate content increased by 57% and 6 h later it returns to the initial level. No essential changes were observed in the content of other tricarboxylic acid cycle metabolites.
Subject(s)
Citric Acid Cycle , Liver/metabolism , Succinates/pharmacology , Animals , Citrates/metabolism , Female , Guinea Pigs , Ketoglutaric Acids/metabolism , Malates/metabolism , Male , Succinates/metabolismSubject(s)
Fatty Acids/blood , Lipids/blood , Tuberculosis, Pulmonary/blood , Acute Disease , Adolescent , Adult , Aged , Female , Humans , Male , Middle AgedABSTRACT
Tubaside causes disturbances in oxidative phosphorylation of the liver mitochondria. Sodium succinate administered during tubaside intoxication favours normalization of the oxygen uptake rate in state 3 and the ADP phosphorylation rate. Sodium succinate weakens the toxic effect of tubaside and favours normalization of p-hydroxylation in the liver. The animals, which were given tubaside in combination with sodium succinate are characterized by a higher survival rate.