Audiovestibular adverse events following COVID-19 vaccinations.

INTRODUCTION: Evidence regarding audiovestibular adverse events post COVID-19 vaccination to date has been inconclusive regarding a potential association. This study aimed to determine if there was an increase in audiovestibular events following COVID-19 vaccination in South-eastern Australia during January 2021-March 2023. METHODS: A multi-data source approach was applied. First, a retrospective observational analysis of spontaneous reports of audiovestibular events to a statewide vaccine safety surveillance service, SAEFVIC. Second, a self-controlled case series analysis using general practice data collected via the POpulation Level Analysis and Reporting (POLAR) tool. RESULTS AND CONCLUSIONS: This study is the first to demonstrate an increase in general practice presentations of vertigo following mRNA vaccines (RI = 1.40, P <.001), and tinnitus following both the Vaxzevria® adenovirus vector and mRNA vaccines (RI = 2.25, P <.001 and 1.53, P <.001 respectively). There was no increase in hearing loss following any COVID-19 vaccinations. Our study, however, was unable to account for the potential of concurrent COVID-19 infections, which literature has indicated to be associated with audiovestibular events. Healthcare providers and vaccinees should be alert to potential audiovestibular complaints after COVID-19 vaccination. Our analysis highlights the importance of using large real-world datasets to gather reliable evidence for public health decision making.

Shoulder injury following COVID-19 vaccine administration: a case series and proposed diagnostic algorithm.

BACKGROUND: Shoulder Injury Related to Vaccine Administration (SIRVA) is a preventable adverse event following incorrect vaccine administration, which can result in significant long-term morbidity. There has been a notable surge in reported cases of SIRVA as a rapid national population-based COVID-19 immunization program has been rolled out across Australia. METHODS: Surveillance of Adverse Events Following Vaccination in the Community (SAEFVIC) in Victoria identified 221 suspected cases of SIRVA following the commencement of the COVID-19 vaccination program, reported between February 2021 and February 2022. This review describes the clinical features and outcomes of SIRVA in this population. Additionally, a suggested diagnostic algorithm is proposed, in order to facilitate early recognition and management of SIRVA. RESULTS: 151 cases were confirmed as SIRVA, with 49.0% having received vaccines at state vaccination centers. 75.5% were suspected incorrect administration site, with most patients experiencing shoulder pain and restricted movement within 24 hours of vaccination, lasting on average 3 months. CONCLUSION: Improved awareness and education regarding SIRVA is imperative in a pandemic vaccine roll-out. The development of a structured framework for evaluating and managing suspected SIRVA will aid in timely diagnosis and treatment, essential to mitigate potential long-term complications.

Autoresuscitation and pheochromocytoma multisystem crisis in a dog.

OBJECTIVE: To describe the clinical course of a dog with a pheochromocytoma multisystem crisis that exhibited autoresuscitation after cardiac arrest. CASE SUMMARY: An approximately 10-year-old male neutered terrier mix dog presented for collapse. Abdominal imaging was suggestive of a pheochromocytoma, and clinical pathology data and thoracic imaging suggested the presence of a multisystem crisis. The dog developed cardiopulmonary arrest that was followed by autoresuscitation. NEW OR UNIQUE INFORMATION PROVIDED: To the authors' knowledge, this is the first report of autoresuscitation in a dog. The phenomenon may have been associated with a pheochromocytoma multisystem crisis.

A Classification Framework to Assess Ecological, Biogeochemical, and Hydrologic Synchrony and Asynchrony.

Ecosystems in the Anthropocene face pressures from multiple, interacting forms of environmental change. These pressures, resulting from land use change, altered hydrologic regimes, and climate change, will likely change the synchrony of ecosystem processes as distinct components of ecosystems are impacted in different ways. However, discipline-specific definitions and ad hoc methods for identifying synchrony and asynchrony have limited broader synthesis of this concept among studies and across disciplines. Drawing on concepts from ecology, hydrology, geomorphology, and biogeochemistry, we offer a unifying definition of synchrony for ecosystem science and propose a classification framework for synchrony and asynchrony of ecosystem processes. This framework classifies the relationships among ecosystem processes according to five key aspects: 1) the focal variables or relationships representative of the ecosystem processes of interest, 2) the spatial and temporal domain of interest, 3) the structural attributes of drivers and focal processes, 4) consistency in the relationships over time, and 5) the degree of causality among focal processes. Using this classification framework, we identify and differentiate types of synchrony and asynchrony, thereby providing the basis for comparing among studies and across disciplines. We apply this classification framework to existing studies in the ecological, hydrologic, geomorphic, and biogeochemical literature, and discuss potential analytical tools that can be used to quantify synchronous and asynchronous processes. Furthermore, we seek to promote understanding of how different types of synchrony or asynchrony may shift in response to ongoing environmental change by providing a universal definition and explicit types and drivers with this framework.

Propofol infusion-like syndrome in a dog.

An 8-year-old, spayed female Chihuahua mixed breed dog was presented for dyspnea and was subsequently mechanically ventilated. Propofol was utilized as part of the anesthetic protocol. The dog developed rhabdomyolysis, myoglobinuria, cardiac arrhythmias, liver enzyme elevation, and methemoglobinemia. Propofol was discontinued and N-acetylcysteine was administered after which the clinical signs resolved.

Syndrome s'apparentant à l'infusion de propofol chez un chien. Un chien Chihuaha mâle castré de race croisée âgé de 8 ans a été présenté pour de la dyspnée et a été subséquemment soumis à une ventilation mécanique. Le propofol a été utilisé dans le cadre du protocole anesthésique. Le chien a développé de la rhabdomyolyse, de la myoglobinurie, de l'arythmie cardiaque, une élévation des enzymes hépatiques et de la méthémoglobinémie. Le propofol a été discontinué et de la N-acétylcystéine a été administrée après la résolution des signes cliniques.(Traduit par Isabelle Vallières).

Magnetic resonance imaging-the Aberdeen perspective on developments in the early years.

From the beginnings of medical imaging with radioactivity, an account is given of the development in Aberdeen of CT scanners in nuclear medicine, and their clinical value, leading to the present-day gamma-cameras. Early animal work with electron magnetic resonance is described, which developed into a programme towards nuclear magnetic resonance of water in body tissues. The 1974 NMR image of a mouse, using the nuclear medicine experience, led to a quest to build the first clinically useful whole-body MRI. The work of other teams is outlined, and the steps which led to successful diagnostic images being made with the Aberdeen machine in 1980. The welcome from the medical fraternity, and the output of the multinational medical imaging companies, has led to the present-day, worldwide use of the MRI technique.

The contribution of medical physicists and doctors in Aberdeen to the evolution of modern medical imaging--SPECT, PET and MRI, 1965-1992.

From the beginnings of medical imaging with radioactivity, an account is given of the development in Aberdeen of Computed Tomography (CT) scanners in Nuclear Medicine, and their clinical value, leading to present-day gamma-cameras. The introduction and clinical use of the cyclotron and Positron Emission Tomography (PET) imager in Aberdeen, has led to a national programme for the cancer patients in Scotland. Early animal work with electron magnetic resonance, which developed into a programme towards nuclear magnetic resonance of water, and then to a quest to build the first clinically-useful whole-body MRI, is described. Successful diagnostic images obtained with it have led to the present-day worldwide use of the MRI technique.

The evolution of medical imaging: from Geiger counters to MRI--a personal saga.

This article traces the evolution of medical imaging, from the crude images of the thyroid gland obtained using Geiger and scintillation counters, to the automatic scanners built to image brain tumors and organs, to gamma cameras, to digital imaging. A computed tomography scanner built in Aberdeen in the late 1960s led to the present-day gamma-camera tomographs, the main workhorse of nuclear medicine. The gradual evolution of the steps needed for clinical magnetic resonance imaging (MRI) are described, along with the rapid development of this novel form of body imaging. A brief account is also given of the present-day use of MRI in clinical medicine worldwide, with some modern cutting-edge applications, and its possible future.