ABSTRACT
A 25-year-old white man presented with acute multiple sclerosis manifested by right blindness, difficulty urinating, and paresthesias and weakness of both legs. Retinal examination revealed a distal occlusion of the descending branch of the superior temporal arteriole leading to an area of retinal ischemia of the right eye. The optic disc was edematous, and there were focal areas of periphlebitis. All retinal signs resolved in three weeks, and the only abnormality that persisted was a pale right optic disc. The finding of small arteriolar disease is unusual and may represent another possible pathogenetic mechanism in multiple sclerosis.
Subject(s)
Arterial Occlusive Diseases/complications , Multiple Sclerosis/complications , Retinal Artery , Adult , Arterial Occlusive Diseases/pathology , Arterioles/pathology , Blindness/etiology , Blindness/pathology , Fluorescein Angiography , Humans , Male , Retinal Diseases/complications , Retinal Diseases/pathologyABSTRACT
A 6-year-old boy with a diagnosis of acute myeoblastic leukemia in remission developed iris infiltration accompanied by uveitis, hypopyon, and vitreous hemorrhage, which was initially unilateral, later becoming bilateral. Pathologically, the eyes showed leukemic infiltrates in the conjunctiva, episclera, sclera, ciliary body, trabecular meshwork, canal of Schlemm, choroid, vitreous, and the iris. Leder stain studies showed positive esterase activity, indicating granulocytic sarcoma. Granulocytic sarcoma may appear intraocularly as iris nodules. These iris nodules may be the initial manifestation of granulocytic leukemia.
Subject(s)
Eye Neoplasms/pathology , Iris/pathology , Leukemia, Myeloid, Acute/pathology , Antineoplastic Agents/therapeutic use , Child , Exophthalmos/complications , Hemorrhage/complications , Humans , Leukemia, Myeloid, Acute/complications , Leukemia, Myeloid, Acute/drug therapy , Male , Uveal Diseases/complications , Uveal Diseases/diagnosis , Uveal Diseases/pathology , Uveitis/complications , Vitreous BodyABSTRACT
A patient is reported in whom bilateral optic neuritis developed following an influenza vaccination. From complete blindness (absence of light perception) in one eye, the patient's vision returned to normal following steroid treatment.
Subject(s)
Blindness/etiology , Influenza Vaccines/adverse effects , Optic Neuritis/etiology , Blindness/diagnosis , Blindness/drug therapy , Fluorescein Angiography , Humans , Male , Middle Aged , Optic Neuritis/diagnosis , Optic Neuritis/drug therapy , Prednisone/therapeutic use , Scotoma/etiology , Visual Acuity , Visual FieldsABSTRACT
Visual acuity in a 17-year-old girl who took norethindrone with mestranol (Ortho-Novum) for eight months decreased to 6/9 (20/30) in the left eye. Ophthalmoscopically, retinal edema was temporal to the disk and white plaques were in each of two branches of cilioretinal artery. A superior centrocecal scotoma corresponding to the area of edema was present. After the patient discontinued use of the drug, visual acuity improved to 6/6 (20/20).
Subject(s)
Arterial Occlusive Diseases/chemically induced , Contraceptives, Oral/adverse effects , Retinal Artery , Adolescent , Arterial Occlusive Diseases/complications , Arterial Occlusive Diseases/diagnosis , Edema/diagnosis , Edema/etiology , Female , Fluorescein Angiography , Humans , Retinal Diseases/diagnosis , Retinal Diseases/etiology , Visual AcuityABSTRACT
A case of bilateral microhaemangiomas of the pupillary borders in a 69-year-old woman is described. When first seen she presented with acute angle closure glaucoma and spontaneous hyphaema. Photographs and iris fluorescein angiography are presented and microhaemangiomas are discussed.
