ABSTRACT
Management of patients receiving oral anticoagulant therapy was assessed in general practice and a dedicated hospital anticoagulant clinic. The demographic characteristics of patients in both groups were similar, as were the indications for anticoagulation therapy and the duration of treatment. General practice patients were reviewed significantly more frequently, with a median interval of 16 days compared with 42 days for hospital patients (P < 0.001). Twenty four per cent of general practice visits and 26% of hospital attendances resulted in an alteration to the warfarin dosage. Overall, 52% of general practice thrombotest results lay within the ranges recommended by the British Society for Haematology, compared with 45% of hospital results (P < 0.001). There was no difference in the rate of complications in general practice and the hospital clinic. In this study, the anticoagulant control achieved in a general practice setting was superior to that in a dedicated hospital outpatient clinic, although control was far from ideal in either setting.
Subject(s)
Anticoagulants/therapeutic use , Cardiovascular Diseases/drug therapy , Aged , Family Practice , Female , Hospitals, Special , Humans , Male , Middle Aged , Outpatient Clinics, Hospital , Prothrombin Time , ScotlandSubject(s)
Acidosis/etiology , Alcoholism/complications , Ketosis/etiology , Adult , Female , Humans , Substance Withdrawal SyndromeABSTRACT
A case is described of a patient who developed local cutaneous hypersensitivity soon after commencing treatment with monocomponent insulins (MCI). This appears to be the first record of such a case.
Subject(s)
Drug Eruptions/etiology , Insulin/adverse effects , Adult , Female , Humans , Injections, Subcutaneous , Insulin/administration & dosage , Skin TestsABSTRACT
A study of the growth patterns of 19 children with chronic asthma, whose growth had become retarded while they were receiving regular treatment with prednisolone, showed that this trend was reversed after the substitution of corticotrophin.
Subject(s)
Adrenocorticotropic Hormone/therapeutic use , Asthma/complications , Growth Disorders/chemically induced , Prednisolone/adverse effects , Adolescent , Adrenocorticotropic Hormone/administration & dosage , Adrenocorticotropic Hormone/adverse effects , Asthma/drug therapy , Beclomethasone/therapeutic use , Body Height/drug effects , Child , Child, Preschool , Chronic Disease , Female , Growth/drug effects , Humans , Male , Prednisolone/administration & dosage , Time FactorsSubject(s)
Adrenocorticotropic Hormone/therapeutic use , Asthma/drug therapy , Prednisolone/therapeutic use , Adolescent , Adrenal Glands/physiopathology , Adult , Aged , Asthma/blood , Asthma/physiopathology , Child , Chronic Disease , Female , Growth Disorders/chemically induced , Growth Disorders/drug therapy , Humans , Hydrocortisone/blood , Hypothalamus/physiopathology , Insulin , Male , Middle Aged , Pituitary Gland/physiopathology , Prednisolone/adverse effectsSubject(s)
Lung Diseases/chemically induced , Sulfasalazine/adverse effects , Adult , Colitis, Ulcerative/drug therapy , Eosinophilia/chemically induced , Female , Humans , Lung Diseases/diagnosis , Lung Diseases/diagnostic imaging , Physical Exertion , Radiography , Recurrence , Spirometry , Sulfasalazine/therapeutic use , Vital CapacityABSTRACT
The hypothalamo-pituitary-adrenal axis has been assessed in 17 asthmatic children before and after long-term prednisolone therapy was changed to daily corticotrophin. In 14 of the 17 children the plasma corticosteroid concentration exceeded 15 mug/100 ml within five days of starting corticotrophin. No exacerbation of asthmatic symptoms occurred during conversion. The plasma corticosteroid response to insulin-induced hypoglycaemia was normal in four children about six weeks after conversion to corticotrophin, took up to 36 months to become normal in nine, and remained abnormal in one child throughout the period of the trial.
