Mechanisms of therapeutic change after psychedelic treatment in OCD.

Novel treatments are required for the 30-50% of individuals with obsessive-compulsive disorder (OCD) who remain resistant to first-line pharmacological and psychotherapeutic treatments. Recent pilot data suggest benefit from psilocybin-assisted psychotherapy (PAP) and from imagery rescripting (ImRs). We explore psychological mechanisms of change underpinning both interventions that appear to allow for reprocessing of negative emotions and core beliefs associated with past aversive events. A next critical step in PAP is the development of psychotherapeutic frameworks grounded in theory. We propose that basing PAP on an ImRs framework may provide synergistic benefits in symptom reduction, modification of core beliefs, and value-based living.

Single-dose psilocybin for treatment-resistant obsessive-compulsive disorder: A case report.

Classic psychedelics, such as psilocybin, act on the brain's serotonin system and produce striking psychological effects. Early work in the 1950s and 1960s and more recent controlled studies suggest benefit from psychedelic treatment in a number of conditions. A few case reports in recreational users and a single experimental study suggest benefit in patients with obsessive-compulsive disorder (OCD), but careful clinical data and long-term follow-up have been lacking. Here we describe a case of a patient with refractory OCD treated with psilocybin and followed prospectively for a year, with marked symptomatic improvement. We provide qualitative and quantitative detail of his experience during and after treatment. Improvement in OCD symptoms (YBOCS declined from 24 to 0-2) was accompanied by broader changes in his relationship to his emotions, social and work function, and quality of life. This individual was an early participant in an ongoing controlled study of psilocybin in the treatment of OCD (NCT03356483). These results are preliminary but promising, motivating ongoing investigations of the therapeutic potential of appropriately monitored and supported psychedelic treatment in the treatment of patients with obsessions and compulsions.

Delivering Imagery Rescripting via Telehealth: Clinical Concerns, Benefits, and Recommendations.

PURPOSE OF THE REVIEW: Delivery of psychological therapies via telehealth has increased with the emergence of the COVID-19 pandemic. Therapists may be hesitant in moving to telehealth when delivering therapies targeting memories of traumatic experiences. This paper collates the clinical experiences of clinicians and clients who have delivered or received imagery rescripting, respectively, via telehealth across a range of clinical presentations, and describes key clinical considerations and recommendations. RECENT FINDINGS: It is important to consider perceived and real safety; practical and technological issues; therapeutic alliance; depth of emotional processing; and dissociation. There was support for the delivery of imagery rescripting via telehealth being no less effective than face-to-face delivery; however, telehealth delivery was not a viable option for many clients during COVID-19 lockdowns who were living in high density housing, old houses with thin walls, or with some complex disorders.

Imagery rescripting as an adjunct clinical intervention for obsessive compulsive disorder.

Novel adjunct psychological techniques are needed for the large number of patients with OCD who remain symptomatic despite the effective implementation of standard evidence-based treatments. The aim of this study was to examine the efficacy of imagery rescripting (ImRs), an established technique for the treatment of traumatic stress, as a treatment for OCD symptoms that were not responsive to standard exposure and response prevention (ERP). Thirteen patients completed a baseline assessment followed by a control intervention that involved discussion of an aversive memory linked with the onset of OCD symptoms. Treatment then involved provision of 1-6 ImRs sessions; ImRs continued until patients achieved a 35% reduction in symptoms, as measured using the Y-BOCS one week after each treatment. Patients were followed up one and three months after the treatment completion. Twelve out of thirteen patients achieved ≥35% improvement in Y-BOCS. Of these patients, six required only a single ImRs session, while the remaining six patients required 2-5 ImRs sessions to achieve a clinically significant change. Lower baseline Y-BOCS predicted improvement after a single treatment session. ImRs may be a useful adjunct for treatment-resistant OCD associated with past aversive experiences, especially when symptomatology remains within the mild-moderate range after standard ERP.

An etiological model of perfectionism.

OBJECTIVE: Perfectionism has been recognized as a transdiagnostic factor that is relevant to anxiety disorders, eating disorders and depression. Despite the importance of perfectionism in psychopathology to date there has been no empirical test of an etiological model of perfectionism. METHOD: The present study aimed to address the paucity of research on the etiology of perfectionism by developing and testing an etiological model using a sample of 311 clients seeking treatment. RESULTS: Structural equation modeling showed a direct relationship between high Parental Expectations and Criticism, and Perfectionism. There was also an indirect relationship between Parental Bonding and Perfectionism that was mediated by core schemas of disconnection and rejection. Finally, it was found that Neuroticism had both an indirect relationship, which was mediated by core schemas, and a direct relationship with perfectionism. CONCLUSIONS: The study provided the first direct test of an etiological model of perfectionism to date. Clinical implications include investigating whether the inclusion of etiological factors in the understanding and treatment of perfectionism is effective.