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Antimicrob Agents Chemother
; 59(10): 6501-5, 2015 Oct.
Article
in English
| MEDLINE
| ID: mdl-26239977
ABSTRACT
The pharmacokinetics and bone concentrations of oritavancin were investigated after a single intravenous dose was administered to rabbits. The pharmacokinetic profile of oritavancin in rabbits showed that it is rapidly distributed to bone tissues, with concentrations remaining stable for up to 168 h, the last measured time point. Based on these findings, further evaluation of oritavancin for the treatment of infections in bone tissues is warranted.