ABSTRACT
Purpose of the study: The investigation of clinical and laboratory parameters that characterize the pathogenetic connections of association of ulcerative lesions of the gastrointestinal tract and hypertension as work-related diseases among workers of locomotive brigades. Materials and methods: 192 railway workers were examined. The level of general clinical and biochemical parameters in the blood serum were investigated. Results: Due to the syntopy of duodenal ulcers and (or) the stomach and hypertension on the background of the negative impact of harmful factors of production the abnormalities in the vascular endothelium with signs of systemic inflammation are revealed. Conclusion: The identified parameters can be considered as an early predictor of formation of hypertension as well as a comorbid flow of duodenal ulcers and (or) of the stomach and hypertension, assessing it as work-related diseases.
Subject(s)
Duodenal Ulcer , Hypertension , Occupational Diseases , Railroads , Stomach Ulcer , Adult , Comorbidity , Duodenal Ulcer/blood , Duodenal Ulcer/epidemiology , Duodenal Ulcer/physiopathology , Female , Humans , Hypertension/blood , Hypertension/epidemiology , Hypertension/physiopathology , Male , Middle Aged , Occupational Diseases/blood , Occupational Diseases/epidemiology , Occupational Diseases/physiopathology , Stomach Ulcer/blood , Stomach Ulcer/epidemiology , Stomach Ulcer/physiopathologyABSTRACT
The article discusses the development of occupational pathologies of the digestive system and it is associated with dyslipidemia. Selected the most informative indicators for timely identification of metabolic «targets¼ of damage in workers in chemical production of methanol.
Subject(s)
Chemical Industry , Chemical and Drug Induced Liver Injury , Dyslipidemias , Methanol/therapeutic use , Occupational Exposure/adverse effects , Adult , Chemical and Drug Induced Liver Injury/blood , Chemical and Drug Induced Liver Injury/epidemiology , Chemical and Drug Induced Liver Injury/pathology , Dyslipidemias/blood , Dyslipidemias/chemically induced , Dyslipidemias/epidemiology , Dyslipidemias/pathology , Female , Humans , Male , Middle AgedABSTRACT
The authors proved relationship between congenital abnormalities in children and influence of chemical factors (methanol and formaldehyde production) on the parents. Higher risk of congenital abnormalities was seen: PR = 5.6 (chi2 = 3.54; p = 0.00001), EF = 0.95. These disorders could be connected with work conditions--exceeded MAC for methanol 3.9-fold, that for formaldehyde--2.4-fold.
