[FACTORIAL ANALYSIS IN PROGNOSTICATION OF INFECTIOUS COMPLICATIONS AFTER SIMULTANT OPERATIVE INTERVENTIONS FOR BILIARY CALCULOUS DISEASE].

Prognostication of postoperative complications, having a certain high risk of occurrence in surgical treatment of biliary calculous disease, using laparoscopic and open access, peculiarly while performing simultant operative interventions, may promote the treatment efficacy rising in such patients. A multifactorial disperse analysis, using Statistica 6 for Windows (StatSoft), was applied for prognostication of risk for the infectious complications occurrence while a simultant operative interventions conduction for biliary calculous disease. The indices, which, in accordance to the pathophysiological processes character, may influence the postoperative complications occurrence rate, were analyzed. During conduction of this procedure, a great quantity of the parameters, which were determined in the patients, were transformed to a lesser quantity of independent causes. In the one cause a several variables were cojoined, which, as a rule, correlate with each other closely. On a subsequent stage a sum of the points of the prognosis causes for the risk of the postoperative purulent complications occurrence, as the points sum for the status severity and the operative intervention severity, were calculated. A prognostical validity of the algorithm proposed was tested in clinical conditions, its significance was estimated.

[APPLICATION OF MINIINVASIVE INTERVENTIONS UNDER ULTRASONOGRAPHIC CONTROL FOR NONPARASITIC HEPATIC CYSTS].

The results of treatment of 21 patients, suffering nonparasitic hepatic cysts, using laparoscopic draining and puncture under ultrasonographic control, were analyzed. Minimal traumaticity of the intervention, absence of necessity to apply general anesthesia, low rate of postoperative morbidity (7.1%), reduction of duration of the patients stationary treatment down to (3.3 ± 0.61) days, reduction of economic wastes on the treatment constitute the advantages of such method.

[TREATMENT MODALITIES OF THE FOREGUT HEMORRHAGES WHILE PERFORMING ENDOSCOPIC MONITORING].

Complex clinical examination was done in 107 patients, in whom gastrointestinal hemorrhage (GIH) of various etiology, have had occurred. Special attention was drawn toward early conduction of esophagogastroduodenofibroscopy, as a leading instrumental method, permitting to reveal a GIH source, its character and degree of hemostasis in accordance to J. Forrest scale. The patients state severity while hemorrhage from the foregut presence was estimated in accordance to routine principles, depending on the circulating blood volume deficiency. The structure algorithm for the patients' management, in accordance to which treatment tactic must be selected individually, permitting to improve the quality of the medical help delivery for the patients, was elaborated.

[APPLICATION OF MICROJEJUNOSTOMY IN SURGICAL PRACTICE].

Microjejunostomy was performed to 12 patients in surgical department in 2013-2014yrs with the objective of decompression of initial portions of a small bowel and nutritivEesupport achievement. While performing primary operative intervention decompressiornwas applied in 4 patients, and while relaparotomy --n 8. Application of method of asmall bowel drainage have provided its adequate decompression and was not accom pnied by additional trauma of the structures drained. This method may constitutEealternative for duodenostomy.

[EXPERIENCE OF RELAPAROTOMY APPLICATION IN SURGICAL TREATMENT OF THE ABDOMINAL CAVITY ORGANS DISEASES].

During 2011 - 2014 yrs in Surgical Clinic of The First City Clinic (Poltava) a relaparotomy was performed in 127 patients. There was established, that relaparotomy constitutes the only one procedure for such life threatening states, as intraabdominal bleeding, ileus in a decompensation stage, eventration, progressing peritonitis, abdominal compartment syndrome stages III - IV. The rate of relaparotomy application after performance of urgent operative interventions is bigger than after planned operations (ratio 4:1). Individual estimation of a state and choice of optimal surgical tactics during primary and secondary operative interventions are needed to improve the results of treatment.

[Dependence of the operation stress degree from the kind of operative intervention for an acute cholecystitis in the patients with high operative-anesthesiological risk].

The results of comparison between the operation stress degree in various kinds of surgical interventions, performed for an acute cholecystitis, using determination of cortizol, prolactin and glucose content before the operation, intraoperatively and postoperatively in 50 patients, are adduced. There was established, that the largest (in 5.3 times) and the most durable (more than 24 hours) intr erative raising of the cortizol level in the blood serum was noted in patients, to whom open cholecystectomy (OCH) was done, and the minimal (in 2.2 times) and the least durable (up to 1 hour)--while performing transcutaneous transhepatic draining (TTD) of gallbladder under ultrasonographic control. While performance of laparoscopic cholecystectomy (LCH) there was noted the most pronounced intraoperative raising of prolactin level (in 3.6 times) and more rapid its lowering (during 24 hours) in comparison with such while the OCH performance (during 72 hours). In TTD there was observed the minimal intraoperative inhancing of the prolactin level (in 2.3 times) and its duration (during 1 hour) postoperatively. The above mentioned have witnessed, that while TTD of gallbladder performance stimulation of the anterior hypophysis is significantly lesser, than while LCH and OCH.

[Peculiarities of the blood microcirculation in the anterior abdominal wall in patients with excessive body mass].

Investigation was conducted, using laser Doppler flowmetry (LDF) with the help of LAKK-02 analizator, with the objective to improve the results of surgical treatment and prophylaxis of complications in the postoperative wound healing in patients, suffering concomitant obesity. Characteristic disorders of microcirculation in soft tissues of the anterior abdominal wall in the operative intervention region were analyzed. There were examined 31 patients, suffering obesity stages I-III, their body mass index was (39.11 +/- 0.79) kg/m2 at average. Microcirculation disorders in soft tissues of the anterior abdominal wall have caused worsening of the postoperative period course in the patients. LDF is a highly informative noninvasive method, which have to be used trustworthy for estimation of a microcirculation bed state in the patients, suffering obesity.

[Biochemical markers in diagnosis and prognosis of obturative jaundice]. / Biokhimichni markery v diahnostytsi ta prohnozuvanni perebihu obturatsiinoï zhovtianytsi.

The results of complex examination and treatment of 175 patients with obturative jaundice of different genesis were analyzed Especial attention have been devoted to interaction of specific enzymes: aminotransferases, alkali phosphatase and gamma-glutamiletranspeptidase. It was established some connection of the activity of these enzymes in obturative jaundice and liver functionally-morphologic state. This had been confirmed by facts of laboratory investigations date. Comparison of these indexes will promote the increase of diagnostic informativity, that can be used as one of diagnostic and prognostic criterions.

[Clinical-diagnostic estimation of carbohydrates metabolism in obturation jaundice]. / Kliniko-diahnostychna otsinka zmin obminu vuhlevodiv pry obturatsiinii zhovtianytsi.

Complex examination of 175 patients with obturation jaundice was conducted, peculiar attention was spared to the carbohydrates metabolism changes, characterizing hepatic state. It was established, that in obturation jaundice in the liver there are occurring inflammatory changes and disturbances of all kinds of metabolism, including that of carbohydrates, severity of which depends on duration of jaundice, the concurrent diseases presence, they shows lowering of the glucose and glycogen level in the blood, as well as the hepatic glycogen content, that's why they may be applied as a complex of prognostic criterions for the disease course. An early conduction of operative treatment, elimination of the biliary ducts impassability promote the rehabilitation period shortening and the hepatic functional activity normalization.