[Application hemostatic drug in capillary-parenchymatous bleeding]. / Applikatsionnoe sredstvo gemostaza pri kapilliarno-parenkhimatoznom krovotechenii.

Specific activity of a new hemostatic drug thrombocol was studied in experiments. Laboratory rabbits were used for management of experimental capillary-parenchymatous hemorrhage. The action of thrombocol was compared with hemostatic effect of other drugs: carbocol, combutek-2, super-4 (USA), collastipt (Germany), collagen sponge (Germany). It was found that thrombocol was highly hygroscopic, showed good adhesion to wounded surface, high plasticity and better hemostatic effect compared with other collagen-containing drugs.

[Determination of the luminol-dependent chemiluminescence of granulocytes]. / Opredelenie liuminolzavisimoi khemiliumnestsentsii granulotsitov.

The authors have defined the optimal conditions for the determination of granulocyte luminol-dependent chemiluminescence (LDCL) in normal donors; the granulocytes have been isolated from small volumes of blood. Granulocytic LDCL has been studied in granulocyte exposure to zymosan, zymosan-activated serum, phorbol-myristate acetate, and FMLP (formyl-L-methionyl-leucyl-phenylalanine) synthetic tripeptide. Significant individual differences in the granulocyte activities in normal subjects have been revealed.

[Effect of antioxidants of the 3-hydroxypyridine class on cyclic 3', 5'-adenosine monophosphate phosphodiesterase activity]. / Vliianie antioksidantov iz klassa 3-oksipiridina na aktivnost' fosfodiésterazy tsiklicheskogo 3', 5'-adenozinmonofosfata.

It was shown that derivatives of oxypyridine inhibit activity of 3,5-AMP phosphodiesterase I and II from the rabbit heart. 2-ethyl-6-methyl-3-oxypyridine and proxypheine inhibited 3,5-AMP phosphodiesterase activity in human lymphocytes substantially higher than theophilline widely used in clinical practice.

[Concentration of cyclic adenosine-3',5'-monophosphate in the tissues and its excretion in the urine of rats during ontogenesis]. / Vmist tsyklichnoho adenozyn-3',5'-monofosfatu v tkanynakh i ekskretsiia ioho z secheiu u shchuriv v ontohenezi

The intracellular content of cyclic adenosine 3',5'-monophosphate (cAMP) in the liver and epididymal fat as well as excretion of cAMP with urea were studied in rats at the age of 1, 3, 12 and 24 months. No statistically significant age changes were found in the intracellular content of cAMP in the tissues. A decreases in the intensity of cAMP excretion with urea in the 12-month rats as compared to the one-month ones is statistically significant.

[Adenylate cyclase activity in human nasal polyps under conditions of stimulation of serotonin biosynthesis (in vitro)]. / Adenilattsiklaznaia aktivnost' polipov nosa cheloveka v usloviiakh stimuliatsii biosinteza serotonina (in vitro)

Nasal polyp tissue possess adenylatecyclase activity. Under conditions of incubation of nasal polyps with the use of reserpine (an activator of serotonin synthesis in this tissue) there can be observed a statistically significant increase of adenylatecyclase activity. During the first minutes of the polyp incubation with reserpine the activity of the enzyme rose ten-fold. Participation of the adenylatecyclase system at the initial stages of morphological and biochemical differentiation, accompanying serotonin biosynthesis in human nose polyps was confirmed.

[Cyclic adenosine-3',5'-monophosphate level in donor plasma]. / Uroven' tsiklicheskogo adenozin-3',5'-monofosfata v plazme donorov

The method of competitive protein binding was applied to the study of content of cyclic adenosine-3',5'-monophosphate (cAMP) in donor plasma one day before and immediately after the donation of 200 ml of blood. The work was performed by Gilman's radiochemical method. Two types of reaction of donors to donorship were revealed: without any changes and with the changes of the cAMP level. In accordance with these reactions the donors were divided into two subgroups--the stable and the reactive ones. In repeated donors the cAMP level was higher than in the primary ones, and the reactive ones. In repeated donors the cAMP level was higher than in the primary ones, and at the time of blood recovery it increased even more particularly among persons of "reactive" type. In primary donors of reactive type the cAMP content before the blood donation was either below or over the mean value and either increased or decreased to the mean level after the blood loss.