[A neurophysiological analysis of the mechanisms of neuroendocrine regulation in stress and under the antistress action of the delta sleep-inducing peptide]. / Neirofiziologicheskii analiz mekhanizmov neiroéndokrinnoi reguliatsii pri stresse i antistressovom deistvii peptida del'ta-sna.

In the article one can find analysis of modern theories about mechanisms of neuroendocrine regulation under stress, influence of steroid hormones and neuropeptides (delta-sleep-inducing peptide) on the functional state of hypothalamic reticular limbic structures of the brain. Special attention is paid to the analysis of mechanisms of creation of integrative processes under aggressive-defensive behaviour and roles of biologically active factors in the regulation of the processes.

[The current concepts of the mechanisms of the interaction of the CNS and the hypophyseal-adrenal system under the ordinary conditions of the activities of living]. / Sovremennye predstavleniia o mekhanizmakh vzaimodeistviia TsNS i gipofizarno-nadpochechnikovoi sistemy v obychnykh usloviiakh zhiznedeiatel'nosti.

Elucidation of mechanisms of hormonal influence on the CNS function is one of the primary concerns of neuroendocrinology. The study of the action of hormones on nervous centres is hampered by extraordinary complexity of morphological and functional organization of the CNS. Inquiry into the influence of hormones on separate structures of the hypothalamo-reticulo-limbic complex regulating emotional state and motivated behavior, allows to approach the task. Consideration is given to the present knowledge about effects of adrenal cortex steroids and peptides (delta-sleep, etc.) on functional state of various brain structures and their role in integrative processes in the central nervous system. Special attention is attributed to discussions of current understanding of the CNS-hypophysial/adrenal interactions in normal environments, and to formation of inter-central interactions with assistance of hormones and neuropeptides.

[Electroencephalographic analysis of inter-central relations in hypothalamo-reticulo-limbic brain structures during treatment with corticosteroids and neuropeptides]. / Elektroéntsefalograficheskii analiz mezhtsentral'nykh vzaimootnoshenii gipotalamoretikulolimbicheskikh struktur mozga pri deistvii kortikosteroidov i neiropeptidov.

Intercentral relations between hypothalamus, limbic system and reticular formation were studied in rabbits and rats under systemic and central action of DSIP, ACTH, corticosteroids and stress (aggressive-defensive behaviour). The results obtained demonstrate changes in the adrenal cortex resulting from stress-inducing adrenocortical hormone content. The increase was achieved by the rise in ACTH level resulting in corticosteroid level elevation (endogenous elevation-aggressive behaviour) and by corticosteroid injections (exogenous elevation). Correlation analysis of structural interrelations after ACTH and corticosteroid injections demonstrated an increased correlation between hypothalamo-reticular-limbic structures. DSIP was shown to have an opposite effect. Correlation analysis revealed the potentials for the formation of new functional interrelations between hypothalamo-reticular-limbic structure in the motivation of aggression (stress) and the levels of corticosterone and DSIP. DSIP action depends on the initial corticosteroid blood level and is more marked in stress-inducing concentrations.

[Comparative analysis of changes in intercentral relations of the brain as a result of administration of delta-sleep peptide and ACTH]. / Sravnitel'nyi analiz izmenenii mezhtsentral'nykh vzaimootnoshenii mozga pri deistvii peptida delta-sna i AKTG.

Elucidation of the mechanisms of the DSIP effect on the CNS functional state is one of the leading problems of neuroendocrinology. The investigation of DSIP physiological properties as antistress factor in systemic mechanisms of emotional stress is of great interest. The purpose of our studies was to investigate the character of changes in intercentral interrelationships among hypothalamus, limbic system and reticular formation in augmentation of corticosteroids level up to the stressful one. We also studied the character of changes in intercentral interrelationship under the DSIP effect. The latter depends on the initial level of corticosteroids in the blood and is more obvious at the stress level. DSIP, ACTH and steroid hormones facilitate the process of the self-organization of the brain as well as the formation of the current behavioral responses.

[Mechanisms of self-regulation and interaction of the central nervous system and of the hypophyseal-sexual system]. / Mekhanizmy samoreguliatsii i vzaimodeistviia tsentral'noi nervnoi sistemy i gipofizarno-polovoi sistemy.

Literary review on the problem of regulation of the sexual glands functions by the central nervous system and the effect of the sex and tropine hormones on the brain formation activity is given. In experiments on rabbits and rats sexual steroid hormones have been shown to alter the bioelectric activity mainly in the structures of the Nauta septo-hypothalamo-hippocampal circle and the amygdalar circle of the limbic system. The data obtained suggested the steroid hormones participation in the processes of self-regulation of the cerebral reticulo-hypothalamo-limbic complex's functions by means of involving the limbic system circles into the process of reverberation.

[The influence of sex hormones on the bioelectric activity of the cortex and hypothalamo-reticulo-limbic structures of the brain]. / Vliianie polovykh gormonov na bioélektricheskuiu aktivnost' kory i gipotalamo-retikulo-limbicheskikh struktur golovnogo mozga

In rabbits and rats, sexual steroid hormones were shown to alter bioelectric activity mainly in the structures of the Nauta septo-hypothalamo-hippocampal circle and the amygdalar circle of the limbic system. The data obtained suggested participation of steroid hormones in the processes of self-regulation of the cerebral reticulo-hypothalamolimbic complex's functions by means of involving into the process of reverberations in the limbic system's circles.