[ROLE OF ANIMALS AND HUMAN BEINGS IN THE SPREAD OF TRICHINOSIS IN THE KURSK REGION].

Trichinosis is natural focal invasion in the Kursk Region. Porkworms (Trichinella) circulate in natural biocenoses among wild carnivorous mammals, wild boars, and rodents. Trichinosis cases are recorded in synanthropic animals. Carnivorous mammals form the basis for the parasitic system of trichinosis. The animals are infected with Trichinella through carnivorism, necrophagy, and cannibalism. The transport Trichinella vectors, necrophagous insects, naturally play an insignificant role-in the spread of trichinosis. Trichinella infection in animals occurs more commonly through necrophagia and cannibaism during winter months. Not only animals, but also man, play a great role in the spread of trichinosis. Infested wild and synanthropic aninals inhabiting the Kursk Region may carry the risk for Trichinella infection in the population.

[The effect of treatment on the course of invasion by Hymenolepis nana and the state of its population in white mice]. / Vliianie lecheniia na techenie invazii i sostoianie populiatsii Hymenolepis nana u belykh myshei.

Leukinferon administered before infection affects the development of a Hymenolepis nana population in the murine intestine: in rodents, its defective forms predominate over mature ones. Leukinferon caused cell prestimulation in the immune system and activation of nonspecific defense factors. The cytokine properties of the agent appear to have an impact on parasitic growth and development by leading to formation of defective Hymenolepis forms directly and indirectly through the host's body due to the prestimulation and enhancement of nonspecific defense. There may be a concurrent influence of these factors on H. nana embryos in the murine intestine.

[Approaches to the combined therapy of helminthiases with leukinferon and etiotropic preparations]. / Podkhody k kombinirovannoi terapii gel'mintozov leikinferonom i étiotropnymi preparatami.

The results of therapy with anthelmintics in combination with leukinferon show either higher efficiency of anthelmintics (medamin) or their same efficiency (albendazole). The outcomes of combined treatment of infected animals with anthelmintics and leukinferon are different and associated with the time of leukinferon administration as to the tissue stages of parasitic development, with the host's sensitivity and susceptibility to helminth.

[The effect of leukinferon on the invasive process in experimental helminthiases]. / Vliianie leikinferona na invazionnyi protsess pri éksperimental'nykh gel'mintozakh.

Two models of helminthiases (nippostrongyliasis and trichocephaliasis) were used to reveal the therapeutical activity of leukinferon (LF). In experimental nippostrongyliasis, the efficacy of LF was similar to that in infected young rats and mice whose sensitivity and resistance to infections were different. In the model of trichocephaliasis, the therapeutical effect of leukinferon was noticeably higher in C57BL/6 mice resistant to T. muris than in sensitive mice strains. In intact animals, LF brought about similar lymphocytic prestimulation depending on their sensitivity to infection. The infection itself also caused increased LF levels comparable to those observed during LF administration to intact animals. LF-induced differences in cell prestimulation were especially great as infection progressed in animals whose sensitivity to host helminths was opposite. The levels of splenocytic LF was higher in resistant hosts (non-inbred mice with nippostrongyliasis and C57BL/6 mice with trichocephaliasis) that under the similar experimental conditions in animals (rats with nippostrongyliasis and DBA/2j mice with trichocephaliasis sensitive to host helminths).