ABSTRACT
Data are presented on yak platelet ultrastructure (in comparison with human platelets), and on acetylsalicylic acid influence on the platelet ultrastructure and function. The following species features of this animals are associated with their adaptation to high-altitude hypoxia: organization of alpha-granules, mitochondria, the contractile system (microtubes, F-actin), ovoid form of platelets. Acetylsalicylic acid influences the yak platelet plasma membrane inducing fragmentation, which is attended by a rise in the total number of platelets, by the appearance of a great number of microforms, and by the reduction of functional activity. The above changes remained up to 11 days from the beginning of the drug action.
Subject(s)
Aspirin/pharmacology , Blood Platelets/drug effects , Models, Biological , Platelet Aggregation/drug effects , Altitude , Animals , Blood Platelets/physiology , Blood Platelets/ultrastructure , Cattle , Cell Membrane/drug effects , Cell Membrane/ultrastructure , Kyrgyzstan , Microscopy, Electron , Platelet Aggregation/physiologyABSTRACT
Ultrastructural peculiarities of blood plates and state of the thrombocytic line of hemostasis have been studied in yaks (Bos grunniens), the Tibet subspecies, living in the Kirghiz mountains at the altitude more than 3.200 m. As a control 6 cows (Bos taurus), constantly living at the altitude of 760 m, have been taken. Stereological analysis of the volume of thrombocytic alpha-granules and of the volume of blood plates in the yaks has been performed. Ultrastructure of thrombocytes in the yaks possesses certain essential peculiarities (polymorphism of mitochondria, difference in the structure of alpha-granules). A conclusion is made on adaptive specificity of thrombocytes in animals living at high altitude.
