[Effectiveness of combined use of a lipid peroxidation inhibitor and a lymphatic drainage stimulant in intensive care of acute myocardial infarct]. / Effektivnost' kombinirovannogo primeneniia ingibitora perekisnogo okisleniia lipidov i stimuliatora limfaticheskogo drenazha serdtsa pri intensivnoi terapii ostrogo infarkta miokarda.

The efficacy of intensive care for acute myocardial infarction making use of mannitol and vitamin E was under study. The results evidence a marked clinical effect of both the drugs. ECG demonstrates that in the majority of cases the necrotic process is arrested and no grave complications develop after such treatment, and the ECG parameters normalize. Measurements of serum enzymes activities and lipid peroxidation parameters have shown their more rapid normalization in the test group as against the reference group. Administration of these drugs within the first hours of the disease development improves the efficacy of intensive care for acute myocardial infarction.

[Stimulation of the lymphatic drainage in intensive care of acute myocardial infarct]. / Stimuliatsiia limfaticheskogo drenazha pri intensivnoi terapii ostrogo infarkta miokarda.

Under study was reogluman efficacy in the acute period of myocardial infarction. Timely administration of the drug to myocardial infarction patients was conductive to reduction of the duration and intensity of the painful syndrome, was associated with a reduction and even disappearance of congestion in the lungs within the first 2 days. These changes were paralleled by a more rapid normalization of the activities of all the blood serum lysosomal enzymes in the patients treated with reogluman as against the reference patients.

[Use of rheogluman in the acute period of myocardial infarction]. / Primenenie reogliumana v ostrom periode infarkta miokarda.

The efficacy of rheogluman was evaluated in 55 patients with acute myocardial infarction. ECG mapping recordings in 35 leads showed that an earlier positive dynamics in sigma ST, sigma Q, and sigma R was significantly observed in patients treated with rheogluman than in untreated patients. These data indirectly indicated a reduction in the ++peri-infarct zone in the acute period of myocardial infarction. The serum concentrations of lysosomal enzymes (creatine phosphokinase, lactate dehydrogenase, aspartate aminotransferase, alanine amino-transferase) became normal earlier in the rheogluman-treated patients than in the controls. This fact may be regarded as a protective effect of the drug on the formation of a necrotic focus.

[The efficacy of the combined use of a lipid peroxidation inhibitor and a stimulator of the lymphatic drainage of the heart in the treatment of the acute period of myocardial infarction]. / Effektivnost' kombinirovannogo primeneniia ingibitora perekisnogo okisleniia lipidov i stimuliatora limfodrenazha serdtsa v terapii ostrogo perioda infarkta miokarda.

The effect of combined use of mannitol and alpha-tocopherol on the course and outcome of acute myocardial infarction has been studied. The results have shown that these drugs have a marked clinical effect. The ECG findings show that in the majority of cases the drugs prevented further development of necrotic process and the onset of life-threatening complications and accelerated normalization of the ECG parameters. The determination of serum enzyme activity and lipid peroxidation indexes has revealed a more prompt normalization of the above parameters in patients of the test group than in the controls. The use of the drugs under study in the earliest period of the disease development promotes the efficacy of the therapy performed.

[Effect of lymph-stimulating drugs on the clinical manifestations and parameters of lipid metabolism in patients with post-infarction cardiosclerosis and angina pectoris]. / Deistvie limfogonnykh preparatov na klinicheskie proiavleniia i pokazateli lipidnogo obmena u bol'nykh s postinfarktnym kardiosklerozom i stenokardiei.

As many as 64 patients with coronary heart disease (CHD) were examined. They were divided into 3 groups: (1) control subjects; (2) patients on supplementary rheogluman and (3) those on supplementary haemodesum (neocompensan). Their status was assessed from the frequency and intensity of anginal attacks, the magnitude of changes in lipid metabolic parameters prior to and following the therapy. Rheogluman and haemodesum were ascertained to have a favourable effect on the course of CHD, rheogluman producing a more beneficial effect. Supplementation of rheogluman to the treatment of CHD resulted in better correction of lipid metabolic disturbances in postinfarction cardiosclerosis to a greater extent than in angina. The hypolipidemic effect of haemodesum was slightly weaker than that of rheogluman. Rheogluman contributes to better correction of lipid parameters mainly in Type IIb hyperlipidemia, whereas haemodesum is more effective in type IIa.

[Effect of heparin, obsidan and rheogluman on lymph coagulating activity and flow rate in acute myocardial infarction]. / Vliianie geparina, obsidana i reogliumana na svertyvaiushchuiu aktivnost' i skorost' toka limfy pri ostrom infarkte miokarda.

Experiments were conducted on dogs to study the effect of heparin, obsidan, and rheogluman on the rate of lymph flow from the thoracic duct and the lymph coagulation potential in acute myocardial infarction. Rheoglumin produced the most marked lymph stimulating effect. The effect of heparin and partly that of rheogluman on lymph coagulability is mediated.

[The effect of pharmacological agents on the rate of lymph outflow and on blood and lymph toxicity in acute myocardial infarct]. / Vliianie nekotorykh farmakologicheskikh sredstv na skorost' limfoottoka, toksichnost' krovi i limfy pri ostrom infarkte miokarda.

In experiments on rabbits it was found that acute myocardial infarction (AMI) was associated with a disorder of the drainage function the lymphatic system and a drastic increase of the lymph toxicity. The administration of propranolol (obsidan), amiodaron (cordaron), lidocaine (xycaine), trimecaine (mesocaine), nitroglycerin, panangin and heparin exerted the pronounced stimulating action on the lymph outflow rate. Strophanthin-K, corglycon and digo in possessed the moderate lymphogenic effect. Novocainamide (procainamide), verapamil (isoptine) and panangin exerted no influence on the lymph outflow rate. The administration of the above mentioned drugs in the initial period of AMI sharply increased the toxic properties of the lymph; subsequently the lymph toxicity gradually decreased and was less than in control (in AMI treated with drugs).

[Changes of electrolyte metabolism, acid-base equilibrium, and coagulation of blood and lymph in acute myocardial infarction]. / Izmeneniia élektrolitnogo obmena, kislotno-shchelochnogo krovi i limfy pri ostrom infarkte miokarda.

Experiments were conducted on dogs to study disorders of the acid-base equilibrium (ABE), electrolyte metabolism, and the blood and lymph coagulation potential in different periods after the development of acute myocardial infarction (AMI). It was found that AMI modelling in dogs leads to marked changes of the values of the electrolyte metabolism, ABE, and coagulation of blood and lymph. Earlier and deeper disorders of many values occur in the lymph. Comparison of the data obtained shows on the main that the shifts in the blood and lymph are of a similar direction. The differences in the changes in both humoral media are quantitative in character.

[Effect of obsidan on metabolic processes in the blood and lymph in acute myocardial infarction]. / Vliianie obzidana na metabolicheskie protsessy v krovi i limfe pri ostrom infarkte miokarda.

The effects of obsidan on lactate and glucose levels, the indices of ABB and electrolyte metabolism in blood and lymph at various times after development of the acute myocardial infarction were studied experimentally on dogs. It was stated that the earliest and most expressed changes of biochemical values were observed in the lymphatic system, thus pointing to its important role in the resorption and transport of the metabolic products from ischaemic myocardium. The use of obsidan during the development of acute myocardial infarction corrects substantially the disturbed metabolic processes in the blood and lymph.

[Endogenous intoxication of the body in acute myocardial infarct during lymph stimulation]. / Endogennaia intoksikatsiia organizma pri ostrom infarkte miokarda v usloviiakh limfostimuliatsii.

It was stated experimentally in dogs that the elevation of the lymph toxicity was more expressed than that of the blood in acute myocardial infarction. The shortening of the half-life period of paramecia evidenced the above mentioned fact. The injection of the lymphogogue preparations (obsidan, heparin, rheogluman) after coronary artery occlusion resulted in distinct rise of blood and lymph toxicity in early periods because of the "washing out" of toxic products from the ischemic myocardium, followed by normalization that had been more quicker than in controls.

[Stimulation of cardiac lymphatic drainage by obzidan, heparin and rheogluman in acute myocardial ischemia]. / Stimuliatsiia limfaticheskogo drenazha serdtsa obzidanom, geparinom i reogliumanom pri ostroi ishemii miokarda.

The state of the lymphatic heart perfusion has been studied experimentally on dogs with intact myocardium (control 1), with acute myocardial ischemia (AMI) model (control 2) and during injection of heparin, rheogluman and obsidan in AMI. It has been stated that AMI induces acute distress of the lymphatic heart perfusion system occurring at the first minutes after the onset of the focal myocardial ischemia. Heparin, rheogluman and obsidan demonstrated selective stimulating effect on the function of the lymphatic myocardial system.

[Drainage of the thoracic duct and changes in myocardial lymph drainage under conditions of electrothermocoagulation of the coronary artery]. / Drenirovanie grudnogo protoka i izmeneniia limfodrenazha v miokarde v usloviiakh élektrotermokoaguliatsii koronarnoi arterii.

It was demonstrated in dog experiments that the drainage function of the heart lymphatic system and coagulation of the central lymph are disturbed in acute myocardial infarction. Drainage of the thoracic duct with diversion of the flow of the toxic lymph fails to correct the diminished rate of lymph flow in the myocardium and does not prevent the increase of the hypercoagulation shift in the lymph. It is concluded that lymph stimulation and correction of the disorder of the lymph coagulation potential are necessary for effective pathogenetic treatment of myocardial infarction.

[Changes in lymph coagulation in experimental myocardial infarction after mammary-coronary artery anastomosis]. / Izmeneniia limfokoaguliatsii pri éksperimental'nom infarkte miokarda posle nalozheniia mammarno-koronarnogo anastomoza.

In the experiment on dogs, it was established that creation of the ++mammary-coronary anastomosis in myocardial infarction didn't eliminate the impairment of the lymph outflow in the myocardium, which resulted from the increase in the lymph coagulability.

[Lipid metabolism and lymph coagulability in the postresuscitation period]. / Lipidnyi obmen i svertyvaemost' limfy v postreanimatsionnom periode.

The values of lipid metabolism and lymph coagulation in the restoration period after resuscitation were studied in experiments on rabbits. A clear correlation between the values was revealed. Increase of concentration of total lipids and of lipid fractions was accompanied by increase of the lymph coagulation potential, which led to disturbed tissue drainage of lymph and was one of the important causes of the development of postresuscitation complications. The elaboration of pathogenetic therapy for regulation of lipid metabolism and lymph coagulation in the postresuscitation period is necessary.

[The blood and lymph electrolyte composition in the postresuscitation period]. / Elektrolitnyi sostav krovi i limfy v postreanimatsionnom periode.

The electrolyte composition (Na+, K+, Ca2+, Mg2+) of blood serum and lymph was studied in experiments on 17 mongrel dogs in the postresuscitation period after clinical death. The concentration of these electrolytes reduced in the postresuscitation period. Comparison of data obtained in study of blood and lymph showed the revealed changes to be of one trend. The above-said is evidence of the expediency of including in the complex of postresuscitation therapeutic and preventive measures means for normalizing the electrolyte composition of not only the blood but also the lymph.

[The structuro-functional state of the ischemic myocardium under the action of a terrilitin-nicotinic acid mixture in animal experiments]. / Strukturno-funktsional'noe sostoianie ishemizirovannogo miokarda pod vliianiem smesi terrilitin-nikotinovaia kislota v éksperimente.

Histochemical evidence of the activity and distribution of glycolysis redox enzymes, tissue respiration and terminal oxidation pattern (dehydrogenase of lactic, malic, succinic and isocitric acids, NAD-N- and NADPh-N-ase, cytochrome oxidase) as well as the levels of the major carbohydrates (glycogen, neutral aminopolysaccharides, glucose) were experimentally studied in the cardiomyocytes of myocardial necrotic, perinecrotic and intact areas in the control and in the experimental material under the administration of terrilitin-nicotinic acid mixture. It was stated that the use of aforementioned mixture contributed to the retention of enzymatic activity and optimal levels of energy formation in the cardiomyocytes of the marginal infarction zone and noticeably prevented the destructive involvement of the considered area as well as the impairment of functional activity of oscillating cardiomyocytes. Therefore, the application of the mixture improved the outcome prognosis in acute myocardial infarction.

[Approaches to the control of lymphogenic metastatic spread of tumors]. / Puti vozdeistviia na limfogennoe metastazirovanie opukholi.

Lymphopoiesis stimulating drugs were injected into the blood of rabbits bearing Brown-Pearce transplantable tumor. It was found that treatment with mannitol targeted on osmoregulation mechanisms and terrilytin--on blood and lymph coagulation intensified the lymphogenic migration of tumor cells. When used in an experimental series involving endolymphic transplantation of tumor cells, the said drugs promoted tumor cell passage from lymph to blood, which resulted in an increased number of metastasis-bearing animals. It was also found that the promoting effect may be counteracted by preliminary endolymphic injection of a fat-soluble antitumor preparation. Lymphopoiesis and lymph flow stimulation in conjunction with thoracic duct draining may be used for removal of tumor cells from the lymphatics.