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1.
Front Pediatr ; 8: 614097, 2020.
Article in English | MEDLINE | ID: mdl-33585365

ABSTRACT

Introduction: Cryoanalgesia has been recently described as alternative technique for immediate and persistent pain treatment after pectus excavatum repair. Cryoanalgesia has the potentiality to reduce analgesic consumption and length of hospitalization. However, cryoanalgesia has not been standardized yet: the previous reports describe different techniques and systems and include only small series. In Europe, no reports on cryoanalgesia for pectus repair have been published so far. Materials and Methods: This is a prospective single center pilot study performed in adolescents undergoing minimally invasive pectus excavatum repair with a new cryoanalgesia system, using a probe designed specifically for thoracoscopy. This new double lumen probe has the theoretical advantage of freezing only in its tip, so reducing the risk of complications. Results: Seven patients undergoing pectus excavatum repair were treated with cryoanalgesia performed with the new probe. No complications of cryoanalgesia were reported. Total consumption of morphine during hospital stay was between 0.1 and 0.35 mg/kg, with no side effects reported. Mean time to discharge was 2.4 days. All patients reported a good pain control with a fair need of rescue medications for pain relief during the first week after discharge, and a very good pain control without need of rescue medications during following weeks. Conclusions: Our pilot study showed that the new cryoanalgesia device is efficacious in terms of pain control, hospital stay and resumption of post-operative activities. The cryoprobe designed allowed an easy and safe maneuver. A prospective trial is needed to better define the risks and benefits of this technique.

2.
Pediatr Blood Cancer ; 64(2): 330-335, 2017 02.
Article in English | MEDLINE | ID: mdl-27578550

ABSTRACT

BACKGROUND: Ultrasound-guided (USG) cannulation of the brachiocephalic vein (BCV) is gaining worldwide consensus for central venous access in children. This study reports a 20-month experience with this approach in children. METHODS: All patients who underwent percutaneous USG central venous catheter (CVC) positioning in the BCV between August 2013 and March 2015 have been included. Devices inserted during this period were open-ended, either single or double-lumen tunneled CVC. Our series was divided into three consecutive study periods in order to determine the relative incidence of repositioning and complications. RESULTS: During the study period, a total of 95 patients underwent 109 CVC insertions in the BCV. The median length of CVC duration was 230 days for a total of 23,212 catheter days. No major intraoperative complications occurred. Overall rate of CVC-related postoperative complications requiring repositioning or precocious removal was 0.90 per 1,000 catheter days and involved 21 CVC (19%, 95% confidence interval 13-28). These included 18 dislodgments, two infections, and one malfunction. Double-lumen CVCs represented the only significant risk factor for complications (52% complications-three per 1,000 catheter days). CONCLUSION: USG supraclavicular cannulation of the BCV represents a safe approach for central line placement in children. It proved to be versatile, as it can be used in premature infants as well as in adolescents. Provided it is adopted by operators experienced in USG cannulation, we strongly suggest to resort to this approach as a first-line choice in children undergoing tunnelled central line placement for long-lasting therapy.


Subject(s)
Brachiocephalic Veins/diagnostic imaging , Catheterization, Central Venous/methods , Neoplasms/surgery , Postoperative Complications , Ultrasonography, Interventional/methods , Adolescent , Adult , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Infant , Infant, Newborn , Male , Neoplasms/diagnostic imaging , Prognosis , Prospective Studies , Risk Factors , Time Factors , Young Adult
3.
Paediatr Anaesth ; 24(9): 980-6, 2014 Sep.
Article in English | MEDLINE | ID: mdl-24824018

ABSTRACT

BACKGROUND: The use of isotonic electrolytic solutions for the intraoperative fluid management in children is largely recognized, but the exact composition still needs to be defined. OBJECTIVES: The primary objective of this randomized controlled open trial was to compare the changes in chloride plasma concentration using two intraoperative isotonic fluid regimens (Sterofundin vs. normal saline, both added with 1% of glucose) in children undergoing major surgery. Secondary objectives were to compare changes in other electrolytes, renal function, and the occurrence of hypoglycemia. METHODS: Children aged between 1 and 36 months, scheduled for major surgery, were randomized to receive Sterofundin or saline during the intraoperative time. Children with preoperative electrolyte abnormalities, hemodynamic instability, and severe renal or hepatic dysfunction were excluded. The primary outcome was the Δ of Cl(-) (Δ = change in plasma concentration between post- and pre-infusion), and secondary outcomes included Δ of other electrolytes and intraoperative hypoglycemia. RESULTS: A total of 240 patients were included in the two study sites and randomized to receive Sterofundin plus 1% glucose or normal saline plus 1% glucose, in a open fashion (229 were finally analyzed). Δ of Cl- and Mg++ was statistically less relevant in patients who received intraoperative Sterofundin, and Δ of the other electrolytes was comparable between the two study groups. Relative risk of hyperchloremia was significantly higher when large volumes were infused (over than 46.7 ml·kg(-1) ), regardless of type of crystalloid infused. Hypoglycemia occurred in two of 229 patients. CONCLUSIONS: Sterofundin is safer than normal saline in protecting young children undergoing major surgery against the risk of increasing plasma chlorides and the subsequent metabolic acidosis.


Subject(s)
Fluid Therapy/methods , Sodium Chloride/administration & dosage , Sodium Chloride/blood , Water-Electrolyte Balance/drug effects , Child, Preschool , Female , Glucose/administration & dosage , Humans , Infant , Isotonic Solutions , Kidney/drug effects , Kidney Function Tests/statistics & numerical data , Male , Organic Chemicals/administration & dosage , Organic Chemicals/blood , Treatment Outcome
4.
J Pediatr Surg ; 47(10): e23-7, 2012 Oct.
Article in English | MEDLINE | ID: mdl-23084226

ABSTRACT

Perineal sepsis is a life-threatening complication of acute leukemia. Although conservative management (antibiotics, incision, and drainage, alone or in combination) is considered the criterion standard, it provides an outcome that is not fully satisfactory, with an overall mortality of roughly 30%. This report presents a case series of 4 children who underwent early defunctioning colostomy for the treatment of perineal sepsis during leukemia. This management proved to be successful and allowed prompt reestablishment of chemotherapy, thus improving overall results. Routine application of this "aggressive" management in these cases will presumably increase overall survival of children with leukemia.


Subject(s)
Colostomy/methods , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , Sepsis/etiology , Sepsis/surgery , Anal Canal , Child, Preschool , Female , Humans , Infant , Male , Perineum , Time Factors , Young Adult
5.
Paediatr Anaesth ; 22(11): 1080-6, 2012 Nov.
Article in English | MEDLINE | ID: mdl-22420528

ABSTRACT

OBJECTIVE: To present and compare with literature our experience with an electronic anesthesia-related incident reporting form as a quality control measure at Gaslini Children's Hospital over a 19-month period. METHODS: All events that occurred between March 2009 and September 2010 were recorded. We adopted an electronic reporting form included in the online recording process of every anesthetic procedure. Events were divided into near misses and adverse events. Adverse events were further divided into incidents, minor events, and major events. Patients were divided into three age-groups: <1, between 1 and 3, and >3 years. RESULTS: A total of 12,850 anesthetics were performed. Eight (0.06%) near misses and 108 (0.8%) adverse events were reported. Adverse events occurred more frequently in infants. Of 108 events, 35 (32.4%), 61 (56.5%), and 12 (11.1%) were classified as incidents, minor, and major events, respectively. Of all the adverse events, 66 (61%) were respiratory, 27 (25%) organizational, six (5%) drug-related, four (4%) cardiocirculatory, and five (5%) miscellaneous. CONCLUSIONS: Infants were at the highest risk to experience adverse events. Although experimental electronic incident reporting proved to be feasible, there is reason to suspect that there was underreporting of near misses. Overreporting of near miss events may be enhanced by easier and more straightforward reporting forms as well as by better education for anesthetic providers about the importance of recognizing and reporting near misses.


Subject(s)
Anesthesia/adverse effects , Risk Management/statistics & numerical data , Adolescent , Adult , Age Distribution , Child , Child, Preschool , Female , Humans , Infant , Male , Prospective Studies , Young Adult
7.
Pediatr Surg Int ; 27(8): 839-46, 2011 Aug.
Article in English | MEDLINE | ID: mdl-21442425

ABSTRACT

BACKGROUND: Minimally invasive surgery is being increasingly applied to inflammatory bowel diseases (IBDs). Few pediatric series from selected research have been described to date. This study describes a unicentric experience of laparoscopic treatment of children with IBDs. MATERIALS AND METHODS: All consecutive patients with IBDs between February 2006 and February 2010 who underwent laparoscopic treatment were included. We reviewed notes and recorded demographic data, indications, perioperative management, surgical details, length of surgery, complications, postoperative management, length of hospitalization and functional outcome. RESULTS: We performed 25 procedures on 16 patients (12 ulcerative colitis, 3 Crohn's disease, and 1 indeterminate colitis). Median age was 12 years. A total of 50% patients underwent elective surgery; 11 underwent staged laparoscopic subtotal colectomy (LSTC) followed by J-pouch ileorectal anastomosis (JPIRA). Three patients underwent straight LSTC + JPIRA. All procedures included protective ileostomy. Length of surgery ranged between 120 and 380 min depending on the procedure (LSTC ± JPIRA). No conversion was required. Length of hospitalization ranged between 3 and 18 days. We observed six complications (24%) mainly represented by adhesions that were effectively treated laparoscopically. Ten patients were restored (ileostomy closure) and were assessed for continence that turned out to be good in 80%. CONCLUSIONS: Laparoscopy proved to be feasible, safe and effective for the treatment of IBD in children. Although we observed a relatively low incidence of complications, stoma site adhesions still remain the major issue, which can be effectively dealt with laparoscopically. Functional outcome as well as cosmesis is satisfactory. As results are encouraging, at present we prefer laparoscopy for the surgical treatment of IBD in pediatric patients.


Subject(s)
Colectomy/methods , Ileum/surgery , Inflammatory Bowel Diseases/surgery , Laparoscopes , Laparoscopy/methods , Rectum/surgery , Adolescent , Anastomosis, Surgical/methods , Child , Child, Preschool , Equipment Design , Female , Gastrointestinal Motility , Humans , Incidence , Inflammatory Bowel Diseases/physiopathology , Length of Stay , Male , Postoperative Complications/epidemiology , Retrospective Studies , Treatment Outcome
8.
Paediatr Anaesth ; 21(2): 128-35, 2011 Feb.
Article in English | MEDLINE | ID: mdl-21159021

ABSTRACT

BACKGROUND: Clonidine has the potential to significantly prolong the duration of caudal epidural anesthesia. We investigated the effect of the addition of clonidine to the MLAC of levobupivacaine in a randomized controlled dose-response trial. METHODS: A group of 120 children aged <6 years of age received caudal anesthesia with levobupivacaine and 1, 2, or 3 µg·kg(-1) of clonidine. The MLAC was determined according to a Dixon-Massey protocol. The primary outcome was effective surgical anesthesia. Secondary outcomes were the duration of postoperative analgesia, postoperative pain scores, clonidine side effects, and time to hospital discharge. RESULTS: The MLAC of caudal levobupivacaine was 0.106%, 0.077%, and 0.035% with 1, 2, and 3 µg·kg(-1) of clonidine, respectively. There were significant dose-dependent increases in median duration of analgesia. The incidence of delayed discharge, somnolence, and PONV was significantly increased in the 3 µg·kg(-1) of clonidine group. CONCLUSIONS: Clonidine produces a local anesthetic sparing effect with a dose-dependent decrease in levobupivacaine MLAC for caudal anesthesia. In addition, there is a dose-dependent prolongation of postoperative analgesia following lower abdominal surgery in children. A dose of 2 µg·kg(-1) of clonidine provides the optimum balance between improved analgesia and minimal side effects.


Subject(s)
Adjuvants, Anesthesia , Adrenergic alpha-Agonists/pharmacology , Analgesia, Epidural , Anesthesia, Caudal/methods , Anesthetics, Local/administration & dosage , Clonidine/pharmacology , Adrenergic alpha-Agonists/administration & dosage , Adrenergic alpha-Agonists/adverse effects , Anesthetics, Local/adverse effects , Anesthetics, Local/pharmacokinetics , Bupivacaine/administration & dosage , Bupivacaine/adverse effects , Bupivacaine/analogs & derivatives , Bupivacaine/pharmacokinetics , Child , Clonidine/administration & dosage , Clonidine/adverse effects , Dose-Response Relationship, Drug , Double-Blind Method , Female , Hernia, Inguinal , Humans , Levobupivacaine , Male , Orchiopexy , Postoperative Nausea and Vomiting/epidemiology , Preanesthetic Medication , Sample Size
9.
J Laparoendosc Adv Surg Tech A ; 19(6): 807-13, 2009 Dec.
Article in English | MEDLINE | ID: mdl-19405807

ABSTRACT

BACKGROUND: Neurologically impaired children (NIC) have a high risk of recurrence of gastroesophageal reflux (GER) following fundoplication. A postpyloric feeding tube may be useful when gastric emptying disorders occur; however, dislocation and difficulty in feeding management often require more aggressive procedures. Total esophagogastric dissociation (Bianchi's TEGD) is an alternative to the classic fundoplication procedure, whereas laparoscopic gastric bypass is a frequently performed procedure in morbid obesity, improving gastric outlet. AIM: The aim of this paper is to present a preliminary experience on the laparoscopic Roux-en-Y gastrojejunal bypass, associated with Nissen fundoplication and gastrostomy, to treat and prevent GER in NIC with gastric emptying disorders. MATERIALS AND METHODS: Eight neurologically impaired children underwent surgical treatment because of feeding problems and pulmonary complications. The procedure included: 1) hiatoplasty, 2) Nissen fundoplication, 3) 20-cm Roux-en-Y gastrojejunal anastomosis and jejuno-jejunal anastomosis, and 4) gastrostomy. RESULTS: All cases were fed on postoperative day 3 without any intraoperative complications. One case developed an obstruction of the distal anastomosis due to adhesion and needed reoperation. Outcome was clinically evaluated with serial upper gastrointestinal contrast studies and endoscopies. CONCLUSIONS: Laparoscopic proximal Roux-en-Y gastrojejunal diversion, without gastric resection, is a safe, feasible procedure that improves gastric emptying and reduces the risk of GER recurrence. Yet, long-term results still have to be evaluated.


Subject(s)
Cerebral Palsy/complications , Fundoplication , Gastric Bypass , Gastroesophageal Reflux/surgery , Gastrostomy , Laparoscopy , Cerebral Palsy/physiopathology , Cerebral Palsy/therapy , Child , Child, Preschool , Female , Gastric Emptying , Gastroesophageal Reflux/etiology , Humans , Male , Prospective Studies , Treatment Outcome
10.
J Laparoendosc Adv Surg Tech A ; 19 Suppl 1: S7-9, 2009 Apr.
Article in English | MEDLINE | ID: mdl-19260794

ABSTRACT

INTRODUCTION: The aim of this study is to present the "fast-track" experience in children who underwent colon resection. MATERIALS AND METHODS: Forty-six children who underwent laparoscopic colon resection were prospectively included in the study. Anomalies of colon innervation and inflammatory bowel disease represented the main surgical indications. RESULTS: Left colon/sigmoid resection was performed in 37, total colon resection was done in 5, and right colon resection in 4 children. Total colon resection was always associated to ileostomy. Anastomosis was performed in 41 cases. Patients were postoperatively monitored for pain, return to normal activity, feeding, bowel movements, and complications. Stool passage and oral feeding were started on postoperative day 1, and all patients were discharged before postoperative day 4. One child was readmitted the day after discharge because of an anastomotic leak. No other major complications were recorded. DISCUSSION: Minimally invasive surgery is safe and effective in pediatric colonic surgery and allows a fast recovery time (fast-track).


Subject(s)
Colon/surgery , Laparoscopy/methods , Adolescent , Child , Child, Preschool , Colectomy , Humans , Infant , Prospective Studies
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