ABSTRACT
Fasciola hepatica, a zoonotic liver fluke, can also cause disease in humans. Common symptoms are epigastric pain, upper abdominal pain and malaise. Fever and arthralgia are common in acute fascioliasis. Eosinophilia is the predominant laboratory finding, especially in patients with the acute form of the disease. Diagnosis and treatment is not easy, as physicians rarely encounter this disease, and effective drugs are not available in many countries. Human fascioliasis may be underestimated. Patients with eosinophilia and abdominal pain should be evaluated for F. hepatica infestation by parasitological, radiological and serological tests.
Subject(s)
Fascioliasis/diagnosis , Fascioliasis/drug therapy , Praziquantel/analogs & derivatives , Adult , Aged , Albendazole/therapeutic use , Animals , Antibodies, Helminth/analysis , Antiplatyhelmintic Agents/therapeutic use , Benzimidazoles/therapeutic use , Fasciola hepatica/drug effects , Fasciola hepatica/immunology , Fascioliasis/parasitology , Female , Humans , Male , Middle Aged , Praziquantel/therapeutic use , TriclabendazoleABSTRACT
Vancomycin-resistant enterococci are unusual etiologic agents of bacterial meningitis and pose significant therapeutic difficulties. We report the first confirmed case of nosocomial vancomycin-resistant Enterococcus faecium meningitis in Turkey. The patient was treated with chloramphenicol and cerebrospinal fluid cultures became negative, but clinical success was not achieved. We also review the previously reported cases of vancomycin-resistant Enterococcus faecium meningitis.
Subject(s)
Enterococcus faecium/drug effects , Enterococcus faecium/pathogenicity , Gram-Positive Bacterial Infections/drug therapy , Vancomycin Resistance , Adult , Anti-Bacterial Agents/therapeutic use , Cerebrospinal Fluid/microbiology , Chloramphenicol/therapeutic use , Cross Infection/drug therapy , Humans , Male , TurkeySubject(s)
Fascioliasis/epidemiology , Adult , Fascioliasis/physiopathology , Humans , Male , Middle Aged , Turkey/epidemiologyABSTRACT
With the participation of eight major reference hospitals in Turkey, 749 aerobic Gram-negative isolates obtained from 473 intensive care patients in 1997 were tested for their susceptibility to 13 commonly employed antibacterial agents. The frequency with which species were isolated and resistance rates were compared with data from the previous 2 years. Imipenem was the most active agent against the majority of isolates (75%), followed by ciprofloxacin, cefepime and amikacin. The per cent susceptibility to all antibiotics declined from 1995 to 1996. With the exception of imipenem, for which there was no change in resistance, the per cent susceptibility somewhat increased in 1997. However, it was still lower than in 1995.
Subject(s)
Anti-Bacterial Agents/pharmacology , Gram-Negative Bacteria/drug effects , Gram-Negative Bacterial Infections/epidemiology , Intensive Care Units , Drug Resistance, Microbial , Gram-Negative Bacteria/isolation & purification , Gram-Negative Bacterial Infections/microbiology , Humans , Microbial Sensitivity Tests , Population Surveillance , Turkey/epidemiologyABSTRACT
This study was carried out with the participation of eight hospitals in Turkey to determine the frequency of gram-negative bacteria isolated in intensive care units (ICU) and to compare their resistance rates to selected antibiotics. Aerobic gram-negative bacteria isolated from ICUs during 1996 were studied. Antibiotic susceptibilities to imipenem, ceftazidime, ceftazidime-clavulanate, ceftriaxone, cefotaxime, cefepime, cefodizime, cefuroxime, piperacillin/tazobactam, amoxycillin-clavulanate, gentamicin, amikacin and ciprofloxacin were determined by Etest. A total of 748 isolates were obtained from 547 patients. The majority of organisms were isolated from the respiratory (38.8%) and urinary tracts (30.9%). Pseudomonas spp. were the most frequently isolated gram-negative species (26.8%), followed by Klebsiella spp. (26.2%). Escherichia coli, Acinetobacter spp. and Enterobacter spp. were the other commonly isolated organisms. High resistance rates were observed for all antibiotics studied. Imipenem appeared to be the most active agent against the majority of isolates. Although resistance rates exceeded 50%, ciprofloxacin, cefepime and amikacin were found to be relatively effective. Extended-spectrum beta-lactamase (ESBL) production appeared to be a major mechanism of resistance to beta-lactam antibiotics. In contrast to ceftazidime-clavulanate, piperacillin/tazobactam showed poor activity against organisms thought to produce ESBL, suggesting the presence of an enzyme resistant to tazobactam action. This study has yielded high rates of resistance in aerobic gram-negative isolates from ICUs in Turkey. High resistance rates to all the other antibacterials studied leave imipenem as the only reliable agent for the empirical treatment of ICU infections in Turkey.
Subject(s)
Drug Resistance, Microbial , Gram-Negative Bacteria/drug effects , Hospitals , Humans , Intensive Care Units , Microbial Sensitivity Tests , beta-Lactamases/physiologyABSTRACT
Fulminant meningococcemia is a rare clinical form of meningococcal disease which has been frequently fatal. In this case report, two patients with fulminant meningococcemia which have been cured completely were presented and the related literature was examined.