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Bioorg Med Chem ; 12(9): 1991-4, 2004 May 01.
Article in English | MEDLINE | ID: mdl-15080902

ABSTRACT

A novel series of quinazolino-beta-carbolinone derivatives was synthesized and evaluated for their in vitro and in vivo anticancer activity. Many compounds have shown good in vitro activity in the range 1-8 microM concentration. Three of the compounds were further tested in nude mice bearing HT-29 colon cancer xenografts.


Subject(s)
Antineoplastic Agents/chemical synthesis , Antineoplastic Agents/pharmacology , Carbolines/chemical synthesis , Carbolines/pharmacology , Quinazolines/chemistry , Animals , Antineoplastic Agents/chemistry , Carbolines/chemistry , Cell Line, Tumor , Humans , Mice , Mice, Nude , Neoplasm Transplantation
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