[State of health of the population of the one out of oil and gas extraction regions of Kazakhstan].

Research is conducted in the city of Aktau ofMangystau area in 2009-2011. The state of health of adult population of the city of Aktau and quality of atmospheric air were studied. Results of works revealed positive dynamics of a natural increase of the population. There is noted a high rate of birth rate, however infantile mortality has tendency to the gain. There were established the structure and leading indices of the incidence among the male andfemale population. The impurity of atmospheric air by chemicals was shown to have the direct impact on health of urban population.

[Hygienic assessment of working conditions in the production of ferro-alloys].

This work is devoted to the study of conditions of the work of employees of the modern ferro-alloy production, which was performed in the framework of the evaluation of working places at the Open Joint-Stock Company «Ferrokhrom¼, which is part of Joint-Stock Transnational Company "Kazchrom". The studies were performed with account of the full range of the list of working places, both in the main and auxiliary shops. The work activity of the workers from leading professional groups was established to be conjugate of the impact of the complex of unfavorable factors of occupational environment and labor process. There are given comprehensive measures to improve working conditions and health maintenance in workers from leading professional groups.

[The role of anthropotechnogenic impact in shaping the allergic morbidity].

The paper gives information on the prevalence of allergic diseases in Aktobe depending on the level of an anthropotechnogenic load area. The findings indicate that children that the degree of immunodeficiency in persons living in different micro-areas of the city depends on the magnitude of environmental pollution. Among allergic diseases, pollinoses (58.6%) rank first, asthma (19.9%) and allergic rhinitis (15.6%) occupy the second and third places, respectively. At the same time, the incidence of allergic diseases is 21.2-30.3% of all cases in the areas near an industrial area and 9.1-12.1% in those maximally remote from it. The impact of environmental quality on the incidence of allergic diseases depends on gender and age.

[The content of metals in hair and blood in the child population of cities of Aktobe region].

The content of metal carcinogens in hair and blood in children's population in thee cities of Aktobe area has been studied. These data indicate that levels of carcinogens in children living in the Khromtau and Aktobe cities are 2 times higher than levels of carcinogens in children living in the Alga city.

[Immune homeostasis parameters in chromium production workers].

The authors studied immune homeostasis parameters in chromium production workers and presented changes in cellular, humoral immunity and sensibilization to chromium in main occupational groups of workers. Findings are that occupational contact with chromium compounds results in T-immune deficiency. Allergic tests also revealed higher sensibilization to 6-valent chromium.

[Combined influence of chemical and physical factors on health of workers engaged into chromium production].

The authors studied influence of chemical and physical factors in main production of chromium compounds plant on the workers' health. Patterns of morbidity formation in the workshops are defined.

[Effect of lead intoxication on chelate producing liver function and its regulation with enterosorption detoxification]. / Sostoianie kholatoobrazuiushchei funktsii pecheni pri svintsovoi intoksikatsii i vliianie na neë énterosorbtsionnoi detoksikatsii.

A total of 27 patients facing chronic lead intoxication was examined and treated by enteral absorption. Enteral absorption was proved to increase chelation, improve hepatic conjugation and excretion, reduce serum lead level, normalize some biochemical parameters and improve the general status in patients facing lead intoxication.

[The pathomorphological changes in the internal organs in experimental chronic red phosphorus poisoning]. / Patomorfologicheskie izmeneniia vo vnutrennikh organakh pri éksperimental'noi khronicheskoi intoksikatsii krasnym fosforom.

Experiments on 76 rats of both sexes exposed to red phosphorus revealed the morphologic changes in the body. Chronic red phosphorus poisoning (15 days, 1, 2, 3, 4 months) induces dystrophic changes and hyperemia in the examined viscera and brain. The first pathomorphologic changes appeared in the liver, stomach, small intestine, and as the intoxication period was prolonged they appeared in other internal organs and brain.

[The late sequelae of body exposure to phosphorus, fluorine and their derivatives (a review of the literature)]. / Otdalennye posledstviia vozdeistviia fosfora, ftora i ikh proizvodnykh na organizm (obzor literatury).

Presents data on mutagenic, gonadotoxic, embryotoxic and teratogenic activities of phosphorus, fluorine and their derivatives. The investigations have revealed the mechanisms of these chemical substances toxic action on the genetic apparatus, reproductive organs, progeny. The problem is interesting and needs further investigations.

["Layer" distribution of various gaseous chemical substances in the air during zinc electrolysis]. / O posloinom raspredelenii nekotorykh gazoobraznykh khimicheskikh veshchestv, vydeliaiushchikhsia v vozdushnuiu sredu pri élektrolize tsinka.

Studies performed at a zinc plant's electrolysis shop revealed a reason accounting for the uneven distribution of different chemical compounds in the working zone air. It was established that the 'layer' distribution of the chemical substances depended on the ir respective specific weights, which is important for hygienic assessments of occupational conditions.

[Modifying effect of nutrition on the mutagenic activity of phosphorus and fluorine compounds]. / Modifitsiruiushchee vliianie pitaniia na mutagennyi éffekt soedinenii fosfora i ftora.

The test animals were fed with low-grade food during 2-5 months under conditions of acute and chronic action of hydrogen phosphide and hydrogen fluoride induced by inhalation, that resulted in the pronounced impairment of the chromosomal apparatus of the bone marrow cells in the rats. A principal possibility has been established of modification of the hydrogen phosphide and hydrogen fluoride cytogenetic effect by the alimentary action. In particular, it has been found that the effect is significantly higher when the rats are fed with a low-grade ration than under conditions of balanced nutrition.

[Phospholipid composition of membrane lipids of hepatic subcellular structures in rats under the effects of different nutrition and phosphorus and fluorine compounds]. / Fosfolipidnyi sostav lipidov membran subkletochnykh struktur pecheni krys pri razlichnom pitanii i vozdeistvii soedineniiami fosfora i ftora.

A study was made of the phospholipid composition of the membranes of the rat liver nucleus, mitochondria and microsomes under the effect of different nutrition, hydrogen fluoride and phosphine. It was established that prolonged exposure to hydrogen fluoride and phosphine resulted in alterations of the phospholipid composition of the membranes of the liver nucleus, mitochondria and microsomes. The pattern of nutrition, the diet content of retinol, tocopherol, ascorbic acid and essential amino acids (lysine, methionine, threonine) determined not only the quantitative and qualitative composition of phospholipids but also the action of the foreign substances under study on the cell membranes. The enrichment of the diet with retinol, tocopherol, ascorbic acid and thiamine reduced the membrane-damaging action of hydrogen fluoride and phosphine.