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1.
Gan To Kagaku Ryoho ; 51(5): 579-581, 2024 May.
Article in Japanese | MEDLINE | ID: mdl-38881073

ABSTRACT

A 72-year-old male was referred with a 2-week history of diplopia. Following magnetic resonance imaging, an area of abnormal signal intensity was observed along the lateral ventricle, without any unusual findings at other sites. Cerebrospinal fluid cytology revealed abnormal lymphocytes with atypia, which were positive for CD20 and light-chain restriction, as detected by surface marker analysis, leading to a diagnosis of primary meningeal B-cell lymphoma. The patient underwent chemoradiotherapy and achieved a remission. While meningeal lymphoma is a rare occurrence, pathological tissue biopsy is considered the gold-standard diagnostic method. However, obtaining a biopsy sample from the tumor site can be challenging. In this case report, cytology and flow cytometry played a vital role in the diagnosis of meningeal lymphoma.


Subject(s)
Flow Cytometry , Meningeal Neoplasms , Humans , Male , Aged , Meningeal Neoplasms/diagnosis , Meningeal Neoplasms/pathology , Lymphoma, B-Cell/diagnosis , Lymphoma, B-Cell/pathology , Lymphoma, B-Cell/diagnostic imaging , Chemoradiotherapy , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Magnetic Resonance Imaging , Cytology
2.
Clin Case Rep ; 12(5): e8639, 2024 May.
Article in English | MEDLINE | ID: mdl-38736576

ABSTRACT

When chronic lymphocytic leukemia progressed to Richter syndrome, the coexistence of small and large lymphocytes was observed as a bone marrow finding. We consider this finding to be a clue for the progression of chronic lymphocytic leukemia to Richter syndrome.

3.
Cancer Rep (Hoboken) ; 7(3): e2036, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38517451

ABSTRACT

BACKGROUND: Cancer-related thrombotic microangiopathy (CR-TMA) is a rare type of Coombs-negative hemolytic anemia, which is caused by malignancy and has a poor prognosis. CASE: A 76-year-old female was referred to our hospital due to Coombs-negative hemolytic anemia, which was causing fatigue and dyspnea on exertion, accompanied by schistocytosis. A bone marrow examination demonstrated bone marrow carcinomatosis, and the tumor cells were morphologically suspected to be signet-ring cell carcinoma cells. As we failed to find the primary tumor site before the patient died, she was diagnosed with CR-TMA due to bone marrow carcinomatosis of unknown primary origin. Thrombotic thrombocytopenic purpura (TTP) was rapidly ruled out based on her PLASMIC score. In addition, immunohistochemical staining of a clot section of the bone marrow and tumor marker data were useful for narrowing down the likely primary tumor site. CONCLUSION: Although CR-TMA is an extremely rare phenomenon, clinicians who suspect CR-TMA should quickly rule out TTP and decide whether to provide appropriate chemotherapy or plan for palliative care.


Subject(s)
Anemia, Hemolytic , Carcinoma , Disseminated Intravascular Coagulation , Neoplasms, Unknown Primary , Peritoneal Neoplasms , Purpura, Thrombotic Thrombocytopenic , Thrombotic Microangiopathies , Female , Humans , Aged , Disseminated Intravascular Coagulation/etiology , Disseminated Intravascular Coagulation/complications , Purpura, Thrombotic Thrombocytopenic/complications , Purpura, Thrombotic Thrombocytopenic/diagnosis , Bone Marrow , Neoplasms, Unknown Primary/complications , Neoplasms, Unknown Primary/diagnosis , Thrombotic Microangiopathies/etiology , Thrombotic Microangiopathies/complications , Anemia, Hemolytic/complications
4.
Med Int (Lond) ; 4(1): 9, 2024.
Article in English | MEDLINE | ID: mdl-38283133

ABSTRACT

The present study reports the case of a patient with acute myeloid leukemia post-cytotoxic therapy (AML-pCT) that developed following chemotherapy for thymoma. A 64-year-old female patient underwent surgical resection for a mediastinal tumor and was diagnosed with stage IVa thymoma. She received chemotherapy, including carboplatin/etoposide, carboplatin/paclitaxel and amrubicin monotherapy. At 56 months following surgery, she developed blastosis and was diagnosed with AML-pCT. As demonstrated herein, although treatment for thymoma is associated with a markedly lower frequency of myeloid neoplasms post-cytotoxic therapy (MN-pCT) than treatment for other malignancies, such as breast carcinoma, it is important to be aware that MN-pCT may occur as a late complication of thymoma treatment.

7.
Biomolecules ; 13(3)2023 03 03.
Article in English | MEDLINE | ID: mdl-36979403

ABSTRACT

Remnant lipoproteins (RLs), which are typically present at high concentrations in patients with type 2 diabetes mellitus (T2DM), are associated with cardiovascular disease (CVD). Although an RL cholesterol homogeneous assay (RemL-C) is available for the measurement of RL concentrations, there have been no studies of the relationship between RemL-C and clinical parameters in T2DM. Therefore, we evaluated the relationships between RemL-C and CVD-related parameters in patients with T2DM. We performed a cross-sectional study of 169 patients with T2DM who were hospitalized at Kumamoto University Hospital. Compared with those with low RemL-C, those with higher RemL-C had higher fasting plasma glucose, homeostasis model assessment for insulin resistance (HOMA-R), total cholesterol, triglyceride, small dense low-density lipoprotein cholesterol (sdLDL-C), and urinary albumin-creatinine ratio; and lower high-density lipoprotein cholesterol, adiponectin, and ankle brachial pressure index (ABI). Multivariate logistic regression analysis showed that sdLDL-C and ABI were significantly and independently associated with high RemL-C. Although LDL-C was lower in participants with CVD, there was no difference in RemL-C between participants with or without CVD. Thus, RemL-C may represent a useful index of lipid and glucose metabolism, and that may be a marker of peripheral atherosclerotic disease (PAD) in male patients with T2DM.


Subject(s)
Cardiovascular Diseases , Diabetes Mellitus, Type 2 , Humans , Male , Cross-Sectional Studies , Cholesterol , Lipoproteins , Triglycerides , Cholesterol, LDL
8.
Gan To Kagaku Ryoho ; 50(12): 1347-1349, 2023 Dec.
Article in Japanese | MEDLINE | ID: mdl-38247079

ABSTRACT

A 72-year-old male patient, who had been on chemotherapy for the treatment of IgG-λ multiple myeloma, presented an enlargement of the testis 3 years and 5 months after the diagnosis. High orchiectomy was then performed, leading to the diagnosis of plasmacytoma. Due to residual disease, treatment with a combination of isatuximab and dexamethasone was initiated. The patient is currently under follow-up without recurrence. While testicular tumors are difficult to diagnose by imaging studies alone and extramedullary plasmacytomas rarely occur in the testis, pathological assessment is critical for treatment planning.


Subject(s)
Multiple Myeloma , Plasmacytoma , Testicular Neoplasms , Male , Humans , Aged , Plasmacytoma/surgery , Multiple Myeloma/drug therapy , Testicular Neoplasms/drug therapy , Testicular Neoplasms/surgery , Neoplasm, Residual
9.
Sci Rep ; 12(1): 17848, 2022 10 25.
Article in English | MEDLINE | ID: mdl-36284103

ABSTRACT

Hypouricemia in children including renal hypouricemia, which is a major cause of exercise-induced acute renal injury (EIAKI), is an important clinical problem, in addition to hyperuricemia. However, no large-scale studies of serum uric acid (UA) concentrations in the general pre-adolescent population have been carried out. We conducted a population-based cross-sectional study to measure the prevalences of hypouricemia and hyperuricemia and identify the associated factors. We analyzed 31,822 (16,205 boys and 15,617 girls) 9-10-year-old children who underwent pediatric health check-ups in Kagawa prefecture between 2014 and 2018. Hypouricemia and hyperuricemia were defined using serum UA concentrations of ≤ 2.0 mg/dL and ≥ 6.0 mg/dL, respectively. The prevalence of hypouricemia was 0.38% in both 9- and 10-year-old boys and girls, and was not significantly associated with age, sex, or environmental factors, including overweight. The prevalence of hyperuricemia was significantly higher in boys (2.7%) than in girls (1.9%), and was significantly associated with age, overweight, future diabetes risk, hypertriglyceridemia, low high-density lipoprotein-cholesterol, and liver damage, but not with high low-density lipoprotein cholesterol. Therefore, some pre-adolescent children in the general population in Japan showed hypouricemia. A means of identifying children with hypouricemia and lifestyle guidance measures for the prevention of EIAKI should be established.


Subject(s)
Acid-Base Imbalance , Hyperuricemia , Male , Adolescent , Female , Humans , Child , Hyperuricemia/epidemiology , Cross-Sectional Studies , Uric Acid , Prevalence , Overweight , Japan/epidemiology , Cholesterol, HDL , Cholesterol, LDL , Risk Factors
11.
Cancer Rep (Hoboken) ; 5(10): e1658, 2022 10.
Article in English | MEDLINE | ID: mdl-35715969

ABSTRACT

BACKGROUND AND CASE: We herein present a case of the co-occurrence of JAK2-mutated essential thrombocythemia (ET) with chronic lymphocytic leukemia (CLL) harboring the recurrent and rare whole-arm translocation, der(8;17)(q10;q10). The co-existence of lymphoproliferative neoplasms and myeloproliferative neoplasms is suggested to be a rare event. Under this condition, the lymphoproliferative disorder presents a clinically indolent course with a low-risk biological profile. However, the present case showed aggressive disease progression, reflecting a poor prognostic factor; that is, the loss of 17p caused by the whole-arm der(8;17)(q10;q10) translocation. CONCLUSION: The present case report emphasizes the importance of considering the involvement of a genetically poor prognostic factor, regardless of the co-occurrence of CLL and ET.


Subject(s)
Leukemia, Lymphocytic, Chronic, B-Cell , Thrombocythemia, Essential , Humans , Janus Kinase 2/genetics , Leukemia, Lymphocytic, Chronic, B-Cell/complications , Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis , Leukemia, Lymphocytic, Chronic, B-Cell/genetics , Thrombocythemia, Essential/complications , Thrombocythemia, Essential/diagnosis , Thrombocythemia, Essential/genetics , Translocation, Genetic
12.
Sci Transl Med ; 14(632): eaax7706, 2022 02 16.
Article in English | MEDLINE | ID: mdl-35171652

ABSTRACT

Cancer-specific cell surface antigens are ideal therapeutic targets for monoclonal antibody (mAb)-based therapy. Here, we report that multiple myeloma (MM), an incurable hematological malignancy, can be specifically targeted by an mAb that recognizes a ubiquitously present protein, CD98 heavy chain (hc) (also known as SLC3A2). We screened more than 10,000 mAb clones raised against MM cells and identified R8H283, an mAb that bound MM cells but not normal hematopoietic or nonhematopoietic cells. R8H283 specifically recognized CD98hc. R8H283 did not react with monomers of CD98hc; instead, it bound CD98hc in heterodimers with a CD98 light chain (CD98lc), a complex that functions as an amino acid transporter. CD98 heterodimers were abundant on MM cells and took up amino acids for constitutive production of immunoglobulin. Although CD98 heterodimers were also present on normal leukocytes, R8H283 did not react with them. The glycoforms of CD98hc present on normal leukocytes were distinct from those present on MM cells, which may explain the lack of R8H283 reactivity to normal leukocytes. R8H283 exerted anti-MM effects without damaging normal hematopoietic cells. These findings suggested that R8H283 is a candidate for mAb-based therapies for MM. In addition, our findings showed that a cancer-specific conformational epitope in a ubiquitous protein, which cannot be identified by transcriptome or proteome analyses, can be found by extensive screening of primary human tumor samples.


Subject(s)
Antibodies, Monoclonal , Multiple Myeloma , Antibodies, Monoclonal/therapeutic use , Humans
16.
Gan To Kagaku Ryoho ; 48(12): 1511-1513, 2021 Dec.
Article in Japanese | MEDLINE | ID: mdl-34911921

ABSTRACT

We report the case of an 84-year-old man who developed primary diffuse large B-cell lymphoma of the testes during the course of mycosis fungoides treated with topical medication. He was referred to our hospital due to bilateral testicular masses, and bilateral high orchiectomy was performed. A pathological diagnosis of diffuse large B-cell lymphoma was made after an examination of the surgical specimen. Rituximab-combined miniCHOP chemotherapy with prophylactic intrathecal injection resulted in complete remission without recurrence 1 year after diagnosis. People with mycosis fungoides are known to be at a higher risk of secondary malignancies than healthy individuals; hence, a pathological examination is important to confirm the diagnosis.


Subject(s)
Lymphoma, Large B-Cell, Diffuse , Mycosis Fungoides , Skin Neoplasms , Aged, 80 and over , Humans , Lymphoma, Large B-Cell, Diffuse/drug therapy , Male , Mycosis Fungoides/drug therapy , Rituximab , Skin Neoplasms/drug therapy , Testis
17.
Am J Blood Res ; 11(1): 66-71, 2021.
Article in English | MEDLINE | ID: mdl-33796391

ABSTRACT

Although isolated trisomy 9, a form of chromosome aneuploidy, is rare in acute myeloid leukemia (AML), up to 30 cases of AML involving isolated trisomy 9 have been reported to date. We report the case of a 77-year-old female with AML, in which trisomy 9 was detected as an isolated aberration. In addition, the patient's bone marrow displayed so-called sea-blue histiocytosis. The accumulation of further cases of isolated trisomy 9-harboring AML involving sea-blue histiocytosis is necessary to determine whether the coexistence of these findings is pathognomonic or a coincidence.

18.
Gan To Kagaku Ryoho ; 46(12): 1903-1905, 2019 Dec.
Article in Japanese | MEDLINE | ID: mdl-31879413

ABSTRACT

We report the case ofa 76-year-old man who had bacteremia due to Edwardsiella tarda during the course ofchemotherapy, including ponatinib, for the treatment of recurrent Philadelphia-positive acute lymphoblastic leukemia. Treatment with cefepime improved his general condition. The number ofreported cases ofbacteremia due to Edwardsiella tarda is limited. Further accumulation ofcases is necessary to obtain accurate data such as the risk factors of Edwardsiella tarda bacteremia.


Subject(s)
Bacteremia , Enterobacteriaceae Infections , Precursor Cell Lymphoblastic Leukemia-Lymphoma , Acute Disease , Aged , Edwardsiella tarda , Humans , Male
20.
Am J Blood Res ; 8(3): 17-20, 2018.
Article in English | MEDLINE | ID: mdl-30498621

ABSTRACT

Whole-arm translocations are relatively rare among hematological malignancies. There are a few reports on myeloid malignancies harboring der(1;21)(q10;q10). A 65-year-old male was referred to our hospital due to squamous cell carcinoma of the lung. Pembrolizumab monotherapy resulted in progression, and so chemotherapy involving nab-paclitaxel and carboplatin was administered thereafter. The patient developed cytopenia, and his bone marrow exhibited dysplasia. Chromosomal analysis revealed a whole-arm translocation, der(1;21)(q10;q10). Thus, the patient was diagnosed with myelodysplastic syndrome. The der(1;21)(q10;q10) translocation is a rare variant of the der(1;7)(q10;p10) translocation, which is an adverse prognostic factor for myeloid neoplasms. Clarifying the clinical features of myeloid neoplasms in patients with der(1;21)(q10;q10) would facilitate the elucidation of their tumorigenic mechanisms.

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