Subject(s)
Acanthamoeba/isolation & purification , Amebiasis/diagnosis , Central Nervous System Parasitic Infections/parasitology , Fever/parasitology , HIV Infections/complications , Headache/parasitology , Amebiasis/diagnostic imaging , Amebiasis/parasitology , Brain/diagnostic imaging , Central Nervous System Parasitic Infections/diagnostic imaging , Child , Diagnosis, Differential , Female , HIV Infections/diagnosis , Humans , Tomography, X-Ray ComputedABSTRACT
Eastern equine encephalitis virus infection is a rare sporadic central nervous system infection transmitted by a mosquito vector. Hemophagocytic lymphohistiocytosis (HLH) is a rare life-threatening disease associated with the inability of an overactive immune system to effectively respond to infections. Many viruses are known to trigger primary, as well as secondary, HLH. We report a pediatric case of eastern equine encephalitis virus-associated HLH which caused severe neurologic injury and death.
Subject(s)
Encephalomyelitis, Eastern Equine/diagnosis , Lymphohistiocytosis, Hemophagocytic/diagnosis , Encephalitis Virus, Eastern Equine/isolation & purification , Encephalomyelitis, Eastern Equine/complications , Enzyme-Linked Immunosorbent Assay , Fatal Outcome , Humans , Immunosuppressive Agents/therapeutic use , Infant , Lymphohistiocytosis, Hemophagocytic/complications , Lymphohistiocytosis, Hemophagocytic/drug therapy , MaleSubject(s)
Candidiasis/complications , Granulomatous Disease, Chronic/microbiology , Antifungal Agents/therapeutic use , Candidiasis/diagnosis , Candidiasis/drug therapy , Child, Preschool , Granulomatous Disease, Chronic/diagnosis , Granulomatous Disease, Chronic/drug therapy , Humans , Male , Tomography, Emission-Computed , Tomography, X-Ray ComputedABSTRACT
Many phenotypic manifestations have been reported in cardiofaciocutaneous (CFC) syndrome, but none, to date, are pathognomonic or obligatory. Previous histopathological studies reported findings in skin and hair; no autopsy studies have been published. We report the clinical and autopsy findings of a 7-year-old boy with severe CFC syndrome and malnutrition of psychosocial origin. Manifestations of CFC, reported previously, included macrocephaly and macrosomia at birth; short stature; hypotonia; global developmental delays; dry, sparse thin curly hair; sparse eyebrows and eyelashes; dilated cerebral ventricles; high cranial vault; bitemporal constriction; supraorbital ridge hypoplasia; hypertelorism; ptosis; exophthalmos; depressed nasal bridge; anteverted nostrils; low-set, posteriorly-rotated, large, thick ears; decayed, dysplastic teeth; strabismus; hyperelastic skin; wrinkled palms; keratosis pilaris atrophicans faciei; ulerythema ophryogenes; hyperkeratosis; gastroesophageal reflux; and tracheobronchomalacia. Additional findings, not previously reported, include islet cell hyperplasia, lymphoid depletion, thymic atrophy and congenital hypertrophy of peripheral nerves with onion bulb formations. Although the islet cell hyperplasia, lymphoid depletion, and thymic atrophy are nonspecific findings that may be associated with either CFC or malnutrition, the onion bulb hypertrophy is specific for a demyelinating-remyelinating neuropathy. These findings implicate congenital peripheral neuropathy in the pathogenesis of the developmental delays, feeding difficulties, respiratory difficulties, ptosis and short stature in this case. Additional studies of other cases of CFC are needed.
Subject(s)
Abnormalities, Multiple/pathology , Child Nutrition Disorders/pathology , Face/abnormalities , Heart Defects, Congenital/pathology , Peripheral Nervous System Diseases/pathology , Skin Abnormalities , Abnormalities, Multiple/genetics , Autopsy , Child , Fatal Outcome , Humans , Karyotyping , Male , Peripheral Nervous System Diseases/congenital , SyndromeSubject(s)
Cat-Scratch Disease/diagnosis , Ear Canal , Foreign Bodies/diagnosis , Mesothelioma, Cystic/diagnosis , Peritoneal Neoplasms/diagnosis , Arthralgia/etiology , Cat-Scratch Disease/complications , Cat-Scratch Disease/drug therapy , Child , Female , Foreign Bodies/therapy , Hip Joint , Humans , Immunocompromised Host , Magnetic Resonance Spectroscopy , Male , Tomography, X-Ray ComputedSubject(s)
Abscess/microbiology , Fusobacterium Infections/microbiology , Fusobacterium necrophorum , Mediastinal Diseases/microbiology , Thoracic Wall , Abscess/diagnosis , Child , Diagnosis, Differential , Female , Fusobacterium Infections/diagnosis , Humans , Mediastinal Diseases/diagnosis , Radiography , Thoracic Wall/diagnostic imagingSubject(s)
Penicillium , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/microbiology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/microbiology , Tomography, X-Ray Computed , Adolescent , Biopsy, Needle , Humans , Liver Abscess/diagnosis , Liver Abscess/microbiology , Liver Abscess/pathology , Male , Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology , Spleen/diagnostic imaging , Spleen/pathologyABSTRACT
A previously healthy 4-year old male, born in India and residing in Mobile, Alabama since October 1996 came to the emergency department in April 1997 because of general malaise, fever and vomits of 5 days duration. A peripheral smear of the complete blood count revealed the presence of malarial parasites within the erythrocytes. Plasmodium vivax was later identified in serial thin peripheral smears. He defervesced after initial treatment with oral quinine and pyrimethamine-sulfadoxine, followed by primaquine for 14 days.
