ABSTRACT
Desde que en el año 2006 Perrinaud describiera por primera vez 3 pacientes con ampollas hemorrágicas en relación con el uso de heparinas, han sido numerosos los casos publicados hasta la fecha, pasando en pocos años a constituir un proceso patológico claramente definido. Hacemos una revisión de todos los casos reportados, repasamos las claves diagnósticas y aquellas características que las diferencian de otras manifestaciones cutáneas provocadas por heparinas, cuyo pronóstico es más grave y su identificación resulta crucial (AU)
Since Perrinaud in 2006 first described three patients with hemorrhagic bullae in relation to the use of heparins, numerous cases have been published. Currently, this entity has been established as a clearly defined pathology. We review all reported cases, diagnostic features and features that differentiate it from other skin manifestations caused by heparin having a worse prognosis and requiring a precise identification (AU)
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Aged , Heparin/adverse effects , Skin Diseases/physiopathology , Necrosis , Risk Factors , Diagnosis, Differential , Vasculitis/diagnosis , Thrombosis/diagnosis , Heparin/therapeutic useABSTRACT
Since Perrinaud in 2006 first described three patients with hemorrhagic bullae in relation to the use of heparins, numerous cases have been published. Currently, this entity has been established as a clearly defined pathology. We review all reported cases, diagnostic features and features that differentiate it from other skin manifestations caused by heparin having a worse prognosis and requiring a precise identification.
