Subject(s)
Humans , Male , Middle Aged , /drug therapy , Omalizumab/therapeutic use , Anti-Allergic Agents/therapeutic use , Treatment OutcomeABSTRACT
BACKGROUND: Although the Spanish Ministry of Health prepares national therapeutic positioning reports (TPRs) and drug reimbursement policies, each of the country's 17 autonomous communities (ACs) is responsible for health care services and prescription requirements in its territory. The aim of the EQUIDAD study was to describe and explore potential differences in prescription requirements for new dermatology drugs across the autonomous communities. MATERIAL AND METHODS: Cross-sectional study conducted in April and May, 2023. Two dermatologists with management responsibilities from each autonomous community reported on territorial and more local prescription requirements for drugs covered by national TPRs issued between 2016 and 2022. RESULTS: Thirty-three researchers from 17 autonomous communities participated. The data submitted revealed between-community inequities in access to new drugs. Overall, 64.7% of the regions imposed additional prescription requirements to those mentioned in the TPRs for psoriasis. This percentage was lower for atopic dermatitis (35.3%) and melanoma (11.8%). The most common requirement for accessing a new drug was a previous prescription for another drug. Differences and additional requirements were also detected at the local level (i.e., differences between hospitals within the same autonomous community). CONCLUSIONS: Spain's autonomous communities have multiple regional and local prescription requirements that are not aligned with national TPR recommendations. These differences result in inequitable access to new drugs for both patients and practitioners across Spain.
Subject(s)
Dermatology , Humans , Spain , Cross-Sectional StudiesABSTRACT
BACKGROUND: Although the Spanish Ministry of Health prepares national therapeutic positioning reports (TPRs) and drug reimbursement policies, each of the country's 17 autonomous communities (ACs) is responsible for health care services and prescription requirements in its territory. The aim of the EQUIDAD study was to describe and explore potential differences in prescription requirements for new dermatology drugs across the autonomous communities. MATERIAL AND METHODS: Cross-sectional study conducted in April and May, 2023. Two dermatologists with management responsibilities from each autonomous community reported on territorial and more local prescription requirements for drugs covered by national TPRs issued between 2016 and 2022. RESULTS: Thirty-three researchers from 17 autonomous communities participated. The data submitted revealed between-community inequities in access to new drugs. Overall, 64.7% of the regions imposed additional prescription requirements to those mentioned in the TPRs for psoriasis. This percentage was lower for atopic dermatitis (35.3%) and melanoma (11.8%). The most common requirement for accessing a new drug was a previous prescription for another drug. Differences and additional requirements were also detected at the local level (i.e., differences between hospitals within the same autonomous community). CONCLUSIONS: Spain's autonomous communities have multiple regional and local prescription requirements that are not aligned with national TPR recommendations. These differences result in inequitable access to new drugs for both patients and practitioners across Spain.
Subject(s)
Dermatology , Humans , Spain , Cross-Sectional StudiesABSTRACT
Oculocutaneous albinism is a genetically heterogeneous, autosomal recessive group of disorders characterized by a generalized decreased or absence of melanin pigment in the eyes, hair, and skin. These patients have a greater sensitivity to UV radiation and a predisposition to skin tumors, mainly squamous cell carcinoma and basal cell carcinomas, and to a lesser extent malignant melanomas. Melanoma can be one of the most challenging cancers to diagnose in patients with albinism. We report an uncommon clinical presentation of melanoma, an amelanotic melanoma in the right supraciliar region in a patient with oculocutaneous albinism. The clinical presentation was an erythematous, scaly and ill-defined plaque. The skin biopsy revealed a lentigo maligna melanoma. Amelanotic melanomas are one of the two most difficult to diagnose subtypes of melanoma, together with the nevoid type. Melanoma in oculocutaneous albinism patients are often amelanotic, which makes their clinical diagnosis very difficult. These patients should be examined in the dermatology department at least once a year and it is recommended to have a high index of suspicion.
Subject(s)
Albinism, Oculocutaneous/complications , Melanoma, Amelanotic/pathology , Skin Neoplasms/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Dermoscopy , Female , Humans , Infant , Male , Melanoma, Amelanotic/complications , Melanoma, Amelanotic/diagnosis , Middle Aged , Skin Neoplasms/complications , Skin Neoplasms/diagnosisABSTRACT
Palisaded encapsulated neuroma is a rare, benign neural tumor. The involvement of the glans penis is rare; few cases have been reported. We present a 52-year-old man with a five-month course of a solitary painless lesion of the glans penis. Full excision of the nodule was performed. Histopathological and immunohistochemical analyses and examination was consistent with a palisaded encapsulated neuroma. We describe one of a few existing cases of this kind of tumor in the glans penis.
Subject(s)
Neuroma/pathology , Penile Neoplasms/pathology , Penis/pathology , Diagnosis, Differential , Humans , Male , Middle Aged , Neuroma/diagnosis , Penile Neoplasms/diagnosisABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Melanoma/diagnosis , Skin Neoplasms/diagnosis , Neoplasm Metastasis/pathology , Disease ProgressionABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Breast Neoplasms, Male/pathology , Carcinoma, Ductal, Breast/pathology , Diagnosis, Differential , Melanoma/pathologySubject(s)
Breast Neoplasms, Male/diagnosis , Carcinoma, Ductal, Breast/diagnosis , Melanoma/diagnosis , Skin Neoplasms/diagnosis , Aged , Breast Neoplasms, Male/pathology , Carcinoma, Basal Cell/diagnosis , Carcinoma, Ductal, Breast/pathology , Dermoscopy , Diagnosis, Differential , Humans , Male , Nipples/pathology , Skin Neoplasms/pathologyABSTRACT
Las lesiones blanquecinas de la mucosa oral se suelen diagnosticar de candidiasis, liquen plano o displasias; sin embargo, hay que tener en cuenta otras entidades que aunque infrecuentes cursan con leucoplasia. Se comunica el caso de una niña de 7 años con lesiones blanquecinas en la mucosa oral, que tras estudios analíticos, micológicos e histopatológicos, fue diagnosticada de nevus blanco esponjoso oral (AU)
Subject(s)
Child , Female , Humans , Mouth Mucosa , Nevus , Diagnosis, Differential , Mouth Neoplasms , Leukoplakia, OralABSTRACT
Whitish lesions in oral mucosa are usually diagnosed as candidosis, lichen planus or dysplasias. However, other infrequent entities associated with leukoplakia should be borne in mind. We present the case of a 7-year-old girl with whitish lesions in the oral mucosa. Laboratory, mycological and histopathological investigations were performed and the patient was diagnosed with oral white sponge nevus.
Subject(s)
Leukoplakia, Oral/diagnosis , Mouth Neoplasms/diagnosis , Nevus/diagnosis , Child , Diagnosis, Differential , Female , Humans , Mouth MucosaABSTRACT
BACKGROUND: Selective depletion of CD4+ T lymphocytes is common in both primary and secondary immunodeficiencies. Idiopathic CD4+ T lymphocytopenia (ICL) cases are defined as a persistent CD4+ T lymphocyte count of less than 300x10(6) cells/L and/or less than 20% of the total T-cell count. METHOD: A 40-year-old woman, with a history of psoriasis and paracetamol allergy, presented with persistent warts of the hands and condylomas of the ano-genitalia. Histological and virological analysis was carried out on genital and cutaneous lesions and peripheral blood. RESULTS: Serology for HIV-1, HIV-2, Epstein-Barr virus and parvovirus B19 were negative. There was lymphopenia of 10% CD4+ cells, with normal numbers of total leukocytes; there were no other-abnormal immunological findings. DNA analysis of cutaneous lesions revealed HPV-49 and HPV-3 in the hands and HPV-6 in the genital region. CONCLUSIONS: The cause of the ICL in this patient is unknown. HPV is not known to be an immunosuppressive agent; it remains to be determined whether the HPV-associated lesions are the cause or the result of immunosuppression.