ABSTRACT
BACKGROUND: Malnutrition is a frequent condition in the elderly, and is associated with prolonged hospitalization and increased mortality. However, the impacts of malnutrition among elderly patients with acute myocardial infarction have not been clarified yet. METHODS AND RESULTS: We enrolled 174 patients aged 65 years and over, admitted with the diagnosis of acute myocardial infarction (AMI), who underwent evaluation of nutritional status by Mini Nutritional Assessment (MNA) and evaluation of mortality risk by GRACE Score 2.0. All-cause mortality was the outcome considered for this study. Over a mean follow-up of 24.5 ± 18.2 months, 43 deaths have been registered (24.3%). Non-survivors were more likely to be older, with worse glomerular filtration rate, lower systolic blood pressure, lower albumin and MNA score, higher prevalence of Killip classification III-IV grade, and higher Troponin I levels. Multivariate Cox proportional analysis revealed that GRACE Score and MNA showed a significant and independent impact on mortality, (HR = 1.76, 95%, CI = 1.34â»2.32, and HR = 0.56, 95% CI = 0.42â»0.73, respectively). Moreover, the clinical decision curve revealed a higher clinical net benefit when the MNA was included, compared to the partial models without MNA. CONCLUSION: Nutritional status is an independent predictor of long-term mortality among elderly patients with AMI. MNA score in elderly patients with AMI may help prognostic stratification and identification of patients with, or at risk of, malnutrition in order to apply interventions to improve nutritional status, and maybe survival in this population.
Subject(s)
Malnutrition/complications , Myocardial Infarction/mortality , Aged , Aged, 80 and over , Female , Geriatric Assessment , Humans , Male , Nutrition Assessment , Nutritional Status , Risk FactorsABSTRACT
Despite recent advances in Pulmonary Arterial Hypertension (PAH) treatment, this condition is still characterized by an extremely poor prognosis. In this review, we discuss the use of newly-approved drugs for PAH treatment with already known mechanisms of action (macitentan), innovative targets (riociguat and selexipag), and novel therapeutic approaches with initial up-front combination therapy. Secondly, we describe new potential signaling pathways and investigational drugs with promising role in the treatment of PAH.
Subject(s)
Hypertension, Pulmonary/therapy , Signal Transduction/drug effects , Animals , Endothelin Receptor Antagonists/pharmacology , Genetic Therapy , Humans , Hypertension, Pulmonary/drug therapy , Immunotherapy , Phosphodiesterase 5 Inhibitors/pharmacologyABSTRACT
OBJECTIVES: To assess pressure injury (PI) incidence among patients hospitalized for acute myocardial infarction (AMI) in an intensive coronary care unit (ICCU) and to detect the impact of specific risk factors on the development of PI in this clinical setting. PATIENTS AND METHODS: Prospective cohort study in ICCU setting. Patients admitted for AMI: patients mean age 67.5±11.5 years (n=165). Norton Scale, Mini Nutritional Assessment (MNA), demographic, clinical and biochemical data collected at the time of ICCU admission have been tested in a logistic model to assess the odds ratios (ORs) of PI risk development. The jackknifed area under the receiver operating characteristic curve (AUC) and the decision curve analysis have been employed to assess the additive predictive value of a factor. RESULTS: Twenty-seven (16.3%) patients developed PIs. An increased PI risk was associated with advanced age (OR =2.5 every 10-year increase; 95% CI =1.1-5.7), while probability of PI development was reduced in patients with higher left ventricular ejection fraction (LVEF) (OR =0.4 every 5% increase; 95% CI =0.24-0.66), MNA score (OR =0.65 every unit change; 95% CI =0.44-0.95) and Norton Scale score (OR =0.7 every unit change; 95% CI =0.57-0.88). The AUC and the decision curve analysis showed that LVEF inclusion improved the discrimination power and the clinical net benefit of the final model. CONCLUSION: Age, LVEF, Norton Scale and MNA scores have a strong and independent clinical value as predictors of in-hospital PI development in patients with AMI. This finding has the potential to improve the clinical management of patients admitted in ICCU.
Subject(s)
Intensive Care Units/statistics & numerical data , Myocardial Infarction/complications , Myocardial Infarction/epidemiology , Pressure Ulcer/epidemiology , Acute Disease , Age Factors , Aged , Aged, 80 and over , Female , Humans , Incidence , Logistic Models , Male , Middle Aged , Nutrition Assessment , Odds Ratio , Prospective Studies , ROC Curve , Risk Factors , Ventricular Function, LeftABSTRACT
With the diagnosis of celiac disease rising in the past decade and with increased public awareness, team physicians are faced with both managing and diagnosing athletes with celiac disease. Sports medicine physicians need to recognize that celiac disease can present with a number of different symptoms and, therefore, should consider celiac disease as part of their differential in evaluating athletes with prolonged unexplained illnesses. Sports medicine physicians must be familiar with the appropriate laboratory tests and diagnostic procedures used to establish the diagnosis of celiac disease. A multidisciplinary approach in helping the newly diagnosed athlete with celiac disease is important to the successful treatment of the disease. Athletes with celiac disease often have problems with iron absorption (leading to anemia) and/or vitamin D and calcium absorption (leading to osteoporosis and poor bone health). Even athletes with known and long-standing celiac disease need additional care and supervision in ensuring there is no disruption in their gluten-free diet, which can lead to a flare-up of symptoms or a decrease in performance.
