1.
Adv Exp Med Biol
; 944: 47-52, 2017.
Article
in English
| MEDLINE
| ID: mdl-27826884
ABSTRACT
Antibiotics directly inhibit the growth and kill microorganisms, and many of them have immunomodulatory properties. We investigated the influence of cefotaxime and gentamicin on the release of neutrophil extracellular traps (NETs) - recently described strategy employed by neutrophils to fight infections. We found that gentamicin inhibits NETs release by human neutrophils, while cefotaxime did not have any impact on this process. The information that antibiotics can modulate NETs release, can be useful in the therapy of infectious diseases in patients suffering from NET-related diseases.
Subject(s)
Anti-Bacterial Agents/pharmacology , Extracellular Traps/drug effects , Neutrophils/drug effects , Cefotaxime/pharmacology , Gentamicins/pharmacology , Humans , Immunologic Factors/pharmacology , Neutrophil Activation/drug effects
2.
Blood Cancer J
; 6: e377, 2016 Jan 08.
Article
in English
| MEDLINE
| ID: mdl-26745851
Subject(s)
Antineoplastic Combined Chemotherapy Protocols/pharmacology , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Benzamides/administration & dosage , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy , Leukemia, Myelogenous, Chronic, BCR-ABL Positive/pathology , Neoplastic Stem Cells/drug effects , PPAR gamma/agonists , Piperazines/administration & dosage , Pyrimidines/administration & dosage , Thiazolidinediones/administration & dosage , Humans
3.
Int J Lab Hematol
; 37(5): e141-4, 2015 Oct.
Article
in English
| MEDLINE
| ID: mdl-26074132
