ABSTRACT
The authors analyze the findings of histologic and electron-microscopic examinations of skin biopsy specimens from 15 patients with xerotic balanoposthitis. The results evidence that xerotic balanoposthitis morphologically is characterized by atrophy of the epidermis, vacuolar dystrophy of the basal cells, changed structure of keratohyalin granules, presence of a vast edematous area under the epidermis, absence of elastic fibers, inflammatory cellular infiltrate under the edematous area. During initial manifestations of the disease and its progressive stage more manifest changes are detectable in the derma. Atrophy of the epidermis was not observed, a lesser edematous area was seen under the epidermis, and, in contrast to the typical pattern of sclerotic and atrophic lichen, a dense, more superficially located cellular infiltrate in the derma. Small-granular substance is detectable in the edematous area under the epidermis, as are numbers of microfibrils and this diffusely located collagen fibrils that indicate synthesis of fibrillar substances.
Subject(s)
Balanitis/pathology , Ichthyosis/pathology , Penis/pathology , Skin/pathology , Balanitis/metabolism , Biopsy , Histocytochemistry , Humans , Ichthyosis/metabolism , Male , Microscopy, Electron , Penis/metabolism , Skin/metabolismABSTRACT
Presents a detailed clinical description of two forms of xerotic obliterating balanoposthitis. Suggests a working classification of the condition, analyzes morphologic findings, proposes a new approach to therapy: laser photochemotherapy.
Subject(s)
Balanitis/diagnosis , Ichthyosis/diagnosis , Laser Therapy , Photochemotherapy/methods , Adult , Aged , Balanitis/drug therapy , Balanitis/pathology , Biopsy , Chronic Disease , Diagnosis, Differential , Humans , Ichthyosis/drug therapy , Ichthyosis/pathology , Male , Middle Aged , Penis/pathology , Skin/pathologyABSTRACT
A drastic increase (by 30.6 times) vs. the norm) of kallikrein activity was revealed in 70 patients with true eczema during exacerbation; blood plasma amidase activity was elevated 4.4-fold, serum alpha 2 macroglobulin antiprotease activity 1.4-fold. Laser photophoresis combined with application of a new Soviet nonsteroid anti-inflammatory agent orthofen reduced the parameters of the kallikrein-kinin system, and a tendency to their normalization could be observed.
Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/administration & dosage , Diclofenac/administration & dosage , Eczema/drug therapy , Iontophoresis/methods , Kallikrein-Kinin System/drug effects , Laser Therapy , Adult , Aged , Chronic Disease , Drug Evaluation , Eczema/blood , Female , Humans , Kallikrein-Kinin System/radiation effects , Male , Middle Aged , Remission InductionABSTRACT
A rationale is given for the use of a new physiotherapeutic method for the treatment of dermatologic patients: laser photophoresis. Experiments have demonstrated a better diffusion of the drug during photophoresis than through semipermeable membranes. The method has been employed in therapy of 27 patients with chronic eczemas with ortafen, a new Soviet anti-inflammatory nonsteroid drug.
