ABSTRACT
Administration of phenibut (0.25 g) during 4 weeks as a means of rehabilitation promoted optimization of the biochemical status and cerebral blood circulation in swimmers with various types of systemic hemodynamics, which were examined 20 minutes after warm-up.
Subject(s)
Cerebrovascular Circulation/drug effects , GABA Agonists/administration & dosage , General Adaptation Syndrome/physiopathology , Hemodynamics/drug effects , Swimming , gamma-Aminobutyric Acid/analogs & derivatives , Athletes , Child , General Adaptation Syndrome/rehabilitation , Humans , Male , gamma-Aminobutyric Acid/administration & dosageABSTRACT
The administration of aminalon (0.25 g), fenibut (0.25 g) and picamilon (0.10 g) during 4 weeks as a means of recovery for swimmers with disadaptation syndrome helped to optimize the biochemical status and cerebral circulation 20-min after warm-up. The reaction to the warm-up load under test conditions was characterized by increasing total blood filling of the brain and difficulty of venous outflow. Under the action of drugs, a decrease in blood filling of the brain and increase in venous blood outflow from the cerebral basin was observed 20 min after load in all test groups (except the hypokinetic group taking picamilon).
Subject(s)
Antioxidants/administration & dosage , Cerebrovascular Circulation/drug effects , GABA Agents/administration & dosage , Swimming , gamma-Aminobutyric Acid/analogs & derivatives , gamma-Aminobutyric Acid/administration & dosage , Child , Humans , Male , SyndromeSubject(s)
Life Style , Public Health , Adolescent , Adult , Age Factors , Alcohol Drinking/adverse effects , Child , Diet , Exercise , Female , Humans , Leisure Activities , Male , Risk Factors , Russia , Sex Factors , Smoking/adverse effects , Sports , Surveys and Questionnaires , Urban PopulationABSTRACT
The objective was to investigate the stimulating and normalizing effect of the adaptogen Rhodiola rosea extract SHR-5 in foreign students during a stressful examination period. The study was performed as a double-blind, randomized and placebo-controlled with low repeated dose regime. The study drug and the placebo were taken for 20 days by the students during an examination period. The physical and mental performance were assessed before and after the period, based on objective as well as on subjective evaluation. The most significant improvement in the SHR-5 group was seen in physical fitness, mental fatigue and neuro-motoric tests (p <0.01). The self-assessment of the general well-being was also significantly (p < 0.05) better in the verum group. No significance was seen in the correction of text tests or a neuro-muscular tapping test. The overall conclusion is that the study drug gave significant results compared to the placebo group but that the dose level probably was suboptimal.
Subject(s)
Fatigue/drug therapy , Phytotherapy , Plant Extracts/therapeutic use , Plants, Medicinal/therapeutic use , Stress, Psychological/physiopathology , Students, Medical , Adolescent , Adult , Double-Blind Method , Educational Measurement , Emotions , Fatigue/etiology , Humans , India/ethnology , Maze Learning/drug effects , Pilot Projects , Psychomotor Performance/drug effects , Pulse , SwedenABSTRACT
The effect of rhodaxon, an adaptogen preparation based on the Rhodiola rosea extract, upon the physical and intellectual working capacity and psychoemotional state of foreign students during their study in a Russian high school was evaluated. It was established that rhodaxon administration provided increase in the amount of veloergometric work accomplished and reliably increased the kinesthesiometric sensitivity. The drug also lead to marked increased in the general condition and a decrease in the level of psychic fatigue and situational anxiety. On the whole, the pharmacological properties of the rhodaxon preparation studied coincided with those reported for the gold root extract. The fact that the rhodaxon preparation contains no ethyl alcohol extends possibilities of the clinical administration of the new preparation.
