ABSTRACT
Food allergy is a condition with significant social and economic impact and a topic of intense concern for scientists and clinicians alike. Worldwide, over 220 million people suffer from some form of food allergy, but the number reported is just the tip of the iceberg. Recent years have brought new perspectives in diagnosing food allergy. Elucidating incriminated immunological mechanisms, along with drawing the clinical phenotype of food hypersensitivity reactions ensures an accurate diagnosis of food allergy. Moreover, molecular based allergy diagnosis, which is increasingly used in routine care, is a stepping-stone to improved management of food allergy patients. The aim of this review is to summarize the topic of IgE-mediated food allergy from the perspective of current diagnostic methods.
Subject(s)
Exanthema/diagnosis , Hypersensitivity/diagnosis , Mast Cells/immunology , Mastocytosis, Cutaneous/diagnosis , Mastocytosis, Systemic/diagnosis , Pruritus/diagnosis , Animals , Antigens, Dermatophagoides/immunology , Diagnosis, Differential , Exanthema/genetics , Humans , Hypersensitivity/genetics , Immunoglobulin E/blood , Male , Mastocytosis, Cutaneous/genetics , Mastocytosis, Systemic/genetics , Middle Aged , Oncogene Proteins, Fusion/genetics , Pruritus/genetics , Pyroglyphidae , Receptor, Platelet-Derived Growth Factor alpha/genetics , mRNA Cleavage and Polyadenylation Factors/geneticsABSTRACT
Worldwide, viral hepatitis chronic infections are a serious health problem and a very interesting topic for both clinicians and researchers. Viral hepatitis has a variety of clinical forms: mild, inactive or severe and with a slow evolution, whose architectural structure of the hepatic tissue evolves towards cirrhosis or hepatocellular carcinoma. Sometimes, the virally induced hepatic injury evolves spectacularly and rapidly leads to exitus. The factors that generate this evolution pattern depend on the immune response of the host and equally on the viral survival and immune surveillance avoidance strategies. This paper aims to resume new discoveries in the field of immunology of the B and C viral hepatitis infection, from the perspective of the complex interactions between virus and host.
