[Comparison of inactivated rabies vaccines obtained from diploid and polyploid heterologous cells (Hak, BHK, and Vero)]. / Etude comparative de vaccins rabiques inactivés obtenus à l'aide de cellules hétérologues diploides et polyploides (Hak, BHK et Véro).

Homologous or heterologous diploid or polyploid cells have been established as good producers of virus. In this study we present three types of experimental inactivated antirabies vaccines obtained under identical conditions from three types of cells. The study concerns the following characteristics of the vaccines: protecting powers, rabies antigens and major polypeptidic components; this study was performed on supernatants of tissue cultures and concentrated and purified vaccines. Moreover, some cellular and serum contaminants as well as minor rabies proteins were analysed in the viral solutions. It, thus, appears that all these types of vaccines have a similar protecting power (Number of 50% protective doses/micrograms viral protein).

Evaluation and comparative studies of inactivated rabies vaccines obtained in the heterologous diploid and polyploid cells (HAK, BHK and VERO).

This study is concerned with the following characteristics of the vaccines: 1.) protecting power, 2.) rabies antigens and 3.) major polypeptide components. This study was performed on supernatants of tissue cultures and on concentrated and purified vaccines. Moreover, some cellular and serum contaminants, especially the proteins produced by BHK cells, as well as minor rabies proteins, were analysed in the viral solutions. Thus, it appears that all three types of vaccines have a similar protecting power (Number of 50% protective doses/micrograms viral protein).