ABSTRACT
PURPOSE: To assess the effects of systemic propranolol on refractive error in infants with periocular capillary hemangiomas. METHODS: A single-center study of consecutive patients with capillary hemangiomas treated with systemic propranolol. Refractive data were analyzed using Long's matrix formalism and the methods of Harris and Kaye. RESULTS: Seventeen patients were included. At 6 months postoperatively, hemangioma size reduced from 3,214 to 1,806 mm(3) (standard deviation: 4,122 to 2,441). Mean refractive error in the affected eye significantly reduced: -1.25/0.38 × 36 (95% confidence intervals: -5.08/1.20 × 90 to 1.64/1.43 × 180, P = .048) with a smaller change (P = .06) in the unaffected eye of -1.01/+0.31 × 3.16 (95% confidence intervals: -4.02/+1.12 × 180 to +1.49/+0.51 × 90). CONCLUSIONS: Propranolol produced a clinically significant reduction in the infants' refractive error and anisometropia. The reduction in the total refractive error and anisometropia has not been evident in previous analyses, which have concentrated on the change in the "cylinder" as the principal outcome measure.
Subject(s)
Adrenergic beta-Antagonists/administration & dosage , Eye Neoplasms/drug therapy , Hemangioma, Capillary/drug therapy , Propranolol/administration & dosage , Refractive Errors/physiopathology , Astigmatism , Child, Preschool , Eye Neoplasms/physiopathology , Female , Hemangioma, Capillary/physiopathology , Humans , Male , Refraction, Ocular/physiology , Retrospective StudiesABSTRACT
We describe a 12-year-old boy in England with keratitis secondary to tarantula hairs embedded within the stroma of his cornea. Every attempt must be made to isolate these hairs at the first visit as they have a barbed nature and have a propensity to propagate through ocular tissues. A chronic keratitis requiring long-term steroid use may result if hairs persist in the cornea. Children who keep tarantulas as pets should be instructed on safe handling to prevent the tarantula from adopting defence mechanisms and shedding their hairs.
Subject(s)
Eye Foreign Bodies/complications , Hair , Keratitis/etiology , Pets , Animals , Child , Eye Foreign Bodies/therapy , Follow-Up Studies , Humans , Keratitis/physiopathology , Keratitis/therapy , Male , Risk Assessment , Spiders , Treatment OutcomeABSTRACT
Case series of four patients with CNVM secondary to PIC treated solely with anti VEGF in three cases and in combination with PDT in the other. This series reveals long term follow up (3 months to 28 months) which is currently not described in the literature.
Subject(s)
Angiogenesis Inhibitors/therapeutic use , Choroidal Neovascularization/drug therapy , Photochemotherapy , Vascular Endothelial Growth Factor A/antagonists & inhibitors , Adult , Antibodies, Monoclonal/therapeutic use , Antibodies, Monoclonal, Humanized , Choroid Diseases/complications , Choroid Diseases/physiopathology , Choroidal Neovascularization/etiology , Choroidal Neovascularization/physiopathology , Combined Modality Therapy , Female , Fluorescein Angiography , Humans , Intravitreal Injections , Male , Microscopy, Acoustic , Middle Aged , Ranibizumab , Tomography, Optical Coherence , Visual AcuityABSTRACT
We describe a report of a child with a horner's syndrome and sixth nerve paresis secondary to a petrous internal carotid artery (ICA) aneurysm. Management of this condition involved coiling of the aneurysm and the use of botulinum toxin to manage his strabismus and associated symptoms.
