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1.
Sci Rep ; 14(1): 2312, 2024 01 28.
Article in English | MEDLINE | ID: mdl-38282043

ABSTRACT

The European healthcare sector faces a significant shortage of healthcare workers. Assessing the prevalence of this issue and understanding its direct and indirect determinants are essential for formulating effective recruitment programs and enhancing job retention strategies for physicians and nurses. A multicentric cross-sectional study was conducted, involving 381 physicians and 1351 nurses recruited from eight European hospitals in Belgium, the Netherlands, Italy, and Poland. The study focused on assessing turnover intentions among healthcare workers based on the Job Demands-Resources model, using an online questionnaire. Structural equation models were employed to test the data collection questionnaires' construct validity and internal consistency. The turnover intention was assessed by agreement with the intention to leave either the hospital or the profession. Among physicians, 17% expressed an intention to leave the hospital, while 9% intended to leave the profession. For nurses, the figures were 8.9% and 13.6%, respectively. The internal consistency of the questionnaires exceeded 0.90 for both categories of health workers. Depersonalization and job dissatisfaction were identified as direct determinants of turnover intention, with work engagement being particularly relevant for nurses. We found a higher intention to leave the hospital among physicians, while nurses were more prone to leave their profession. To mitigate turnover intentions, it is recommended to focus on improving job satisfaction, work engagement and fostering a positive working climate, thereby addressing depersonalisation and promoting job retention.


Subject(s)
Nurses , Nursing Staff, Hospital , Physicians , Humans , Job Satisfaction , Cross-Sectional Studies , Intention , Depersonalization , Europe , Surveys and Questionnaires
2.
BMC Oral Health ; 23(1): 4, 2023 01 03.
Article in English | MEDLINE | ID: mdl-36597048

ABSTRACT

INTRODUCTION: Oral mucositis (OM) is a major side effect of cancer therapy, which is associated with significant symptoms, treatment delays and increased costs for the health system. It is an important component of the quality of life of cancer patients and, until now, there has been no gold standard regarding prevention or treatment of this pathology. Notwithstanding the paucity of treatment guidelines (due to limited evidence from high-quality, rigorous studies), sodium bicarbonate (SB) rinses are one of the most used agents for OM management. OBJECTIVES: A systematic review (2000-2022) was performed in order to compare and examine different agents versus sodium bicarbonate (SB) in preventing or treating OM. SOURCES: Eleven randomized controlled trials (RCT) were evaluated: four were conducted for the prevention and seven for the management of OM. The risk of bias of RCTs was assessed using the revised Cochrane risk of bias tool for randomized trials. STUDY SELECTION: According to the RoB2 evaluation for randomized trials, four RCTs were judged to be at a high risk of bias, two were rated as 'problematic', while five were deemed to be a low risk of bias. CONCLUSIONS: The results revealed that there was no evidence for supporting SB in OM treatment regarding management and prevention. CLINICAL SIGNIFICANCE: Results showed in this review takes on a strategic importance in the use of SB for OM management or prevention; indiscriminate use of SB could be counterproductive because it causes a sudden pH increase and it delays proper OM pharmacological treatment.


Subject(s)
Neoplasms , Stomatitis , Humans , Sodium Bicarbonate/therapeutic use , Stomatitis/drug therapy , Stomatitis/prevention & control , Neoplasms/complications
3.
Theriogenology ; 198: 12-18, 2023 Mar 01.
Article in English | MEDLINE | ID: mdl-36529107

ABSTRACT

To achieve optimal vitrification, tissue structure and fragment size represent a challenge for obtaining sufficient cooling velocity. Theoretically, thin ovarian tissue fragments lead to higher surface contact, hence higher solute penetration. Another critical factor is the concentration of cryoprotectants (CPA): CPA toxicity may occur with high concentrations, and as such, this may induce local apoptosis. Therefore two experiments were conducted: In experiment I, we compared the effect of sucrose supplementation in vitrification solution along with ovarian fragments of different sizes on post-warming tissue viability and follicle architecture. Fragments of two different sizes, with a thickness and radius of 1.5 × 0.75 mm and 3 × 1.5 mm respectively were vitrified in vitrification solution without sucrose and with 0.5 M sucrose supplementation. Post-warming, fragments of ovarian tissue (fresh and vitrified) were evaluated for viability (Calcein AM/Propidium Iodide) and for morphology (hematoxylin-eosin). In experiment II, we aimed to reduce cryoprotectant toxicity by using lower CPA concentrations in combination with an optimized carrier medium (HypThermosol®; HTS). Ovarian tissue fragments were randomly allocated to five groups (A: fresh controls; B: vitrified in GLOBAL® TOTAL® LP w/HEPES with 15% ethylene glycol (EG) and 15% DMSO; C: vitrified in HTS with 5% EG and 5% DMSO; D: vitrified in HTS with 10% EG and 10% DMSO; E: vitrified in HTS with 15% EG and 15% DMSO). Fragments (fresh and vitrified) were evaluated for morphology (hematoxylin-eosin) and for apoptosis through the activity of caspase-3. Results showed that follicular morphology was affected by the size of the fragment; smaller sized fragments contained a greater proportion of intact follicles (53.8 ± 2.0%) compared to the larger fragments (40.3 ± 2.0%). Our results demonstrated that 1.5 × 0.75 mm sized pieces vitrified in a vitrification solution supplemented with 0.5 M sucrose had more intact follicles (54.8 ± 1.3%; P = 0.0002) after vitrification. In addition, HTS presented no additional protective effect as a base medium, neither for follicular morphology nor apoptotic rate.


Subject(s)
Cryopreservation , Vitrification , Female , Cats , Animals , Cryopreservation/veterinary , Dimethyl Sulfoxide/pharmacology , Eosine Yellowish-(YS) , Hematoxylin , Cryoprotective Agents/pharmacology , Ethylene Glycol/pharmacology , Sucrose/pharmacology
4.
Vet J ; 264: 105538, 2020 Oct.
Article in English | MEDLINE | ID: mdl-33012439

ABSTRACT

Cellular adaptation to a hypoxic microenvironment is essential for tumour progression and is largely mediated by HIF-1α and hypoxia-regulated factors, including CXCR4, VEGF-A and GLUT-1. In human osteosarcoma, hypoxia is associated with resistance to chemotherapy as well as with metastasis and poor survival, whereas little is known about its role in canine osteosarcoma (cOSA). This study aimed primarily to evaluate the prognostic value of several known hypoxic markers in cOSA. Immunohistochemical analysis for HIF-1α, CXCR4, VEGF-A and GLUT-1 was performed on 56 appendicular OSA samples; correlations with clinicopathological features and outcome was investigated. The second aim was to investigate the in vitro regulation of markers under chemically induced hypoxia (CoCl2). Two primary canine osteosarcoma cell lines were selected, and Western blotting, immunofluorescence and qRT-PCR were used to study protein and gene expression. Dogs with high-grade OSA (35.7%) were more susceptible to the development of metastases (P = 0.047) and showed high HIF-1α protein expression (P = 0.007). Moreover, HIF-1α overexpression (56%) was correlated with a shorter disease-free interval (DFI; P = 0.01), indicating that it is a reliable negative prognostic marker. The in vitro experiments identified an accumulation of HIF-1α in cOSA cells after chemically induced hypoxia, leading to a significant increase in GLUT-1 transcript (P = 0.02). HIF-1α might be a promising prognostic marker, highlighting opportunities for the use of therapeutic strategies targeting the hypoxic microenvironment in cOSA. These results reinforce the role of the dog as a comparative animal model since similar hypoxic mechanisms are reported in human osteosarcoma.


Subject(s)
Bone Neoplasms/veterinary , Cell Hypoxia/physiology , Dog Diseases/physiopathology , Hypoxia-Inducible Factor 1, alpha Subunit/genetics , Hypoxia-Inducible Factor 1, alpha Subunit/physiology , Osteosarcoma/veterinary , Animals , Biomarkers, Tumor/analysis , Bone Neoplasms/chemistry , Bone Neoplasms/physiopathology , Cell Line, Tumor , Dog Diseases/pathology , Dogs , Female , Gene Expression Regulation, Neoplastic , Glucose Transporter Type 1/analysis , Hypoxia-Inducible Factor 1, alpha Subunit/analysis , Immunohistochemistry/veterinary , Male , Neoplasm Metastasis/physiopathology , Osteosarcoma/chemistry , Osteosarcoma/physiopathology , Prognosis , Receptors, CXCR4/analysis , Vascular Endothelial Growth Factor A/analysis
5.
Vet Pathol ; 54(3): 405-412, 2017 05.
Article in English | MEDLINE | ID: mdl-28438108

ABSTRACT

Canine osteosarcoma is highly resistant to current chemotherapy; thus, clarifying the mechanisms of tumor cell resistance to treatments is an urgent need. We tested the geldanamycin derivative 17-AAG (17-allylamino-17-demethoxygeldanamycin) prototype of Hsp90 (heat shock protein 90) inhibitors in 2 canine osteosarcoma cell lines, D22 and D17, derived from primary and metastatic tumors, respectively. With the aim to understand the interplay between cell death, autophagy, and mitophagy, in light of the dual effect of autophagy in regulating cancer cell viability and death, D22 and D17 cells were treated with different concentrations of 17-AAG (0.5 µM, 1 µM) for 24 and 48 hours. 17-AAG-induced apoptosis, necrosis, autophagy, and mitophagy were assessed by transmission electron microscopy, flow cytometry, and immunofluorescence. A simultaneous increase in apoptosis, autophagy, and mitophagy was observed only in the D22 cell line, while D17 cells showed low levels of apoptotic cell death. These results reveal differential cell response to drug-induced stress depending on tumor cell type. Therefore, pharmacological treatments based on proapoptotic chemotherapy in association with autophagy regulators would benefit from a predictive in vitro screening of the target cell type.


Subject(s)
Antineoplastic Agents/pharmacology , Benzoquinones/pharmacology , Bone Neoplasms/veterinary , Dog Diseases/pathology , Lactams, Macrocyclic/pharmacology , Osteosarcoma/veterinary , Animals , Antineoplastic Agents/therapeutic use , Apoptosis/drug effects , Autophagy/drug effects , Benzoquinones/therapeutic use , Bone Neoplasms/drug therapy , Bone Neoplasms/pathology , Cell Line, Tumor , Dog Diseases/drug therapy , Dogs , Dose-Response Relationship, Drug , Lactams, Macrocyclic/therapeutic use , Microscopy, Electron, Transmission/veterinary , Mitophagy/drug effects , Osteosarcoma/drug therapy , Osteosarcoma/pathology
6.
Vet Comp Oncol ; 15(2): 462-469, 2017 Jun.
Article in English | MEDLINE | ID: mdl-26833575

ABSTRACT

Canine malignant melanoma (CMM) is the most common canine oral tumour, and up to 70-75% of dogs in stage II-III die within 1 year after surgery. The purpose of this study was to evaluate the expression of platelet-derived growth factors receptors (PDGFR)-α and -ß in stage II and III CMMs and to correlate it with prognosis. PDGFRs expression was evaluated by immunohistochemistry on 48 cases of formalin-fixed CMM samples and correlated with clinical-pathological findings and outcome after surgery. PDGFRs co-expression was observed in 37.5% of cases. Positivity for PDGFR-α and -ß receptor was present in 54.2 and 47.9% of cases, respectively. Ki67 values >19.5% were ascertained in 66.7% of cases. Statistical analysis showed that PDGFRs co-expression and Ki67 values > 19.5% were both associated with worse prognosis. PDGFRs expression suggests a role in the pathogenesis and progression of CMM, and α and ß co-expression appears to be associated to worse prognosis.


Subject(s)
Dog Diseases/metabolism , Melanoma/veterinary , Mouth Neoplasms/veterinary , Receptors, Platelet-Derived Growth Factor/metabolism , Animals , Dog Diseases/diagnosis , Dog Diseases/mortality , Dogs , Female , Gene Expression Regulation, Neoplastic , Male , Melanoma/diagnosis , Melanoma/metabolism , Melanoma/mortality , Mouth Neoplasms/diagnosis , Mouth Neoplasms/metabolism , Mouth Neoplasms/mortality , Prognosis , Receptor, Platelet-Derived Growth Factor alpha/metabolism , Receptor, Platelet-Derived Growth Factor beta/metabolism , Survival Analysis
7.
Vet Comp Oncol ; 15(3): 996-1013, 2017 Sep.
Article in English | MEDLINE | ID: mdl-27146852

ABSTRACT

Reported post-surgery 1-year survival rate for oral canine malignant melanoma (cMM) is around 30%; novel treatments are needed as the role of adjuvant chemotherapy is unclear. This prospective study regards adjuvant electrovaccination with human chondroitin sulfate proteoglycan-4 (hCSPG4)-encoded plasmid in 23 dogs with resected II/III-staged CSPG4-positive oral cMM compared with 19 dogs with resected only II/III-staged CSPG4-positive oral cMM. Vaccination resulted in 6-, 12-, 18- and 24-month survival rate of 95.6, 73.9, 47.8 and 30.4%, respectively [median survival time (MST) 684 days, range 78-1694, 8 of 23 dogs alive] and 6-, 12-, 18- and 24-month disease-free interval (DFI) rate of 82.6, 47.8, 26.1 and 17.4%, respectively (DFI 477 days, range 50-1694). Non-vaccinated dogs showed 6-, 12-, 18- and 24-month survival rate of 63.2, 26.3, 15.8 and 5.3%, respectively (MST 200 days, range 75-1507, 1 of 19 dogs alive) and 6-, 12-, 18- and 24-month DFI rate of 52.6, 26.3, 10.5 and 5.3%, respectively (DFI 180 days, range 38-1250). Overall survival and DFI of vaccinated dogs was longer in those <20 kg. In vaccinated and non-vaccinated dogs local recurrence rate was 34.8 and 42%, respectively while lung metastatic rate was 39 and 79%, respectively.


Subject(s)
Chondroitin Sulfate Proteoglycans/immunology , Dog Diseases/therapy , Melanoma/veterinary , Mouth Neoplasms/veterinary , Adjuvants, Immunologic/therapeutic use , Animals , Cancer Vaccines/therapeutic use , Combined Modality Therapy , Dog Diseases/mortality , Dogs , Female , Male , Melanoma/mortality , Melanoma/therapy , Mouth Neoplasms/mortality , Mouth Neoplasms/therapy
8.
Vet J ; 197(2): 474-82, 2013 Aug.
Article in English | MEDLINE | ID: mdl-23583698

ABSTRACT

Mammary gland tumours, the most common malignant neoplasm in bitches, often display myoepithelial (ME) cell proliferation. The aim of this study was to isolate, purify, culture and characterise ME cells from normal and neoplastic canine mammary glands. Monodispersed cells from three normal canine mammary glands and five canine mammary tumours were incubated with an anti-Thy1 antibody and isolated by magnetic-activated cell sorting (MACS). Cells isolated from two normal glands (cell lines CmME-N1 and CmME-N2) and four tumours (cell lines CmME-K1 from a complex carcinoma, CmME-K2 from a simple tubulopapillary carcinoma, and CmME-K3 and CmME-K4 from two carcinomas within benign tumours) were cultured in supplemented DMEM/F12 media for 40days. Cell purity was >90%. Tumour-derived ME cell lines exhibited heterogeneous morphology, growth patterns and immunocytochemical expression of cytokeratins, whereas cell lines from normal glands retained their morphology and levels of cytokeratin expression during culture. Cell lines from normal glands and carcinomas within benign tumours grew more slowly than those from simple and complex carcinomas. This methodology has the potential to be used for in vitro analysis of the role of ME cells in the growth and progression of canine mammary tumours.


Subject(s)
Cell Culture Techniques/veterinary , Dog Diseases/pathology , Epithelial Cells/classification , Mammary Glands, Animal/cytology , Mammary Neoplasms, Animal/pathology , Myoepithelioma/veterinary , Animals , Dogs , Epithelial Cells/cytology , Epithelial Cells/physiology , Female , Gene Expression Regulation/physiology , Immunohistochemistry , Myoepithelioma/pathology , Thy-1 Antigens/genetics , Thy-1 Antigens/metabolism
9.
Vet J ; 191(1): 65-71, 2012 Jan.
Article in English | MEDLINE | ID: mdl-21282070

ABSTRACT

The PI3K/AKT/PTEN pathway is involved in the pathogenesis of several human cancers. This study investigated the biological and prognostic value of PI3K/AKT/PTEN pathway dysregulation in feline mammary tumours. Expression of p-AKT, HER2, PTEN and steroid receptors was assessed by immunohistochemistry (IHC) in 27 malignant and 12 benign mammary tumours from 39 female cats followed up over a 24-month period. Feline mammary carcinoma (FMC) cell lines were analyzed by Western blot and the feline AKT gene sequence was characterized. p-AKT expression statistically correlated with tumour malignancy, histological dedifferentiation and clinical recurrence. The animals with tumours expressing p-AKT had a shorter disease-free period than those with p-AKT-negative tumours. AKT activation was associated with HER2 expression and PTEN down-regulation, as occurs in human breast cancer, and feline AKT sequencing showed high homology with the human AKT gene. No AKT activation was observed in relation to either oestrogen receptor α (ERα) or progesterone receptor expression. Taken together, these data offer an explanation for AKT signalling and its role in FMC pathogenesis and prognosis, shedding new light on similarities between feline mammary tumours and hormone-independent breast cancer.


Subject(s)
Biomarkers, Tumor/metabolism , Cat Diseases/diagnosis , Mammary Neoplasms, Animal/diagnosis , Proto-Oncogene Proteins c-akt/metabolism , Animals , Biomarkers, Tumor/genetics , Cat Diseases/epidemiology , Cat Diseases/pathology , Cats , Cell Line, Tumor , Female , Immunohistochemistry/veterinary , Italy/epidemiology , Mammary Neoplasms, Animal/epidemiology , Mammary Neoplasms, Animal/pathology , Predictive Value of Tests , Prognosis , Proto-Oncogene Proteins c-akt/genetics , Receptor, ErbB-2/metabolism , Receptors, Estrogen/metabolism , Receptors, Progesterone/metabolism , Survival Analysis
10.
Vet Rec ; 167(8): 291-6, 2010 Aug 21.
Article in English | MEDLINE | ID: mdl-20729516

ABSTRACT

This study investigated progesterone receptor (PR) cDNA expression in the testes, prostate and bulbourethral glands of prepubertal calves treated experimentally with high and low doses of 17beta-oestradiol and with testosterone. Tissue samples were examined histologically and immunohistochemically for PR. Western blot analysis and quantitative PCR against PR was performed on cDNA and protein extracted from the same tissues. Bulbourethral glands from animals treated with low and high dosages of 17beta-oestradiol had 39- and 429-fold increases of PR transcript, respectively, compared with controls. In the prostate there were 7.5- and 16-fold increases, respectively. Animals treated with testosterone showed no increases in PR transcript. The results demonstrate that 17beta-oestradiol specifically induces marked overexpression of the PR gene and protein, particularly in the bulbourethral gland.


Subject(s)
Cattle/metabolism , Estradiol/pharmacology , Gene Expression Regulation/drug effects , Receptors, Progesterone/metabolism , Testosterone/pharmacology , Animals , Animals, Newborn , Biomarkers/metabolism , Bulbourethral Glands/metabolism , Cattle/physiology , DNA, Complementary/metabolism , Dose-Response Relationship, Drug , Gene Expression Regulation/physiology , Male , Prostate/metabolism , Random Allocation , Sexual Maturation , Testis/metabolism
11.
G Chir ; 23(10): 376-8, 2002 Oct.
Article in Italian | MEDLINE | ID: mdl-12611259

ABSTRACT

The Authors report their experience in the treatment of groin hernias. Over the years, hospital stay and anaesthetic procedure were modified without compromising the quality of results. The Authors conclude that groin hernia may be treated in a outpatient or day surgery regimen saving money.


Subject(s)
Hernia, Inguinal/surgery , Adult , Aged , Aged, 80 and over , Ambulatory Surgical Procedures , Costs and Cost Analysis , Female , Hernia, Inguinal/economics , Humans , Italy , Male , Middle Aged , Retrospective Studies
13.
Ann N Y Acad Sci ; 945: 132-7, 2001 Sep.
Article in English | MEDLINE | ID: mdl-11708466

ABSTRACT

An increased fetal DNA concentration in maternal plasma has been observed in placental pathological conditions associated with hypertension and preeclampsia. To confirm these data, we performed real-time quantitative PCR on the SRY gene in a group of physiological and pathological male-bearing pregnancies. In 78 physiological pregnancies, fetal DNA concentration in maternal plasma was 20.7, 13.4, 23.6, and 74.8 genome-equivalents (g.e.)/mL during the first, second, and third trimesters and at term, respectively. In 10 preeclamptic women, fetal DNA concentration ranged from 59.3 to 615.2 g.e./mL (median: 332.9). In 7 women with preeclampsia and IUGR (intrauterine growth retardation), fetal DNA ranged from 96.5 to 859 g.e./mL (median: 146.8). In 4 women with IUGR and hypertension, fetal DNA ranged from 34 to 473.5 g.e./mL (median: 142.4). In 3 patients with IUGR, fetal DNA ranged from 168.6 to 519.7 g.e./mL (median: 308.1). In 2 patients with IUGR and HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome, fetal DNA concentration ranged from 105 to 394.1 g.e./mL (median: 249.7). Four women who developed preeclampsia some weeks later showed fetal DNA levels within the physiological range. These data suggest that increased fetal DNA concentrations might represent a valuable marker of placental abnormalities and suggest that this rise may precede clinical manifestation of preeclampsia by only a few weeks.


Subject(s)
DNA/blood , Fetus/metabolism , Maternal-Fetal Exchange , Placenta/abnormalities , Base Sequence , DNA Primers , Female , Humans , Male , Pregnancy , Pregnancy Complications
14.
Minerva Chir ; 51(12): 1049-55, 1996 Dec.
Article in Italian | MEDLINE | ID: mdl-9064573

ABSTRACT

The authors report their experience of 21 cases of post-traumatic hernias of the diaphragm. On the basis of the results obtained by discussion of etiologic, diagnostic and therapeutic patterns they make at the conclusion that the high mortality, associated with diaphragmatic hernias, can be reduced only with a short time of diagnosis and a prompt surgical treatment of the associated lesions.


Subject(s)
Hernia, Diaphragmatic, Traumatic/surgery , Accidents, Occupational , Accidents, Traffic , Adult , Aged , Hernia, Diaphragmatic, Traumatic/diagnosis , Hernia, Diaphragmatic, Traumatic/etiology , Humans , Middle Aged , Time Factors , Wounds, Gunshot/complications
15.
Recenti Prog Med ; 85(11): 521-5, 1994 Nov.
Article in Italian | MEDLINE | ID: mdl-7855385

ABSTRACT

The objective of the study was to evaluate the significance of the determination of antithyroid antibodies in hyperthyroid patients. Two-hundred-fifteen untreated Graves' hyperthyroid patients (active toxic diffuse goiter-TDG), 54 Plummer's hyperthyroid patients (focal hyperthyroidism) and 46 subjects with other forms of hyperthyroidism were studied. Serum levels of T4, T3, TSH, TSH receptor antibody (TRAb), microsomal antibody (TMAb), and thyroglobulin antibody (TGAb) were evaluated before starting treatment, at regular intervals during therapy, and during the follow-up period after therapy was withdrawn. The antibodies were positive in all patients with active and non-active TGD but positive in only two patients (3.7%) with focal hyperthyroidism. During the treatment interval, TRAb, TMAb and TGAb serum levels fell with a nadir in the 7th month of therapy. In particular, TRAb fell to normal levels in all patients who had basal levels less than 500 U/l (97.7% of the cases) while TMAb and TGAb remained positive. Relapses, following the completion of therapy, occurred in 20.4% after one year and in 33% after two years. Relapses were always linked to a new increase in TRAb. In conclusion, TRAb can be useful in the determination of early disease and in diagnosing remission. It did not appear useful as a prognostic indicator for relapse in individual patients.


Subject(s)
Autoantibodies/blood , Hyperthyroidism/blood , Microsomes/immunology , Thyroglobulin/immunology , Thyroid Hormones/blood , Adult , Female , Follow-Up Studies , Humans , Hyperthyroidism/immunology , Male , Middle Aged
16.
Chir Ital ; 40(2): 126-33, 1988 Apr.
Article in Italian | MEDLINE | ID: mdl-3048730

ABSTRACT

The authors illustrate the cases of spontaneous pneumothorax observed in their institute along with the diagnostic and therapeutic aspects. In accord with the experience of others as reported in the literature, they stress the importance of a precise, immediate diagnosis for the purposes of adopting the treatment of choice: in the presence of closed, partial forms a conservative approach is to be preferred, whereas in open and/or hypertensive cases an aspirative thoracic drainage must be provided without delay. Aggressive surgical treatment, with resection of the bullous lesions responsible for bronchopleural fistulas, will resolve the condition and should be implemented after a reasonable waiting period with aspirative drainage, or even, electively, in the first instance, in the presence of multiple relapses. In any event, the authors stress the need to avoid uncertainty and delay in view of the youthful age of most of the subjects affected and the potential danger of the complications of this apparently banal disease.


Subject(s)
Pneumothorax/surgery , Age Factors , Drainage/methods , Female , Humans , Male , Pneumothorax/etiology
17.
Chir Ital ; 39(1): 3-16, 1987 Feb.
Article in Italian | MEDLINE | ID: mdl-3607979

ABSTRACT

The authors considered a series of 13 patients undergone surgical operation for primary malignant lymphoma of digestive system, with gastric, gastro-jejunal, jejunal, ileal and colic localization. They examined diagnostic and therapeutic features and the follow-up data. According to literature, the authors remark the importance of roentgenology and endoscopy, that together with bioptic data may reach a definite and early diagnosis; an elective and wide surgical exeresis seems useful in early stages, showing a better prognosis and epithelial malignancies. IV stage patients, however, had a very poor survival; a quick management appears today the only factor affecting long-term results in these patients.


Subject(s)
Gastrointestinal Neoplasms , Lymphoma/surgery , Adult , Aged , Female , Gastrointestinal Neoplasms/diagnostic imaging , Gastrointestinal Neoplasms/pathology , Gastrointestinal Neoplasms/surgery , Humans , Lymphoma/diagnostic imaging , Lymphoma/pathology , Male , Middle Aged , Radiography
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