1.
Chem Commun (Camb)
; 51(88): 15956-9, 2015 Nov 14.
Article
in English
| MEDLINE
| ID: mdl-26377508
ABSTRACT
In this report we present a polyketal, termed pADK, which has adamantane groups embedded in its backbone, and degrades into neutral excretable compounds. pADK was synthesized via click chemistry and had a MW of 49 472 and a PDI of 1.74. We demonstrate here that pADK can increase the transfection efficiency of CD1800 (PEI of 1800 modified ß-cyclodextrin) 60 fold, yet cause no increase in toxicity.