1.
Bioorg Med Chem Lett
; 17(15): 4369-73, 2007 Aug 01.
Article
in English
| MEDLINE
| ID: mdl-17601734
ABSTRACT
A series of indane acetic acid derivatives were prepared which show a spectrum of activity as insulin sensitizers and PPAR-alpha and PPAR-delta ligands. In vivo data are presented for insulin sensitizers with selectivity for PPAR-delta over PPAR-alpha.
Subject(s)
Insulin Resistance , PPAR delta/agonists , Fluorescence Resonance Energy Transfer , Structure-Activity Relationship
2.
Bioorg Med Chem Lett
; 16(2): 297-301, 2006 Jan 15.
Article
in English
| MEDLINE
| ID: mdl-16275080
ABSTRACT
A series of oxazole-substituted indanylacetic acids were prepared which show a spectrum of activity as ligands for PPAR nuclear receptor subtypes.