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SWI/SNF remains localized to chromatin in the presence of SCHLAP1.
Raab, Jesse R; Smith, Keriayn N; Spear, Camarie C; Manner, Carl J; Calabrese, J Mauro; Magnuson, Terry.
Nat Genet ; 51(1): 26-29, 2019 01.
Article in English | MEDLINE | ID: mdl-30510238

ABSTRACT

SCHLAP1 is a long noncoding RNA that is reported to function by depleting the SWI/SNF complex from the genome. We investigated the hypothesis that SCHLAP1 affects only specific compositions of SWI/SNF. Using several assays, we found that SWI/SNF is not depleted from the genome by SCHLAP1 and that SWI/SNF is associated with many coding and noncoding RNAs, suggesting that SCHLAP1 may function in a SWI/SNF-independent manner.


Subject(s)
Chromatin/genetics , Chromosomal Proteins, Non-Histone/genetics , RNA, Long Noncoding/genetics , Transcription Factors/genetics , Cell Line , Genome, Human/genetics , Humans
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